A one-pill-a-day treatment with promising results<\/strong><\/p>\nThe study, called “Beamion LUNG-1”, has included more than 120 patients distributed in various groups according to the type of mutation and previous treatments, and has shown promising results. The group that has obtained the best results has been that of patients with a specific mutation within the tyrosine kinase domain, where 71% of those who have taken the drug have shown a significant reduction of the tumour, with very few side effects and an average of one year free of disease before the tumour reappears.<\/p>\n
On the other hand, in patients who had already received an antibody directed against HER2, as well as in other less common mutations, good responses have also been observed (between 30% and 48%). In addition to its efficacy, the drug stands out for its safety since only 17% of the patients treated have suffered serious adverse effects related to the treatment, and there wasn\u2019t any case of serious inflammation of the lung caused by the treatment.<\/p>\n
For the medical oncologist specialising in lung and one of the researchers who participated in the study, Ernest Nadal, “We are facing an important advance, because this new treatment, zongertinib, has shown high efficacy for a specific subgroup of patients with lung cancer with a mutation of the <\/em>HER2 gene. Compared to other treatments that had been studied in this subgroup of patients, zongertinib has several advantages for being an oral therapy, due to good tolerance and because it does not cause lung inflammation<\/em>.”<\/p>\nThe research team that has prepared this study continues in this line of research in order to confirm these results in a phase III trial, which seeks to demonstrate whether this targeted therapy is more beneficial than chemo-immunotherapy as the first treatment in this defined population of patients. At this point, and if these results are maintained, zongertinib could become a new tool in the treatment of HER2-mutated lung cancer and, above all, for a group of patients who until now had few treatment alternatives<\/strong>.<\/p>\n <\/p>\n
<\/p>\n
The Bellvitge Biomedical Research Institute (IDIBELL) is a research center established in 2004 specialized in cancer, neuroscience, translational medicine, and regenerative medicine. It counts on a team of more than 1.500 professionals who, from 73 research groups, publish more than 1.400 scientific articles per year. IDIBELL is participated by the Bellvitge University Hospital and the Viladecans Hospital of the Catalan Institute of Health, the Catalan Institute of Oncology, the University of Barcelona, \u200b\u200band the City Council of L’Hospitalet de Llobregat.<\/em><\/p>\nIDIBELL is a member of the Campus of International Excellence of the University of Barcelona HUBc and is part of the CERCA institution of the Generalitat de Catalunya. In 2009 it became one of the first five Spanish research centers accredited as a health research institute by the Carlos III Health Institute. In addition, it is part of the “HR Excellence in Research” program of the European Union and is a member of EATRIS and REGIC. Since 2018, IDIBELL has been an Accredited Center of the AECC Scientific Foundation (FCAECC).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"Zongertinib could become a new tool in the treatment of HER-2 mutated lung cancer, specially for an specific group of patients<\/p>\n","protected":false},"author":8,"featured_media":25676,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[180,264,181],"tags":[],"class_list":["post-25665","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","category-molecular-mechanisms-and-experimental-therapy-in-oncology-program-oncobell","category-cell-death-and-metabolism"],"publishpress_future_action":{"enabled":false,"date":"2025-05-30 11:53:49","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts\/25665","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/comments?post=25665"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts\/25665\/revisions"}],"predecessor-version":[{"id":25667,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts\/25665\/revisions\/25667"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media\/25676"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media?parent=25665"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/categories?post=25665"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/tags?post=25665"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}