{"id":23541,"date":"2024-01-22T10:50:00","date_gmt":"2024-01-22T09:50:00","guid":{"rendered":"https:\/\/idibell.cat\/en\/?p=23541"},"modified":"2024-01-22T13:40:02","modified_gmt":"2024-01-22T12:40:02","slug":"the-ministry-of-science-and-innovation-awards-e4-million-for-the-phase-2b-clinical-trial-with-a-new-drug-for-ischemic-stroke","status":"publish","type":"post","link":"https:\/\/idibell.cat\/en\/2024\/01\/the-ministry-of-science-and-innovation-awards-e4-million-for-the-phase-2b-clinical-trial-with-a-new-drug-for-ischemic-stroke\/","title":{"rendered":"The Ministry of Science and Innovation awards \u20ac4 million for the Phase 2b clinical trial with a new drug for ischemic stroke"},"content":{"rendered":"<p>The consortium formed by <strong>aptaTargets<\/strong>, the <a href=\"https:\/\/idibell.cat\/en\/\">Bellvitge Biomedical Research Institute<\/a> (IDIBELL), the <a href=\"https:\/\/www.germanstrias.org\/en\/\">Germans Trias i Pujol Research Institute<\/a> (IGTP), the <a href=\"https:\/\/universityofvalladolid.uva.es\/\">University of Valladolid<\/a> and the <a href=\"https:\/\/vhir.vallhebron.com\/en\">Vall d&#8217;Hebron Research Institute<\/a> (VHIR) has received \u20ac4 million in funding from the Spanish Ministry of Science and Innovation through the <a href=\"https:\/\/www.aei.gob.es\/en\">State Research Agency<\/a> (AEI).<\/p>\n<p>&nbsp;<\/p>\n<p>The grant will support the <strong>NexTOLL project<\/strong>, which aims to launch a multicentre Phase 2b clinical trial to confirm the neuroprotective effect of <strong>ApTOLL<\/strong> in patients with <strong>acute ischemic stroke<\/strong> (AIS). The clinical trial is scheduled to start in 2024 and Pere Cardona, Principal Investigator at the <a href=\"https:\/\/idibell.cat\/es\/investigacion\/area-de-neurociencias\/programa-de-neurociencias\/enfermedades-neurologicas-y-neurogenetica\/\">Neurologic Diseases and Neurogenetics research group<\/a> at IDIBELL and Director of <a href=\"https:\/\/bellvitgehospital.cat\/en\/services\/neurology\">Neurovascular Program and Stroke Unit<\/a> at the Bellvitge University Hospital, will be among the neurologists conducting it.<\/p>\n<p>&nbsp;<\/p>\n<p>These funds come from a highly competitive call for proposals from the State Programme for the Promotion of Scientific and Technical Research and its Transfer 2022 (formerly known as <em>Retos Colaboraci\u00f3n<\/em>) which provides funding for public-private collaboration projects to catalyse innovation and business leadership in small and medium-sized enterprises (SMEs).<\/p>\n<p>&nbsp;<\/p>\n<p>Notably, the results of the research conducted with ApTOLL to date are very encouraging. ApTOLL is the first neuroprotective drug to obtain <a href=\"https:\/\/aptatargets.com\/newsroom\/aptoll-reduces-mortality-from-18-to-5-in-a-phase-1b-2a-trial-in-ischemic-stroke-patients\/\">positive results in clinical trials<\/a> with patients, which were presented at the International Stroke Conference 2023 and published in the prestigious scientific journal <a href=\"https:\/\/aptatargets.com\/newsroom\/jama-neurology-publishes-the-results-from-phase-1b-2a-clinical-trial-of-the-neuroprotective-drug-aptoll-for-ischemic-stroke\/\"><em>JAMA Neurology<\/em><\/a><em>. <\/em><\/p>\n<p>&nbsp;<\/p>\n<p>The funding received from the AEI is key to <strong>bringing ApTOLL to the market<\/strong>, which could provide an important therapeutic option for stroke patients who have a significant unmet medical need.<\/p>\n<p><em>\u00a0<\/em><\/p>\n<p><em>A Phase IIb Clinical trial to the evaluate neuroprotective effect of ApTOLL in stroke patients. <\/em><em>NexTOLL CPP2022-<\/em><em>009778.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Collaborative success in advancing stroke neuroprotection<\/p>\n","protected":false},"author":8,"featured_media":23542,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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