{"id":21866,"date":"2023-02-06T11:08:14","date_gmt":"2023-02-06T10:08:14","guid":{"rendered":"https:\/\/idibell.cat\/en\/?p=21866"},"modified":"2023-02-06T11:08:54","modified_gmt":"2023-02-06T10:08:54","slug":"new-treatment-options-are-opening-up-in-the-field-of-cutaneous-lymphomas-thanks-to-an-immunotherapy-based-drug","status":"publish","type":"post","link":"https:\/\/idibell.cat\/en\/2023\/02\/new-treatment-options-are-opening-up-in-the-field-of-cutaneous-lymphomas-thanks-to-an-immunotherapy-based-drug\/","title":{"rendered":"New treatment options are opening up in the field of cutaneous lymphomas thanks to an immunotherapy-based drug"},"content":{"rendered":"
A clinical study led by researchers of the IDIBELL hematopoietic and lymphoid tumor research group and the dermatology service of the Bellvitge University Hospital (HUB) confirms that brentuximab vedotin is effective and safe for some types of cutaneous lymphomas T cells (LCCT). This represents a significant advance for the treatment of these types of low-recurrence, albeit chronic, progressive and debilitating cancers.<\/p>\n
LCCTs are collectively known as non-Hodgkin’s lymphomas. They begin as rashes on the skin when lymphocytes, a type of white blood cell, become cancerous through a process that is not yet known. Brentuximab is a type of targeted therapy with an antibody component that attaches to the CD30 protein, which is found on the surface of tumor cells, and which then releases the drug while destroying these cells.<\/p>\n
The results -extracted from the study of 67 patients from 21 hospitals throughout the State and data from the Spanish Cutaneous Lymphoma Registry (RELCP)- have been published in the European Journal of Dermatology and Venereology<\/em>. The work has been coordinated by Dr. Cristina Muniesa, researcher at IDIBELL, HUB and Hospital de Viladecans, and has counted on the thrust of the Fundaci\u00f3n Piel Sana AEDV.<\/p>\n Until now, the actual clinical practice with brentuximab vedotin was very limited in LCCTs, due to the low prevalence of these cancers.<\/p>\n However, this study opens new paths for treatment research, providing new data on the effectiveness of this immunotherapy in the treatment of advanced forms of mycosis fungoides and CD30+ lymphoproliferative disorders, as well as for S\u00e9zary syndrome and mycosis fungoides follicular<\/p>\n The follow-up data 18 months after the start with the treatment cycles show that 67% of the patients responded to the drug and 24% had achieved total remission of the plaques and tumors they presented on the skin. According to the publication, the therapy is generally well tolerated, although neuropathy is the most frequent adverse effect, affecting 57% of patients.<\/p>\n <\/p>\nIDIBELL and Bellvitge Hospital, leaders in cutaneous lymphomas<\/h3>\n