{"id":15668,"date":"2020-12-16T12:50:52","date_gmt":"2020-12-16T11:50:52","guid":{"rendered":"https:\/\/idibell.cat\/en\/?p=15668"},"modified":"2020-12-16T12:50:52","modified_gmt":"2020-12-16T11:50:52","slug":"a-study-evaluates-the-effectiveness-of-colon-and-gynecological-surgeries-and-their-risk-reduction-in-patients-affected-by-lynch-syndrome","status":"publish","type":"post","link":"https:\/\/idibell.cat\/en\/2020\/12\/a-study-evaluates-the-effectiveness-of-colon-and-gynecological-surgeries-and-their-risk-reduction-in-patients-affected-by-lynch-syndrome\/","title":{"rendered":"A study evaluates the effectiveness of colon and gynecological surgeries and their risk reduction in patients affected by Lynch syndrome"},"content":{"rendered":"

A study<\/a> carried out by the Hereditary Cancer Group of the Bellvitge Biomedical Research Institute (IDIBELL<\/a>) – Catalan Institute of Oncology (ICO<\/a>), with the collaboration of the General and Digestive Surgery, Gynecology and Pathology Services of the Bellvitge University Hospital and Germans Trias i Pujol University Hospital, has analyzed the impact of risk-reducing surgeries in the incidence and mortality of Lynch Syndrome<\/strong>\u2019s colon and gynecological cancer.<\/p>\n

Colorectal cancer<\/strong> and endometrial cancer<\/strong> represent a significant risk to life in individuals with Lynch syndrome, with an incidence at 75 years of up to 40-60%. Furthermore, monitoring of these tumors, especially gynecological tumors, has not been shown to be effective. Thus, risk-reducing surgeries may represent an interesting option for people affected by this syndrome, leading to a reduction in the incidence of cancer and its mortality.<\/p>\n

\u00a0<\/strong><\/p>\n

How has this study been carried out?<\/h3>\n

 <\/p>\n

This study analyzed the cumulative incidence of cancer and mortality from colorectal, endometrial and ovarian cancer in 976 patients<\/strong> with Lynch Syndrome. These patients could be in cancer follow-up programs or have undergone risk-reducing surgery, both colon after the first diagnosis of colorectal cancer, and gynecological in women without a previous diagnosis of endometrial or ovarian cancer.<\/p>\n

After a mean follow-up of 10.2 years<\/strong>, a statistically significant decrease in the cumulative incidence of metachronous colorectal cancer has been demonstrated after performing extensive colon surgery as a treatment for the first colorectal cancer (12.5% \u200b\u200bof extensive surgery versus 44.7% of segmental surgery, p=0.04). In addition, a statistically significant decrease in the cumulative incidence of endometrial cancer has also been shown (11.2% of risk-reducing gynecological surgery versus 46.3% of follow-up, p=0.001); ovarian cancer (0.0% risk-reducing gynecological surgery vs. 12.7% follow-up, p=N\/A) and all-cause mortality (0.0% risk-reducing gynecological surgery vs. 52.7% of follow-up, p=0.001) after performing risk-reducing gynecological surgery.<\/p>\n

According to the researcher and first author of the article, N\u00faria Due\u00f1as<\/strong>, “these data are important because it is the first study published where a reduction in mortality is shown, for any cause and specific cancer, in women affected by Lynch syndrome with risk-reducing gynecological surgery<\/em> “.<\/p>\n","protected":false},"excerpt":{"rendered":"

The results show that this type of surgery can represent a good option for people affected by this syndrome since it supposes a reduction in the incidence of cancer and its mortality.<\/p>\n","protected":false},"author":8,"featured_media":15669,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[180,238,264],"tags":[],"class_list":["post-15668","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","category-hereditary-cancer-molecular-mechanisms-and-experimental-therapy-in-oncology-program-oncobell","category-molecular-mechanisms-and-experimental-therapy-in-oncology-program-oncobell"],"publishpress_future_action":{"enabled":false,"date":"2024-12-25 20:52:51","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts\/15668","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/comments?post=15668"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts\/15668\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media\/15669"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media?parent=15668"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/categories?post=15668"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/tags?post=15668"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}