ICO<\/a>), the Bellvitge Biomedical Research Institute (IDIBELL), CIBERESP, and the University of Barcelona, \u200b\u200band his team. The research group led by Dr. Steven Gruber, from the ‘City of Hope National Medical Center’ in Los Angeles, USA, Dr. Harlan Robins, CEO of the Adaptive Biotechnologies company, spin-off of the Cold Hutch Cancer Research Center, Seattle, USA, and Prof. Gad Rennert, Carmel Medical Center and Technion, Haifa, Israel.<\/p>\n <\/p>\n
How has this study been carried out?<\/h3>\n
<\/p>\n
Using this new TCR immuno-sequencing technique, a total of 640 colorectal cancer tumors<\/strong> have been sequenced from four different studies, three from patients from ICO Hospitalet and one from Israel. Thus, unlike the other methods, by sequencing the TCR regions (receptor for lymphocytes that recognize tumor antigens), both, the abundance of the T cell that infiltrates to the tumor and the clonality index, were obtained.<\/p>\nThe results obtained have shown that the combination of both variables, quantity and clonality, is associated with the prognosis. The samples with the highest amount of TCR and diversity of clones are those that show a better prognosis of the disease. According to the head of the Oncology Data Analysis Program (PADO) of the ICO-IDIBELL, V\u00edctor Moreno, “the results of this study show that higher levels of TCR, and a greater diversity of TCR receptor, is associated with a better prognosis in this specific group of patients where there are still no clear markers of recurrence<\/em>“.<\/p>\n <\/p>\n","protected":false},"excerpt":{"rendered":"
This study has used a new technique called ‘T-cell receptor (TCR) immuno-sequencing’, which allows us to obtain both the number of T lymphocytes that infiltrate the tumor and their clonality index.<\/p>\n","protected":false},"author":8,"featured_media":14759,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[180,183,264],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-09 16:11:20","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts\/14758"}],"collection":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/comments?post=14758"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts\/14758\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media\/14759"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media?parent=14758"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/categories?post=14758"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/tags?post=14758"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}