Journal for Immunotherapy of Cancer<\/em><\/a>, analyzes 374 metastatic samples from the four secondary organs most likely to be invaded by disseminated tumour cells (brain, bones, liver, and lung), and belonging to cancers placed in different primary locations.<\/p>\n“The bioinformatic analyses carried out have refuted the ‘seed and soil’ hypothesis and revealed that metastatic tumours located in the lungs, regardless of the cancer primary location<\/strong>, share characteristics of inflammation and immune infiltration. Therefore, they could respond to the same treatment<\/strong> with immunotherapy\u201d, says Sandra Garc\u00eda-Mulero, the first author of the study.<\/p>\nFurthermore, significant differences<\/strong> were found between the immune profiles of metastasis in different organs. In the liver, metastasis tends to be poorly immunogenic, which means that hardly activates the immune system. In contrast, the results showed that metastasis in the lungs<\/strong> tend to be highly immunogenic and induces an inflammatory reaction. One of the hypotheses that would explain the lung susceptibility to metastasis would be that the lungs themselves could activate immunosuppressive mechanisms to avoid a massive immune reaction, and tumours would take advantage of this situation to facilitate metastasis.<\/p>\nAbout therapy for these highly inflammatory metastatic tumours, treatment with blockers could be considered, which would allow the immune response of the lungs, favouring the destruction of cancer cells.<\/p>\n","protected":false},"excerpt":{"rendered":"
Lung metastatic tumours have common immune properties, regardless of the origin of the primary tumour.
\nThese results suggest new approximations and contemplate the development of new immunotherapy treatments.<\/p>\n","protected":false},"author":8,"featured_media":10755,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[180,264,213],"tags":[],"class_list":["post-10754","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","category-molecular-mechanisms-and-experimental-therapy-in-oncology-program-oncobell","category-transformation-and-metastasis"],"publishpress_future_action":{"enabled":false,"date":"2024-11-12 04:05:51","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts\/10754"}],"collection":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/comments?post=10754"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts\/10754\/revisions"}],"predecessor-version":[{"id":18878,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts\/10754\/revisions\/18878"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media\/10755"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media?parent=10754"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/categories?post=10754"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/tags?post=10754"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}