{"id":2965,"date":"2019-10-09T21:14:13","date_gmt":"2019-10-09T19:14:13","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2965"},"modified":"2024-06-10T15:14:53","modified_gmt":"2024-06-10T13:14:53","slug":"nephrology-and-renal-transplantation","status":"publish","type":"page","link":"https:\/\/idibell.cat\/en\/research\/translational-medicine-area\/infectious-disease-and-transplantation-program\/nephrology-and-renal-transplantation\/","title":{"rendered":"Nephrology and renal transplantation"},"content":{"rendered":"\n
The Nephrology research group interest spans a broad area, ranging from immunology, renal replacement therapy, transplantation, chronic kidney disease including diabetic nephropathy, and regenerative medicine. Our research is mainly translational, collaborative and aimed to improve the care and health of patients with kidney diseases. Our ultimate goal is innovation in disease monitoring and therapy, gathering basic science with our clinical expertise, to move towards personalized medicine in Nephrology.<\/p>\n
Immunological risk stratification and new immune monitoring tools in kidney transplantation.<\/p>\n
Development of new therapies in collaboration with the pharmaceutical industry for kidney transplantation and other nephrology areas.<\/p>\n
Pharmacokinetics and pharmacodymanics to improve management of immunosuppression<\/p>\n
Renal progenitor cells as mediators of kidney repair after damage<\/p>\n
Personalized medicine in kidney transplantation<\/p>\n
Mechanisms of damage in glomerulonephritis and other autoimmune kidney diseases<\/p>\n
Mechanisms of vascular damage in chronic kidney disease<\/p>\n\t\t\t\t\tSelected Publications<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t Proyectos financiados por el Instituto de Salud Carlos III (ISCIII) y cofinanciados por el Fondo Europeo de Desarrollo Regional (FEDER):<\/i><\/p>\n \u00a0<\/p>\n Estudio prospectivo, aleatorizado para la predicci\u00f3n de la infecci\u00f3n por el citomegalovirus (hCMV) seg\u00fan la respuesta immunol\u00f3gica celular basal CMV-espec\u00edfica en trasplantados renales<\/b><\/p>\n ICI14\/00242. 01\/2015-12\/2018. 120.500 \u20ac. IP: Oriol Bestard Matamoros.<\/p>\n Evaluar la validez de la monitorizaci\u00f3n de la respuesta inmune adaptativa celular(T) (RIAC) hCMVespec\u00edfica antes del trasplante renal mediante la t\u00e9cnica ELISPOT-IFN-\u03b3, para diferenciar aquellos pacientes con una predisposici\u00f3n inmunol\u00f3gica basal a desarrollar la infecci\u00f3n por el hCMV despu\u00e9s del trasplante para finalmente establecer estrategias terap\u00e9uticas antivirales individualizadas.<\/p>\n \u00a0<\/p>\n An\u00e1lisis integral de los mecanismos efectores inmunol\u00f3gicos fundamentales y su expresi\u00f3n a nivel molecular en el desarrollo de la Disfunci\u00f3n Cr\u00f3nica del Trasplante Renal<\/b><\/p>\n PI13\/01263. 01\/2014-12\/2016. 96.000 \u20ac. IP: Oriol Bestard Matamoros.<\/p>\n Describir la cin\u00e9tica de aparici\u00f3n de los principales mecanismos efectores de la respuesta inmunol\u00f3gica donante-espec\u00edfica (d-s) (celular y humoral) mediante tests funcionales sensibles y su traducci\u00f3n biol\u00f3gica a nivel molecular en la aparici\u00f3n de lesiones histol\u00f3gicas espec\u00edficas halladas en biopsias renales iterativas despu\u00e9s del trasplante renal.<\/p>\n \u00a0<\/p>\n C\u00e9lulas parietales de la c\u00e1psula de Bowman (PECs), regeneraci\u00f3n y da\u00f1o en el trasplante renal. Identificaci\u00f3n de dianas terap\u00e9uticas y terapia celular con PECs en isquemia-reperfusi\u00f3n<\/b><\/p>\n PI15\/00638. 01\/2016-12\/2018. 121.500 \u20ac. IP: Jose Maria Cruzado Garrit.<\/p>\n Determinar los perfiles de expresi\u00f3n y regulaci\u00f3n g\u00e9nica en c\u00e9lulas progenitoras PEC obtenidas de receptores de trasplante renal y correlacionarlos con la severidad de la lesi\u00f3n deisquemiareperfusi\u00f3n (I\/R). Correlacionar estos patrones en PEC con datos de funci\u00f3n renal y de respuesta efectora aloinmune, elaborar un listado de genes espec\u00edficos con rol relevante en el proceso reparador o fibr\u00f3tico, caracterizar el papel funcional in vitro de genes espec\u00edficos en regeneraci\u00f3n\/fibrosis empleando l\u00edneas celulares PEC transfectadas gen\u00e9ticamente y analizar in vivo el efecto de la terapia celular basada en PEC en un modelo murino de I\/R.<\/p>\n \u00a0<\/p>\n Optimizaci\u00f3n de la dosis de tacrolimus mediante predicci\u00f3n bayesiana en pacientes trasplantados renales incluyendo las variables farmacogen\u00f3micas<\/b><\/p>\n PI15\/00871. 01\/2016-12\/2018. 79.500 \u20ac. IP: N\u00faria Lloberas Blanch.<\/p>\n La farmacocin\u00e9tica de tacrolimus (Tac) se caracteriza por una elevada variabilidad inter e intra-individual con estrecho margen terap\u00e9utico. Actualmente, el punto limitante de la monitorizaci\u00f3n farmacol\u00f3gica de Tac es la incapacidad de individualizar las dosis durante los primeros d\u00edas post-trasplante. El objetivo del estudio es optimizar la dosificaci\u00f3n de Tac para incrementar el porcentaje de pacientes con concentraciones pre-dosis (Co) terap\u00e9utica (6-10 ng\/mL) desde el inicio del tratamiento en el post-trasplante renal inmediato.<\/p>\n <\/p>\n\t\t\t\t\n Nephrology and renal transplantation Summary The Nephrology research group interest spans a broad area, ranging from immunology, renal replacement therapy, transplantation, chronic kidney disease including diabetic nephropathy, and regenerative medicine. Our research is mainly translational, collaborative and aimed to improve the care and health of patients with kidney diseases. Our ultimate goal is innovation in […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":581,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-2965","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2025-01-03 04:03:41","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/2965","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/comments?post=2965"}],"version-history":[{"count":11,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/2965\/revisions"}],"predecessor-version":[{"id":24259,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/2965\/revisions\/24259"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/581"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media?parent=2965"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}\n
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\n\t\tCruzado Garrit, Jose Maria\n\t<\/h4>\n
\n\t\t\n\t\tjcruzado@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tPrincipal investigators\n\t<\/h2>\n\t\t\t\t\n
\n\t\tCruzado Garrit, Jose Maria\n\t<\/h4>\n
\n\t\t\n\t\tjcruzado@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
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\n\t\tTeam\n\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\tGroup leaders\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPrincipal investigators\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tClinical researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPostdoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPredoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tScientific support\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tManagement support\t\t\t\t<\/a>\n\t\t\t\t\t\tGroup leaders\n\t\t\t\t\t\t\t\t\t\t\t
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\n\t\tNoticias relacionadas\n\t<\/h2>\n\t\t\n\t\t\t\t<\/a>\n\t\t\tDr. N\u00faria Lloberas receives the award for best transplant research from the Royal Academy of Medicine<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t16\/05\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tNew step towards the deployment of personalized and precision medicine in kidney transplantation<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t03\/05\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIDIBELL and Bellvitge Hospital take the first step towards personalized medicine in kidney transplantation<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t18\/12\/2023\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tScientists discover a micro-RNA that can promote the development of atherosclerosis in patients with coronary disease<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t09\/02\/2022\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tThe impact of obesity is becoming increasingly important in kidney transplantation<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t08\/07\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tFive IDIBELL’s projects receive funding from La Marat\u00f3 2020 dedicated to COVID-19<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t12\/06\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLa Marat\u00f3 will finance with 1.5 million euros 10 IDIBELL projects in rare diseases<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t30\/11\/2020\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tThe fund against Covid-19 promoted by the ISCIII will finance three IDIBELL projects<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t22\/05\/2020\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIDIBELL holds the Kickoff Meeting AES 2019 Health Research Projects funded by the ISCIII<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t03\/03\/2020\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tBellvitge Hospital and IDIBELL validates a new test to predict opportunistic virus infection risk in kidney transplant patients<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t20\/02\/2020\t\t\t\t\t\t\t\n\t\t\n\n","protected":false},"excerpt":{"rendered":"