{"id":2885,"date":"2019-10-09T00:02:02","date_gmt":"2019-10-08T22:02:02","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2885"},"modified":"2025-01-09T08:52:23","modified_gmt":"2025-01-09T07:52:23","slug":"pharmacotherapy-pharmacogenetics-and-pharmaceutical-technology","status":"publish","type":"page","link":"https:\/\/idibell.cat\/en\/research\/translational-medicine-area\/digestive-system-diagnostics-pharmacogenetics-care-support-and-clinical-prevention-program-2\/pharmacotherapy-pharmacogenetics-and-pharmaceutical-technology\/","title":{"rendered":"Pharmacotherapy, Pharmacogenetics and Pharmaceutical Technology"},"content":{"rendered":"\n<h1>\n\t\tPharmacotherapy, pharmacogenetics and pharmaceutical technology\n\t<\/h1>\n<h3>\n\t\tSummary\n\t<\/h3>\n\t<p>Research projects carried out by the group include pharmacokinetic-pharmacodynamic modelling and dose personalisation, the identification of gene polymorphisms as modulators of response and toxicity of the drugs, evaluation of the possible hepatoprotective and immunomodulatory effects of lipid emulsions rich in omega-3 in total parenteral nutrition, the application of nanotechnologies to new drug-administration systems and the research and development of new drug products for pediatric and orphan diseases.<\/p>\n<h2>520<\/h2>\n<h2>Publications<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/04\/513_llop.jpg\" alt=\"513_llop\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"513_llop\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">Strategic lines<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<p>Populational pharmacokinetic-pharmacodynamic modelling and dose individualization of biologics, antimicrobials and antifungals, and chemotherapeutic drugs: identify predictive factors of exposure variability and exposure-response relationship, predict exposure and response for different dose regimens and redefine dosing strategies to increase the probability of target attainment.<\/p>\n<p>Parenteral nutrition: the influence of omega-3 fatty acid supplements on the inflammatory response in complex high-surgical-risk patients, the protective role of omega-3 fatty acids in total parenteral nutrition-associated liver complications and polymorphisms associated with plasma phytosterols depuration.<\/p>\nPharmacogenetics: the effect of various genetic polymorphisms on the efficacy and toxicity of treatment with several drugs such as statins, thiopurines, abacavir, tacrolimus, among others.<br \/>\nPharmaceutical technology: application of nanotechnologies to new drug-administration systems, development of DNA and RNA nanoparticles as potential new agents of drug transfer and development new drugs products for orphan and pediatric diseases.\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Selected Publications<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Talaveron,JLM;Grande,A;Badosa,EL;Minguet,JB;Marti,JC;Canton,EP;Tahull,MBB, <strong>Inflammatory processes involved in the alteration of liver function biomarkers in adult hospitalized patients treated with parenteral nutrition<\/strong>, Front. Nutr., 2023;101034481-1034481, doi:10.3389\/fnut.2023.1034481<\/li>\n<li>Rouaz Hajoui,K;Garc\u00eda Montoya,E;L\u00f3pez Urbano,A;Romero Obon,M;Chiclana Rodr\u00edguez,B;Fraschi Nieto,A;Nardi Ricart,A et al, <strong>Optimisation of the Manufacturing Process of Organic-Solvent-Free Omeprazole Enteric Pellets for the Paediatric Population: Full Factorial Design<\/strong>, Pharmaceutics, 2023;15(11):doi:10.3390\/pharmaceutics15112587<\/li>\n<li>Ronda,M;Padulles,A;Grau,I;Tubau,F;Satorra,P;Shaw,E;Vigues,F et al, <strong>Impact of a prospective audit and feedback antimicrobial stewardship programme on carbapenem consumption: a quasi-experimental study (IPANEMA study)<\/strong>, J. Antimicrob. Chemother., 2023;78(7):1705-1710, doi:10.1093\/jac\/dkad160<\/li>\n<li>Martinez Casanova,J;Esteve Pitarch,E;Colom Codina,H;Gumucio Sanguino,VD;Cobo Sacristan,S;Shaw,E;Maisterra Santos,K et al, <strong>Predictive Factors of Piperacillin Exposure and the Impact on Target Attainment after Continuous Infusion Administration to Critically Ill Patients<\/strong>, Antibiotics-Basel, 2023;12(3):doi:10.3390\/antibiotics12030531<\/li>\n<li>Gonzalez,CGR;de Vega,EC;Martinez,SD;Minero,MV;Urbon,JMG;Manzorro,AG;Martinez,E et al, <strong>A critical view on the current use of daptomycin in Spain: The daptomise study<\/strong>, J Infect Public Health, 2023;16(7):1115-1122, doi:10.1016\/j.jiph.2023.05.008<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Selected Projects<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>19INT001. <strong>Antibiotic plasma level concentrations during continuous renal replacement therapy with a high absorptive membrane (oXiris\u00ae)<\/strong>. BAXTER HEALTHCARE CORPORATION. Budget: 11.065,26\u20ac. 2019-2023. PI: Colom Codina, Helena.<\/li>\n<li>PUB23009. <strong>HUB &#8211; RECCaracterizaci\u00f3n de las dislipemias polig\u00e9nicas: de la teor\u00eda a la pr\u00e1ctica<\/strong>. Hospital Universitario de Bellvitge. Budget: 20.000\u20ac. 2023-2026. PI: Padr\u00f3 i Miquel, Ariadna.<\/li>\n<li>21MAR009. <strong>Catalan interhospital network of genetic variants to improve genetic diagnosis in rare diaseases<\/strong>. Fundaci\u00f3 La Marat\u00f3 de TV3. Budget: 26.625\u20ac. 2021-2024. PI: Padr\u00f3 i Miquel, Ariadna.<\/li>\n<li>19PNJ030.<strong> CONTROLES DE CALIDAD DEL ESTUDIO &#8220;ESTUDIO DE EVALUACI\u00d3N-VALIDACI\u00d3N DE INMUNOSUPRESORES (EVEROLIMUS Y SIROLIMUS)<\/strong>. 2019- . PI: Al\u00eda Ramos, Pedro.<\/li>\n<li>2023-593-1. <strong>ESTUDIO OBSERVACIONAL PARA EVALUAR LA ADHERENCIA A TREMFYA\u00ae (GUSELKUMAB) EN LA PR\u00c1CTICA CL\u00cdNICA EN PACIENTES CON PSORIASIS MODERADA A GRAVE<\/strong>. Janssen-Cilag, S.A. Budget: 10.800\u20ac. 2023- . PI: Padull\u00e9s Zamora, N\u00faria.<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\">More Information<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-3\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<p>Our IDIBELL research group works in close collaboration with researchers at the School of Pharmacy of the University of Barcelona (Service of Drug Development [SDM] and the Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry. The SDM within the School of Pharmacy collaborates with pharmaceutical and other related industries in the field of Pharmaceutical Technology. Other non-competitive contracts or agreements with companies managed through The Bosch i Gimpera Foundation have been performed by the Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry in the field of Pharmacokinetics.<\/p>\nPatents: Patente de invenci\u00f3n (Europea). T\u00edtulo de la invenci\u00f3n: Descongestant and bilastine drugs delivery system. Inventores: J.M\u00aa Su\u00f1\u00e9 Negre, M Roig Carreras, F Gual Pujol, P Marcianes, I Ortega Azpitarte, G Hern\u00e1ndez Herrrero. Solicitante: FAES FARMA, SA.<br \/>\nN\u00famero de registro: EP 20382701.9 (Prioridad XX.XX.2020). Fecha de presentaci\u00f3n: 30 de julio de 2020. Lugar de presentaci\u00f3n: Canadian Intellectual Property Office.\n<p>Doctoral theses directed by a member of the group and read or diposited in 2020: 6 PhD students successfully defended their theses. Active doctoral theses directed by a member of the group: 10 PhD students.<\/p>\n<p>Several members of our group are involved in teaching activities for degrees, Master degrees and specialized courses since 2015. In a proposal of continuous training, members of our team yearly attend to international and national workshops organized by scientific organisms.<\/p>\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2019\/10\/padulles-zamora-nuria-150x150.jpg\" alt=\"Padull\u00e9s Zamora, N\u00faria\" itemprop=\"image\" title=\"padulles-zamora-nuria\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tPadull\u00e9s Zamora, N\u00faria\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:npadulles@idibell.cat\" title=\"npadulles@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tnpadulles@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tPrincipal investigators\n\t<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2019\/10\/padulles-zamora-nuria-150x150.jpg\" alt=\"Padull\u00e9s Zamora, N\u00faria\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"padulles-zamora-nuria\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tPadull\u00e9s Zamora, N\u00faria\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:npadulles@idibell.cat\" title=\"npadulles@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tnpadulles@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2019\/09\/avatar-150x150.jpeg\" alt=\"avatar\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"avatar\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tLeiva Badosa, Elisabet\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:eleiva@idibell.cat\" title=\"eleiva@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\teleiva@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2019\/10\/llop-talaveron-josep-150x150.jpg\" alt=\"llop-talaveron-josep\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"llop-talaveron-josep\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tLlop Talaveron, Josep\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:jllop@idibell.cat\" title=\"jllop@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tjllop@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2023\/12\/Helena-Colom-Codina-150x150.jpg\" alt=\"Helena-Colom-Codina\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Helena-Colom-Codina\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tColom Codina, Helena\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:hcolom@idibell.cat\" title=\"hcolom@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\thcolom@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2019\/09\/avatar-150x150.jpeg\" alt=\"avatar\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"avatar\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tAlia Ramos, Pedro\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:palia@idibell.cat\" title=\"palia@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tpalia@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\tRELATED LINKS\n\t<\/h4>\n<h4>\n\t\t<a href=\"http:\/\/www.ub.edu\/sdm\/in_index.htm\" title=\"Service of Development of Medicines (SDM)\" target=\"_blank\" rel=\"noopener\">\n\t\tService of Development of Medicines (SDM)\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/webgrec.ub.edu\/cgi-bin\/3DADREC\/crfitgrup.cgi?PAR=FARMACOC\" title=\"Grup de Recerca Farmacocin\u00e8tica poblacional\" target=\"_blank\" rel=\"noopener\">\n\t\tGrup de Recerca Farmacocin\u00e8tica poblacional\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/ElisabetLeiva\" title=\"@ElisabetLeiva\" target=\"_blank\" rel=\"noopener\">\n\t\t@ElisabetLeiva\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tTeam\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tGroup leaders\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPrincipal investigators\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tClinical researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPredoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-4\" data-index=\"4\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-4\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tScientific support\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-5\" data-index=\"5\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-5\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tManagement support\t\t\t\t<\/a>\n\t\t\t\t\t\tGroup leaders\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Padull\u00e9s Zamora, N\u00faria<\/li>\n<\/ul>\n\t\t\t\t\t\tPrincipal investigators\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Llop Talaveron, Josep<\/li>\n<li>Colom Codina, Helena<\/li>\n<li>Alia Ramos, Pedro<\/li>\n<li>Leiva Badosa, Elisabet<\/li>\n<\/ul>\n\t\t\t\t\t\tClinical researchers\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Juvany Roig, Roser<\/li>\n<li>Padulles Zamora, Ariadna<\/li>\n<li>Badia Tahull, Maria<\/li>\n<li>Su\u00f1e Negre, Josep Maria<\/li>\n<li>Mi\u00f1arro Carmona, Montserrat<\/li>\n<li>Padro Miquel, Ariadna<\/li>\n<li>Perez Lozano, Pilar<\/li>\n<li>Garcia Montoya, Encarna<\/li>\n<li>Llecha Cano, N\u00faria<\/li>\n<li>Santacana Juncosa, Eug\u00e8nia<\/li>\n<li>Su\u00f1\u00e9 Pou, Marc<\/li>\n<li>Rouaz El Hajoui, Khadija<\/li>\n<\/ul>\n\t\t\t\t\t\tPredoctoral researchers\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Cobo Sacristan, Sara<\/li>\n<li>Colls Gonzalez, Montserrat<\/li>\n<li>Su\u00e1rez-Lled\u00f3 Grande, Ana<\/li>\n<li>Garrido Sanchez, Leticia<\/li>\n<li>Martinez Casanovas, Javier<\/li>\n<\/ul>\n\t\t\t\t\t\tScientific support\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Quiles Petidier, Sara<\/li>\n<\/ul>\n\t\t\t\t\t\tManagement support\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Ferrer Artola, Ana Maria<\/li>\n<li>Canals Vilaseca, Laura<\/li>\n<\/ul>\n<h2>\n\t\tRelated news\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/15526\" content=\"La Marat\u00f3 will finance with 1.5 million euros 10 IDIBELL projects in rare diseases\" \/><meta itemprop=\"datePublished\" content=\"2020-11-30\" \/><meta itemprop=\"dateModified\" content=\"2020-11-30\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/11\/imatge-marato.png\" \/><meta itemprop=\"width\" content=\"680\" \/><meta itemprop=\"height\" content=\"384\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2020\/11\/la-marato-will-finance-with-1-5-million-euros-10-idibell-projects-in-rare-diseases\/\" title=\"La Marat\u00f3 will finance with 1.5 million euros 10 IDIBELL projects in rare diseases\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2020\/11\/la-marato-will-finance-with-1-5-million-euros-10-idibell-projects-in-rare-diseases\/\" title=\"La Marat\u00f3 will finance with 1.5 million euros 10 IDIBELL projects in rare diseases\">La Marat\u00f3 will finance with 1.5 million euros 10 IDIBELL projects in rare diseases<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t30\/11\/2020\t\t\t\t\t\t\t\n\t\t<!-- .pp-content-posts -->\n\n","protected":false},"excerpt":{"rendered":"<p>Pharmacotherapy, pharmacogenetics and pharmaceutical technology Summary Research projects carried out by the group include pharmacokinetic-pharmacodynamic modelling and dose personalisation, the identification of gene polymorphisms as modulators of response and toxicity of the drugs, evaluation of the possible hepatoprotective and immunomodulatory effects of lipid emulsions rich in omega-3 in total parenteral nutrition, the application of nanotechnologies [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":579,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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