{"id":2885,"date":"2019-10-09T00:02:02","date_gmt":"2019-10-08T22:02:02","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2885"},"modified":"2023-12-04T09:58:09","modified_gmt":"2023-12-04T08:58:09","slug":"pharmacotherapy-pharmacogenetics-and-pharmaceutical-technology","status":"publish","type":"page","link":"https:\/\/idibell.cat\/en\/research\/translational-medicine-area\/digestive-system-diagnostics-pharmacogenetics-care-support-and-clinical-prevention-program-2\/pharmacotherapy-pharmacogenetics-and-pharmaceutical-technology\/","title":{"rendered":"Pharmacotherapy, Pharmacogenetics and Pharmaceutical Technology"},"content":{"rendered":"\n

\n\t\tPharmacotherapy, Pharmacogenetics and Pharmaceutical Technology\n\t<\/h1>\n

\n\t\tSummary\n\t<\/h3>\n\t

Research projects carried out by the group include pharmacokinetic-pharmacodynamic modelling and dose personalisation, the identification of gene polymorphisms as modulators of response and toxicity of the drugs, evaluation of the possible hepatoprotective and immunomodulatory effects of lipid emulsions rich in omega-3 in total parenteral nutrition, the application of nanotechnologies to new drug-administration systems and the research and development of new drug products for pediatric and orphan diseases.<\/p>\n

520<\/h2>\n

Publications<\/h2>\n\t\t\t\t\"513_llop\"\n\t\t\t\t\tStrategic lines<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t

Populational pharmacokinetic-pharmacodynamic modelling and dose individualization of biologics, antimicrobials and antifungals, and chemotherapeutic drugs: identify predictive factors of exposure variability and exposure-response relationship, predict exposure and response for different dose regimens and redefine dosing strategies to increase the probability of target attainment.<\/p>\n

Parenteral nutrition: the influence of omega-3 fatty acid supplements on the inflammatory response in complex high-surgical-risk patients, the protective role of omega-3 fatty acids in total parenteral nutrition-associated liver complications and polymorphisms associated with plasma phytosterols depuration.<\/p>\nPharmacogenetics: the effect of various genetic polymorphisms on the efficacy and toxicity of treatment with several drugs such as statins, thiopurines, abacavir, tacrolimus, among others.
\nPharmaceutical technology: application of nanotechnologies to new drug-administration systems, development of DNA and RNA nanoparticles as potential new agents of drug transfer and development new drugs products for orphan and pediatric diseases.\n\t\t\t\t\t
Selected Publications<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t

Pa\u00f1o Pardo JR, Moreno Rodilla E, Cobo Sacristan S, Cubero Salda\u00f1a JL, Peria\u00f1ez P\u00e1rraga L, Del Pozo Le\u00f3n JL, Retamar Genti P, Rodr\u00edguez Oviedo A, Torres Ja\u00e9n MJ, Vidal Cortes P, Col\u00e1s Sanz C. Management of Patients with Suspected or Confirmed Antibiotic Allergy<\/strong>. Executive Summary of Guidance from the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), the Spanish Society of Allergy and Clinical Immunology (SEAIC), the Spanish Society of Hospital Pharmacy (SEFH) and the Spanish Society of Intensive Medicine and Coronary Care Units (SEMICYUC)<\/strong>. J Investig Allergol Clin Immunol. 2022;33(2):doi:10.18176\/jiaci.0859.<\/p>\n

Amor\u00f3s Galicia L, Nardi Ricart A, Verdugo Gonz\u00e1lez C, Arroyo Garc\u00eda CM, Garc\u00eda Montoya E, P\u00e9rez Lozano P, Su\u00f1\u00e9 Negre JM, Su\u00f1\u00e9 Pou M. Development of a Standardized Method for Measuring Bioadhesion and Mucoadhesion That Is Applicable to Various Pharmaceutical Dosage Forms.<\/strong> Pharmaceutics. 2022;14(10):doi:10.3390\/pharmaceutics14101995.<\/p>\n

Ronda M, P\u00e9rez Recio S, Gonz\u00e1lez Laguna M, Tubau Quintano MF, Llop Talaveron J, Soldevila Boixader L, Carratal\u00e0 J, Cuervo G, Padull\u00e9s A. Ceftolozane\/tazobactam for difficult-to-treat Gram-negative infections: A real-world tertiary hospital experience<\/strong>. J Clin Pharm Ther. 2022;47(7):932-939. doi:10.1111\/jcpt.13623.<\/p>\n

Romero Pinel L, Bau L, Matas E, Le\u00f3n I, Juvany R, J\u00f3dar R, Mart\u00ednez Y\u00e9lamos A, Mart\u00ednez Y\u00e9lamos S. Cost associated with a relapse-free patient in multiple sclerosis: A real-world health indicator<\/strong>. PLoS One. 2022;17(4):267504-267504. doi:10.1371\/journal.pone.0267504.<\/p>\n

Llop Talaveron J, Leiva Badosa E, Alia Ramos P, Rigo Bonnin R, Virgili Casas N, Farran Teixidor L, Mir\u00f3 Mart\u00edn M, Garrido Sanchez L, Su\u00e1rez Lled\u00f3 A, Bad\u00eda Tahull MB. Genetic factors associated with alterations in liver function test results in adult hospitalized patients treated with parenteral nutrition: A substudy of a clinical trial<\/strong>. Nutrition. 2022;93111507-111507. doi:10.1016\/j.nut.2021.111507.<\/p>\n\t\t\t\t\tSelected Projects<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t

21MAR009. Catalan interhospital network of genetic variants to improve genetic diagnosis in rare diaseases. (202040-32)<\/strong>\u00a0. FUNDACI\u00d3 LA MARAT\u00d3 DE TV3. Budget: 26.625,00. 2021-2024. PI: PADRO MIQUEL, ARIADNA.<\/p>\n

FIS21079. Aplicaci\u00f3n de los modelos de cin\u00e9tica poblacional de tacrolimus en distintas poblaciones de trasplante. Papel de los polimorfismos del CYP3A en el trasplante de renal y trasplante hep\u00e1tico (adulto y pedi\u00e1trico)<\/strong>. INSTITUTO DE SALUD CARLOS III (ISCIII). Budget: 200206,6. 2022-2024. PI: COLOM CODINA, HELENA i LLOBERAS BLANC, NURIA.<\/p>\n

19INT001. Antibiotic plasma level concentrations during continuous renal replacement therapy with a high absorptive membrane (oXiris\u00ae)<\/strong>. BAXTER HEALTHCARE CORPORATION. Budget: 11.065,26. 2019-2023. PI: COLOM CODINA, HELENA.<\/p>\n

19FIS011. Mecanismos post-transcripcionales reguladores de la respuesta inflamatoria en aterosclerosis y Enfermedad Renal Cr\u00f3nica: Tr\u00e1fico de macr\u00f3fagos, polarizaci\u00f3n, formaci\u00f3n de c\u00e9lulas espumosa (PI18\/01108)<\/strong>\u00a0. INSTITUTO DE SALUD CARLOS III (ISCIII). Budget: 220.220,00. 2019-2022. PI: SU\u00d1E NEGRE, JOSEP MARIA.<\/p>\n

FAR-NP-2017-01 AC012\/17. ENSAYO CL\u00cdNICO PILOTO, RANDOMIZADO, DOBLE CIEGO, PARA ESTUDIAR EL EFECTO DE LA SUPLEMENTACI\u00d3N PARENTERAL CON EMULSI\u00d3N DE ACEITE DE PESCADO EN EL SOPORTE NUTRICIONAL EN PACIENTES ESOFAGECTOMIZADOS<\/strong>. BADIA TAHULL, MARIA BELLA. Budget: 0. 2018-2022. PI: BADIA TAHULL, MARIA BELLA.<\/p>\n\t\t\t\t\tMore Information<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t

Our IDIBELL research group works in close collaboration with researchers at the School of Pharmacy of the University of Barcelona (Service of Drug Development [SDM] and the Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry. The SDM within the School of Pharmacy collaborates with pharmaceutical and other related industries in the field of Pharmaceutical Technology. Other non-competitive contracts or agreements with companies managed through The Bosch i Gimpera Foundation have been performed by the Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry in the field of Pharmacokinetics.<\/p>\nPatents: Patente de invenci\u00f3n (Europea). T\u00edtulo de la invenci\u00f3n: Descongestant and bilastine drugs delivery system. Inventores: J.M\u00aa Su\u00f1\u00e9 Negre, M Roig Carreras, F Gual Pujol, P Marcianes, I Ortega Azpitarte, G Hern\u00e1ndez Herrrero. Solicitante: FAES FARMA, SA.
\nN\u00famero de registro: EP 20382701.9 (Prioridad XX.XX.2020). Fecha de presentaci\u00f3n: 30 de julio de 2020. Lugar de presentaci\u00f3n: Canadian Intellectual Property Office.\n

Doctoral theses directed by a member of the group and read or diposited in 2020: 6 PhD students successfully defended their theses. Active doctoral theses directed by a member of the group: 10 PhD students.<\/p>\n

Several members of our group are involved in teaching activities for degrees, Master degrees and specialized courses since 2015. In a proposal of continuous training, members of our team yearly attend to international and national workshops organized by scientific organisms.<\/p>\n\t\t\t\t\"Padull\u00e9s\n

\n\t\tPadull\u00e9s Zamora, N\u00faria\n\t<\/h4>\n

\n\t\t\n\t\tnpadulles@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n

\n\t\tPrincipal investigators\n\t<\/h2>\n\t\t\t\t\"Padull\u00e9s\n

\n\t\tPadull\u00e9s Zamora, N\u00faria\n\t<\/h4>\n

\n\t\t\n\t\tnpadulles@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\"Beatriz-Candas-Estebanez\"\n

\n\t\tCandas Estebanez, Beatriz\n\t<\/h4>\n

\n\t\t\n\t\tbcandas@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\"llop-talaveron-josep\"\n

\n\t\tLlop Talaveron, Josep\n\t<\/h4>\n

\n\t\t\n\t\tjllop@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\"avatar\"\n

\n\t\tLeiva Badosa, Elisabet\n\t<\/h4>\n

\n\t\t\n\t\teleiva@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\"Helena-Colom-Codina\"\n

\n\t\tColom Codina, Helena\n\t<\/h4>\n

\n\t\t\n\t\thcolom@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\"avatar\"\n

\n\t\tAlia Ramos, Pedro\n\t<\/h4>\n

\n\t\t\n\t\tpalia@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n

\n\t\tRELATED LINKS\n\t<\/h4>\n

\n\t\t\n\t\tService of Development of Medicines (SDM)\n\t\t<\/a>\n\t<\/h4>\n

\n\t\t\n\t\tGrup de Recerca Farmacocin\u00e8tica poblacional\n\t\t<\/a>\n\t<\/h4>\n

\n\t\t\n\t\t@ElisabetLeiva\n\t\t<\/a>\n\t<\/h4>\n

\n\t\tTeam\n\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\tGroup leaders\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPrincipal investigators\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tClinical researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPredoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tManagement support\t\t\t\t<\/a>\n\t\t\t\t\t\tGroup leaders\n\t\t\t\t\t\t\t\t\t\t\t