{"id":2764,"date":"2019-10-07T23:45:16","date_gmt":"2019-10-07T21:45:16","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2764"},"modified":"2024-12-17T12:41:12","modified_gmt":"2024-12-17T11:41:12","slug":"systemic-vascular-diseases-and-ageing","status":"publish","type":"page","link":"https:\/\/idibell.cat\/en\/research\/translational-medicine-area\/cardiovascular-respiratory-and-systemic-diseases-and-cellular-aging-program\/systemic-vascular-diseases-and-ageing\/","title":{"rendered":"Systemic, Vascular Diseases and Ageing"},"content":{"rendered":"\n

\n\t\tSystemic, vascular diseases and ageing\n\t<\/h1>\n

\n\t\tSummary\n\t<\/h3>\n\t

The Systemic, Vascular Diseases and Ageing group studies the impact and treatment of systemic diseases (i.e. diseases affecting more than one organ) from the clinical and epidemiological perspective to the lab setting. Its area of experience includes the fields of systemic autoimmune diseases, venous thromboembolic disease, ageing (mainly chronic heart failure) and hemorrhagic hereditary telangiectasia and other vascular rare diseases. Regarding rare diseases, this group also studies these diseases from the basic research, with cellular and animal models. In fact, we practice a real translational research, transfering the insights from a laboratory environment into a clinical one, avoiding any gap in the transition between both settings.<\/p>\n

1452<\/h2>\n

Publications<\/h2>\n\t\t\t\t\"10825875005_5e6b57688a_b\"\n\t\t\t\t\tStrategic lines<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\tAutoimmune, autoinflammatory and systemic diseases
\nChronicity and aging
\nVenous thromboembolic disease
\nHereditary hemorrhagic telangiectasia and other vascular rare diseases
\nMinority vascular and storage diseases
\nAdult immunopathies
\nAllergology
\nCardiovascular risk factors and atherosclerosis
\nComplex dyslipidemias
\nAngiogenesis and blood vessel remodeling
\nLeukocyte extravasation and inflammation\n\t\t\t\t\t
Selected Publications<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t

Arribas V, Onetti Y, Ramiro-Pareta M, Villacampa P, Beck H, Alberola M, Esteve-Codina A, Merkel A, Sperandio M, Mart\u00ednez-Estrada OM, Schmid B, Montanez E. Endothelial TDP-43 controls sprouting angiogenesis and vascular barrier integrity, and its deletion triggers neuroinflammation<\/strong>. JCI Insight. 2024 Feb 1:e177819. doi: 10.1172\/jci.insight.177819. Epub ahead of print. PMID: 38300714.<\/p>\n

Cand\u00e1s-Est\u00e9banez B, Fern\u00e1ndez-Cid\u00f3n B, Corbella E, Teb\u00e9 C, Fanlo-Maresma M, Esteve-Luque V, Salas-Salvad\u00f3 J, Fit\u00f3 M, Riera-Mestre A, Ros E, Pint\u00f3 X. The Impact of the Mediterranean Diet and Lifestyle Intervention on Lipoprotein Subclass Profiles among Metabolic Syndrome Patients: Findings of a Randomized Controlled Trial.<\/strong> Int J Mol Sci. 2024 Jan 22;25(2):1338. doi: 10.3390\/ijms25021338. PMID: 38279337; PMCID: PMC10817060.<\/p>\n

Genet G, Genet N, Paila U, Cain SR, Cwiek A, Chavkin NW, Serbulea V, Figueras A, Cerd\u00e0 P, McDonnell SP, Sankaranarayanan D, Huba M, Nelson EA, Riera-Mestre A, Hirschi KK. Induced Endothelial Cell CycleArrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia<\/strong>. Circulation. 2023 Dec 21. doi: 10.1161\/CIRCULATIONAHA.122.062952. Epub ahead of print. PMID: 38126211.<\/p>\n

Bastard P, Vazquez S, Liu J, Laurie MT, Wang CY, Gervais A, Le Voyer T, Bizien L, Zamecnik C, Philippot Q, Rosain J, Catherinot E, Willmore A, Mitchell AM, Bair R, Gar\u00e7on P, Kenney H, Fekkar A, Salagianni M, Poulakou G, Siouti E, Sahanic S, Tancevski I, Weiss G, Nagl L, Manry J, Duvlis S, Arroyo S\u00e1nchez D, Paz Artal E, Rubio L, Perani C, Bezzi M, Sottini A, Quaresima V, Roussel L, Vinh DC, Reyes LF, Garzaro M, Hatipoglu N, Boutboul D, Tandjaoui Lambiotte Y, Borghesi A, Aliberti A, Cassaniti I, Venet F, Monneret G, Halwani R, Sharif Askari NS, Danielson J, Burrel S, Morbieu C, Stepanovskyy Y, Bondarenko A, Volokha A, Boyarchuk O, Gagro A, Neuville M, Neven B, Hernu R, Bal A, Novelli A, Novelli G, Saker K, Ailioaie O, Antol\u00ed A, Jeziorski E, Rocamora Blanch G, Teixeira C, Delaunay C, Lhuillier M, Le Turnier P, Zhang Y, Mahevas M, Pan Hammarstr\u00f6m Q, Abolhassani H, Bompoil T, Dorgham K, COVID HGE consortium \u2020, French COVID study group \u2020, COMET consortium \u2020, Gorochov G, Laouenan C, Rodr\u00edguez Gallego C, NGLFP, Renia L, Pujol A, Belot A, Raffi F, Allende LM, Martinez Picado J, Ozcelik T, Keles S, Imberti L, Notarangelo LD, Troya J, Solanich X, Zhang SY, Puel A, Wilson MR, Trouillet Assant S, Abel L, Jouanguy E, Ye CJ, Cobat A, Thompson LM, Andreakos E, Zhang Q, Anderson MS, Casanova JL, DeRisi JL. Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs<\/strong>. Sci. Immunol. 2022;doi:10.1126\/sciimmunol.abp8966.<\/p>\n

Corsonello A, Soraci L, \u00c4rnl\u00f6v J, Carlsson AC, Roller Wirnsberger R, Wirnsberger G, Mattace Raso F, Tap L, Formiga F, Moreno Gonz\u00e1lez R, Kostka T, Guligowska A, Artzi Medvedik R, Melzer I, Weingart C, Sieber C, Lattanzio F, Screening for among Older People across Europe (SCOPE) study investigators CKD. The relevance of geriatric assessments on the association between chronic kidney disease stages and mortality among older people: a secondary analysis of a multicentre cohort study.<\/strong> Age Ageing. 2022;51(7):doi:10.1093\/ageing\/afac168.<\/p>\n\t\t\t\t\tSelected Projects<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t

PI23\/00651. Papel de los autoanticuerpos que neutralizan interferones de tipo I en el lupus eritematoso sist\u00e9mico<\/strong>. AES2023. Budget: 202.500,00 \u20ac. 2024-2026. PI:\u00a0 Solanich Moreno, Xavier<\/p>\n

PID2022-141840OB-I00. Deciphering the role of TDP-43 in angiogenesis, vascular barrier and homostasis of blood vessels under both physiological and pathological conditions.<\/strong> (NeuVasTDP43). Budget: 200.000\u20ac. 2023-2026. PI: Monta\u00f1ez Miralles, Eloi.<\/p>\n

CNS2023-144390. Caracterizaci\u00f3n de un nuevo modelo animal de fibrosis retinal mediada por pericitos.<\/strong> Consolidaci\u00f3n Investigadora 2023 (MCINN). Budget: 199.890,34 \u20ac 2023-2025. PI:\u00a0 Villacampa Alcubierre, Pilar.<\/p>\n

PI23\/00164. Nuevo conocimiento en el desarrollo de malformaciones vasculares hep\u00e1ticas en los pacientes con Telangiectasia Hemorr\u00e1gica Hereditaria<\/strong> . Proyectos de investigaci\u00f3n en Salud (AES 2023).\u00a0 Budget: 167.500\u20ac. 2024-2027. PI: Riera Mestre, Antoni.<\/p>\n

2023-713-1. Desxifrar el paper de TDP-43 en la barrera vascular i l’estabilitat dels vasos sanguinis<\/strong>. La Marat\u00f3 TV3 2022. Budget: 120.000\u20ac. PI: Monta\u00f1ez Miralles, Eloi.<\/p>\n\t\t\t\t\"Riera\n

\n\t\tRiera Mestre, Antoni\n\t<\/h4>\n

\n\t\t\n\t\tariera@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n

\n\t\tPrincipal investigators\n\t<\/h2>\n\t\t\t\t\"Riera\n

\n\t\tRiera Mestre, Antoni\n\t<\/h4>\n

\n\t\t\n\t\tariera@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\"XavierPinto-Sala\"\n

\n\t\tPint\u00f3 Sala, Xavier\n\t<\/h4>\n

\n\t\t\n\t\txpinto@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\"Xavier-Solanich-Moreno\"\n

\n\t\tSolanich Moreno, Xavier\n\t<\/h4>\n

\n\t\t\n\t\txsolanich@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\"Eloi-Monta\u00f1ez-Miralles\"\n

\n\t\tMonta\u00f1ez Miralles, Eloi\n\t<\/h4>\n

\n\t\t\n\t\temontanez@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\"Francesc-Formiga-Perez\"\n

\n\t\tFormiga P\u00e9rez, Francesc\n\t<\/h4>\n

\n\t\t\n\t\tfformiga@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\"Pilar-Villacampa-Alcubierre\"\n

\n\t\tVillacampa Alcubierre, Pilar\n\t<\/h4>\n

\n\t\t\n\t\tpvillacampa@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\"Ramon\n

\n\t\tLleonart Bellfill, Ramon\n\t<\/h4>\n

\n\t\t\n\t\trlleonart@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\"Foto\n

\n\t\tCastro Castro, M\u00aa Jos\u00e9\n\t<\/h4>\n

\n\t\tRELATED LINKS\n\t<\/h4>\n

\n\t\t\n\t\tBloc Antoni Riera-Mestre\n\t\t<\/a>\n\t<\/h4>\n

\n\t\t\n\t\t@FormigaFrancesc\n\t\t<\/a>\n\t<\/h4>\n

\n\t\t\n\t\t@ramcat61\n\t\t<\/a>\n\t<\/h4>\n

\n\t\t\n\t\t@InternaHub\n\t\t<\/a>\n\t<\/h4>\n

\n\t\t\n\t\tIG InternaHub\n\t\t<\/a>\n\t<\/h4>\n

\n\t\t\n\t\tThreads InternaHub\n\t\t<\/a>\n\t<\/h4>\n

\n\t\tTeam\n\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\tGroup leaders\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPrincipal investigators\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tClinical researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPostdoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPredoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tScientific support\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tCollaborators\t\t\t\t<\/a>\n\t\t\t\t\t\tGroup leaders\n\t\t\t\t\t\t\t\t\t\t\t