{"id":2669,"date":"2019-10-07T14:19:01","date_gmt":"2019-10-07T12:19:01","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2669"},"modified":"2024-02-16T09:10:53","modified_gmt":"2024-02-16T08:10:53","slug":"physiology-and-pathology-of-the-functional-relationship-between-glia-and-neurons","status":"publish","type":"page","link":"https:\/\/idibell.cat\/en\/research\/translational-medicine-area\/genes-disease-and-therapy-program\/physiology-and-pathology-of-the-functional-relationship-between-glia-and-neurons\/","title":{"rendered":"Physiology and pathology of the functional relationship between glia and neurons"},"content":{"rendered":"\n<h1>\n\t\tPhysiology and pathology of the functional relationship between glia and neurons\n\t<\/h1>\n<h3>\n\t\tSummary\n\t<\/h3>\n\t<p>Chloride is the most abundant anion in organisms. The plasma-membrane chloride channels of the CLC and LRRC8 family are important for various physiological functions, such as regulation of nerve- and muscle-cell excitability, both in terms of cell-volume regulation and transepithelial transport. The physiological roles of various chloride channels are illustrated in human hereditary diseases caused by mutations in the genes or auxiliary subunits which regulate their functions. This group&#8217;s aim is therefore to try to understand chloride-channel regulation in order to provide therapeutic solutions to patients affected by this. The group has a multidisciplinary approach, applying imaging methods, electrophysiology and biochemistry in mice and zebrafish models.<\/p>\n<h2>73<\/h2>\n<h2>Publications<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/04\/rat_hippocampus_stained_with_antibody_to_neun_green_myelin_basic_protein_red_and_dna_blue.jpg\" alt=\"rat_hippocampus_stained_with_antibody_to_neun_green_myelin_basic_protein_red_and_dna_blue\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"rat_hippocampus_stained_with_antibody_to_neun_green_myelin_basic_protein_red_and_dna_blue\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">Strategic lines<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\"><i>Expand<\/i><\/a>\n\t\t\t\t\tThe role of glial chloride channels in brain homeostasis.<br \/>\nRare genetic diseases caused by chloride-channel dysfunction.<br \/>\nRegulation of ion channels by regulatory proteins. Structure-function of ion channels and development of specific inhibitors targeting ion channels\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Selected Publications<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<p>Wang,BB;Xu,H;Isenmann,S;Huang,C;Elorza Vidal,X;Rychkov,GY;Est\u00e9vez,R et al, <strong>Ubr1-induced selective endophagy\/autophagy protects against the endosomal and Ca(2+)-induced proteostasis disease stress<\/strong>., Cell. Mol. Life Sci., 2022;79(3):167-167, doi:10.1007\/s00018-022-04191-8<\/p>\n<p>Pla Casillanis,A;Ferigle,L;Alonso Gard\u00f3n,M;Xicoy Espaulella,E;Errasti Murugarren,E;Marazziti,D;Est\u00e9vez,R, <strong>GPR37 Receptors and Megalencephalic Leukoencephalopathy with Subcortical Cysts<\/strong>., Int. J. Mol. Sci., 2022;23(10):doi:10.3390\/ijms23105528<\/p>\n<p>Formaggio,F;Fazzina,M;Est\u00e9vez,R;Caprini,M;Ferroni,S, <strong>Dynamic expression of homeostatic ion channels in differentiated cortical astrocytes in vitro<\/strong>., Pflugers Arch., 2022;474(2):243-260, doi:10.1007\/s00424-021-02627-x<\/p>\n<p>Alonso Gardon M, Elorza Vidal X, Castellanos A, La Sala G, Armand Ugon M, Gilbert A, Di Pietro C, Pla Casillanis A, Ciruela F, Gasull X, Nunes V, Martinez A, Schulte U, Cohen Salmon M, Marazziti D, Estevez R. <strong>Identification of the GlialCAM interactome: the G protein-coupled receptors GPRC5B and GPR37L1 modulate megalencephalic leukoencephalopathy proteins<\/strong>. Hum. Mol. Genet. 2021;30(17):1649-1665. doi:10.1093\/hmg\/ddab155.<\/p>\n<p>Bosch A, Estevez R. <strong>Megalencephalic Leukoencephalopathy: Insights Into Pathophysiology and Perspectives for Therapy<\/strong>. Front Cell Neurosci. 2021;14627887-627887. doi:10.3389\/fncel.2020.627887.<\/p>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Selected Projects<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<p>&#8211; 18MAR001. Development of novel inhibitors of the chloride channel LRRC8\/VRAC, a novel player in ischemia. (201710.30). FUNDACIO IDIBELL; FUNDACI\u00d3 LA MARAT\u00d3 DE TV3; UNIVERSITAT DE BARCELONA. Importe Concedido:199.936,53\u20ac 2018-2021. IP:ESTEVEZ POVEDANO,RAUL.<\/p>\n<p>&#8211; Regulation of chloride channels in health and disease. UB. MICINN. 242000 \u20ac. 2019-2021<\/p>\n<p>&#8211; Estudios iniciales para determinar la estructura 3D de MLC1. CIBERER. 40000 \u20ac 2020-2021<\/p>\n<p>&#8211; Characterization of a zebrafish model of myotonia congenita. CIBERER. 40000 \u20ac 2021-2022<\/p>\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2019\/10\/estevez-povedano-raul-150x150.jpg\" alt=\"Estevez Povedano, Raul\" itemprop=\"image\" title=\"estevez-povedano-raul\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tEstevez Povedano, Raul\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:restevez@idibell.cat\" title=\"restevez@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\trestevez@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tPrincipal investigators\n\t<\/h2>\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2019\/10\/estevez-povedano-raul-150x150.jpg\" alt=\"Estevez Povedano, Raul\" itemprop=\"image\" title=\"estevez-povedano-raul\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tEstevez Povedano, Raul\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:restevez@idibell.cat\" title=\"restevez@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\trestevez@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2023\/11\/Tania-Lopez-Hernandez.jpg\" alt=\"Tania-L\u00f3pez-Hern\u00e1ndez\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Tania-L\u00f3pez-Hern\u00e1ndez\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tL\u00f3pez Hern\u00e1ndez, Tania\n\t<\/h4>\n<h2>\n\t\tTeam\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tGroup leaders\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPrincipal investigators\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPostdoctoral investigators\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPredoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\tGroup leaders\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Estevez Povedano, Raul<\/li>\n<\/ul>\n\t\t\t\t\t\tPrincipal investigators\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>L\u00f3pez Hern\u00e1ndez, Tania<\/li>\n<\/ul>\n\t\t\t\t\t\tPostdoctoral investigators\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Gait\u00e1n Pe\u00f1as, H\u00e9ctor<\/li>\n<li>Pla Casillanis, Adri\u00e0<\/li>\n<\/ul>\n\t\t\t\t\t\tPredoctoral researchers\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Ferigle Burgada, Laura<\/li>\n<\/ul>\n<h2>\n\t\tRelated news\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/19143\" content=\"The first gene therapy approach for MLC leukoencephalopathy, designated as an orphan drug\" \/><meta itemprop=\"datePublished\" content=\"2021-11-19\" \/><meta itemprop=\"dateModified\" content=\"2021-11-19\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2021\/11\/NdP-medicamento-hue\u0301rfano-MLC-191121_Imatge.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2021\/11\/the-first-gene-therapy-approach-for-mlc-leukoencephalopathy-designated-as-an-orphan-drug\/\" title=\"The first gene therapy approach for MLC leukoencephalopathy, designated as an orphan drug\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2021\/11\/the-first-gene-therapy-approach-for-mlc-leukoencephalopathy-designated-as-an-orphan-drug\/\" title=\"The first gene therapy approach for MLC leukoencephalopathy, designated as an orphan drug\">The first gene therapy approach for MLC leukoencephalopathy, designated as an orphan drug<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t19\/11\/2021\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/18111\" content=\"Identified two new genes implicated in developmental brain diseases\" \/><meta itemprop=\"datePublished\" content=\"2021-08-10\" \/><meta itemprop=\"dateModified\" content=\"2021-08-10\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2021\/08\/Raul-Estevez_2021B.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2021\/08\/identified-two-new-genes-implicated-in-developmental-brain-diseases\/\" title=\"Identified two new genes implicated in developmental brain diseases\"><\/a>\n\t\t\t<a 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itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/6211\" content=\"About 7 % of the general population suffers from compulsive buying disorder\" \/><meta itemprop=\"datePublished\" content=\"2014-01-13\" \/><meta itemprop=\"dateModified\" content=\"2022-01-11\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/erigin\/\" \/><meta itemprop=\"name\" content=\"Idibell\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2014\/01\/cape-town-gb3659d4c3_1920-1-1.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2014\/01\/about-7-of-the-general-population-suffers-from-compulsive-buying-disorder\/\" title=\"About 7 % of the general population suffers from compulsive buying disorder\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2014\/01\/about-7-of-the-general-population-suffers-from-compulsive-buying-disorder\/\" title=\"About 7 % of the general population suffers from compulsive buying disorder\">About 7 % of the general population suffers from compulsive buying disorder<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/erigin\/\">Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t13\/01\/2014\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/6726\" content=\"Step forward in research into new treatments for brain edema\" \/><meta itemprop=\"datePublished\" content=\"2012-03-19\" \/><meta itemprop=\"dateModified\" content=\"2023-03-02\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/erigin\/\" \/><meta itemprop=\"name\" content=\"Idibell\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2012\/03\/Clipboard-3.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2012\/03\/step-forward-in-research-into-new-treatments-for-brain-edema\/\" title=\"Step forward in research into new treatments for brain edema\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2012\/03\/step-forward-in-research-into-new-treatments-for-brain-edema\/\" title=\"Step forward in research into new treatments for brain edema\">Step forward in research into new treatments for brain edema<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/erigin\/\">Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t19\/03\/2012\t\t\t\t\t\t\t\n\t\t<!-- .pp-content-posts -->\n\n","protected":false},"excerpt":{"rendered":"<p>Physiology and pathology of the functional relationship between glia and neurons Summary Chloride is the most abundant anion in organisms. The plasma-membrane chloride channels of the CLC and LRRC8 family are important for various physiological functions, such as regulation of nerve- and muscle-cell excitability, both in terms of cell-volume regulation and transepithelial transport. 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