{"id":2605,"date":"2019-10-06T23:36:11","date_gmt":"2019-10-06T21:36:11","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2605"},"modified":"2024-06-27T15:55:38","modified_gmt":"2024-06-27T13:55:38","slug":"cell-signalling-and-bone-biology","status":"publish","type":"page","link":"https:\/\/idibell.cat\/en\/research\/translational-medicine-area\/diabetes-and-metabolism-program\/cell-signalling-and-bone-biology\/","title":{"rendered":"Cell signalling and bone biology"},"content":{"rendered":"\n<h1>\n\t\tCell signalling and bone biology\n\t<\/h1>\n<h3>\n\t\tSummary\n\t<\/h3>\n\tOur goal is to understand the signaling pathways involved in cell communication. We focus on how alterations in signaling can alter metabolism, pathophysiology, and bone regeneration, with the aim of finding new therapies by modification of these pathways.<br \/>\nThis group is an association of two independent teams at the University of Barcelona; the group led by Dr. Jose Luis Rosa focusing on &#8220;Ubiquitin ligases in health and disease&#8221;, and the laboratory of &#8220;Signaling and bone biology&#8221; led by Dr. Francesc Ventura.\n<h2>212<\/h2>\n<h2>Publications<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/04\/403senyalitzaciocelularbiologiaos.jpg\" alt=\"403senyalitzaciocelularbiologiaos\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"403senyalitzaciocelularbiologiaos\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">Strategic lines<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<p>1.- Ubiquitination and cell signalling (Jos\u00e9 Luis Rosa):<\/p>\n<p>Study of the signalling pathways involved in proliferation and differentiation regulated by ubiquitin ligases.<\/p>\n<p>Physiological and pathological relevance of HERC ubiquitin ligases.<\/p>\n<p>2.- Bone pathophysiology, bone regeneration and osteointegration (Francesc Ventura):<\/p>\n<p>Bone pathophysiology, bone regeneration and osseointegration: Metabolic reprogramming in bone development.<\/p>\n<p>Pathophysiology and therapeutic alternatives for the treatment of progressive ossifying fibrodysplasia (FOP).<\/p>\n<p>Stem cells and scaffold generation as a therapeutic strategy for bone tissue engineering.<\/p>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Selected Publications<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Pimenta Lopes,C;S\u00e1nchez Diego,C;Deber,A;Egea Cort\u00e9s,A;Valer,JA;Alcal\u00e1,A;M\u00e9ndez Lucas,A et al, <strong>Inhibition of C5AR1 impairs osteoclast mobilization and prevents bone loss<\/strong>., Mol. Ther., 2023;31(8):2507-2523, doi:10.1016\/j.ymthe.2023.04.022<\/li>\n<li>Pedrazza,L;Martinez,A;Sanchez Diego,C;Valer,JA;Pimenta Lopes,C;Sala Gaston,J;Szpak,M et al, <strong>HERC1 deficiency causes osteopenia through transcriptional program dysregulation during bone remodeling<\/strong>, Cell Death Dis., 2023;14(1):17-17, doi:10.1038\/s41419-023-05549-x<\/li>\n<li>Jos\u00e9 Antonio ValerAlexandre DeberMarius WitsCarolina Pimenta-LopesMarie-Jos\u00e9 GoumansJos\u00e9 Luis RosaGonzalo S\u00e1nchez-DuffhuesFrancesc Ventura, <strong>PI3K\u03b1 inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification, <\/strong>eLife,2023, 12:RP91779. , doi: 10.7554\/eLife.91779.1<\/li>\n<li>Villanueva Carmona,T;Cedo,L;Madeira,A;Ceperuelo Mallafre,V;Rodriguez Pena,MM;Nunez Roa,C;Maymo Masip,E et al, <strong>SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression<\/strong>, Cell Metab., 2023;35(4):doi:10.1016\/j.cmet.2023.03.004<\/li>\n<li>Sanz Serrano,D;Sanchez Diego,C;Mercade,M;Ventura,F, <strong>Dental Stem Cells SV40, a new cell line developed in vitro from human stem cells of the apical papilla<\/strong>, Int. Endod. J., 2022;56(4):502-513, doi:10.1111\/iej.13887<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">More Information<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\"><i>Expand<\/i><\/a>\n\t\t\t\t\t&#8211; Ubiquitin ligase HERC2 regulates p53 tumour protein activity.<br \/>\n&#8211; Ubiquitin ligase HERC2 is essential for embryonic development and regulates motor coordination.<br \/>\n&#8211; The function of p38 and PI3K is necessary for development and bone homeostasis.<br \/>\n&#8211; Combined treatment with BMPs and Wnt improves bone-tissue regeneration based on mesenchymal stem cells.\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2019\/10\/ventura-pujol-francesc-150x150.jpg\" alt=\"Ventura Pujol, Francesc\" itemprop=\"image\" title=\"ventura-pujol-francesc\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tVentura Pujol, Francesc\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:fventura@idibell.cat\" title=\"fventura@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tfventura@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tPrincipal investigators\n\t<\/h2>\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2019\/10\/ventura-pujol-francesc-150x150.jpg\" alt=\"Ventura Pujol, Francesc\" itemprop=\"image\" title=\"ventura-pujol-francesc\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tVentura Pujol, Francesc\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:fventura@idibell.cat\" title=\"fventura@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tfventura@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/11\/Jose-Luis-Rosa-Lopez-150x150.jpg\" alt=\"Jose-Luis-Rosa Lopez\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Jose-Luis-Rosa Lopez\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tRosa L\u00f3pez, Jos\u00e9 Luis\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:jlrosa@idibell.cat\" title=\"jlrosa@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tjlrosa@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/06\/Maria-Cristina-Manzanares-Cespedes-150x150.jpg\" alt=\"Maria-Cristina-Manzanares-C\u00e9spedes\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Maria-Cristina-Manzanares-C\u00e9spedes\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tManzanares C\u00e9spedes, Cristina\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:cmanzanares@idibell.cat\" title=\"cmanzanares@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tcmanzanares@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tTeam\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tGroup leaders\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPrincipal researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPostdoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPredoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\tGroup leaders\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Ventura Pujol, Francesc<\/li>\n<\/ul>\n\t\t\t\t\t\tPrincipal researchers\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Rosa L\u00f3pez, Jos\u00e9 Luis<\/li>\n<li>Manzanares C\u00e9spedes, Cristina<\/li>\n<\/ul>\n\t\t\t\t\t\tPostdoctoral researchers\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Dalmau Pastor, Miquel<\/li>\n<li>Pimenta Costa, Carolina<\/li>\n<\/ul>\n\t\t\t\t\t\tPredoctoral researchers\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Serra Ristol, Silvia<\/li>\n<li>Deber Lopez, Alexandre<\/li>\n<li>Costa Sastre, Laura<\/li>\n<\/ul>\n<h2>\n\t\tRelated news\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/22146\" content=\"Research team from IDIBELL and UB find that HERC1 protein deficiency causes osteopenia\" \/><meta itemprop=\"datePublished\" content=\"2023-03-03\" \/><meta itemprop=\"dateModified\" content=\"2023-03-03\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" 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content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/erigin\/\" \/><meta itemprop=\"name\" content=\"Idibell\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2013\/03\/admin-ajax-1.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2013\/03\/found-in-amish-a-genetic-mutation-causing-mental-retardation-very-similar-to-angelman-syndrome\/\" title=\"Found in Amish a genetic mutation causing mental retardation very similar to Angelman syndrome\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2013\/03\/found-in-amish-a-genetic-mutation-causing-mental-retardation-very-similar-to-angelman-syndrome\/\" title=\"Found in Amish a genetic mutation causing mental retardation very similar to Angelman syndrome\">Found in Amish a genetic mutation causing mental retardation very similar to Angelman syndrome<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/erigin\/\">Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t12\/03\/2013\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/6542\" content=\"La Marat\u00f3 de TV3 funds four IDIBELL projects\" \/><meta itemprop=\"datePublished\" content=\"2012-11-06\" \/><meta itemprop=\"dateModified\" content=\"2022-03-07\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta 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\n\t\t\t\t\t\t\t\t\t06\/11\/2012\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/7114\" content=\"IDIBELL and UB researchers identify a gene that causes movement problems in mice\" \/><meta itemprop=\"datePublished\" content=\"2010-01-12\" \/><meta itemprop=\"dateModified\" content=\"2021-10-20\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/erigin\/\" \/><meta itemprop=\"name\" content=\"Idibell\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2010\/01\/cerebelo.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2010\/01\/idibell-and-ub-researchers-identify-a-gene-that-causes-movement-problems-in-mice\/\" title=\"IDIBELL and UB researchers identify a gene that causes movement problems in mice\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2010\/01\/idibell-and-ub-researchers-identify-a-gene-that-causes-movement-problems-in-mice\/\" title=\"IDIBELL and UB researchers identify a gene that causes movement problems in mice\">IDIBELL and UB researchers identify a gene that causes movement problems in mice<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/erigin\/\">Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t12\/01\/2010\t\t\t\t\t\t\t\n\t\t<!-- .pp-content-posts -->\n\n","protected":false},"excerpt":{"rendered":"<p>Cell signalling and bone biology Summary Our goal is to understand the signaling pathways involved in cell communication. We focus on how alterations in signaling can alter metabolism, pathophysiology, and bone regeneration, with the aim of finding new therapies by modification of these pathways. This group is an association of two independent teams at the [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":540,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-2605","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2025-05-03 13:06:06","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/2605","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/comments?post=2605"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/2605\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/540"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media?parent=2605"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}