{"id":2605,"date":"2019-10-06T23:36:11","date_gmt":"2019-10-06T21:36:11","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2605"},"modified":"2024-02-16T10:11:21","modified_gmt":"2024-02-16T09:11:21","slug":"cell-signalling-and-bone-biology","status":"publish","type":"page","link":"https:\/\/idibell.cat\/en\/research\/translational-medicine-area\/diabetes-and-metabolism-program\/cell-signalling-and-bone-biology\/","title":{"rendered":"Cell signalling and bone biology"},"content":{"rendered":"\n

\n\t\tCell signalling and bone biology\n\t<\/h1>\n

\n\t\tSummary\n\t<\/h3>\n\tOur goal is to understand the signaling pathways involved in cell communication. We focus on how alterations in signaling can alter metabolism, pathophysiology, and bone regeneration, with the aim of finding new therapies by modification of these pathways.
\nThis group is an association of two independent teams at the University of Barcelona; the group led by Dr. Jose Luis Rosa focusing on “Ubiquitin ligases in health and disease”, and the laboratory of “Signaling and bone biology” led by Dr. Francesc Ventura.\n

212<\/h2>\n

Publications<\/h2>\n\t\t\t\t\"403senyalitzaciocelularbiologiaos\"\n\t\t\t\t\tStrategic lines<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t

1.- Ubiquitination and cell signalling (Jos\u00e9 Luis Rosa):<\/p>\n

Study of the signalling pathways involved in proliferation and differentiation regulated by ubiquitin ligases.<\/p>\n

Physiological and pathological relevance of HERC ubiquitin ligases.<\/p>\n

2.- Bone pathophysiology, bone regeneration and osteointegration (Francesc Ventura):<\/p>\n

Bone pathophysiology, bone regeneration and osseointegration: Metabolic reprogramming in bone development.<\/p>\n

Pathophysiology and therapeutic alternatives for the treatment of progressive ossifying fibrodysplasia (FOP).<\/p>\n

Stem cells and scaffold generation as a therapeutic strategy for bone tissue engineering.<\/p>\n\t\t\t\t\tSelected Publications<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t

Sala Gaston J, Pedrazza L, Ramirez J, Martinez A, Rawlins LE, Baple EL, Crosby AH, Mayor U, Ventura F, Rosa JL. HERC2 deficiency activates C-RAF\/MKK3\/p38 signalling pathway altering the cellular response to oxidative stress<\/strong>. Cell. Mol. Life Sci. 2022;79(11):548-548. doi:10.1007\/s00018-022-04586-7.<\/p>\n

P\u00e9rez Villegas EM, Ruiz R, Bachiller S, Ventura F, Armengol JA, Rosa JL. The HERC proteins and the nervous system<\/strong>. Semin. Cell Dev. Biol. 2022;1325-15. doi:10.1016\/j.semcdb.2021.11.017.<\/p>\n

Sanz Serrano D, Sanchez Diego C, Mercade M, Ventura F. Dental Stem Cells SV40, a new cell line developed in vitro from human stem cells of the apical papilla<\/strong>. Int. Endod. J. 2022;doi:10.1111\/iej.13887.<\/p>\n

Rodr\u00edguez Barrueco R, Latorre J, Devis J\u00e1uregui L, Lluch A, Bonifaci N, Llobet FJ, Olivan M, Coll Iglesias L, Gassner K, Davis ML, Moreno Navarrete JM, Castells Nobau A, Plata Pe\u00f1a L, Dalmau Pastor M, H\u00f6ring M, Liebisch G, Olkkonen VM, Arnoriaga Rodr\u00edguez M, Ricart W, Fern\u00e1ndez Real JM, Silva JM, Ortega FJ, Llobet Navas D. A microRNA Cluster Controls Fat Cell Differentiation and Adipose Tissue Expansion By Regulating SNCG<\/strong>. Adv Sci (Weinh). 2022;9(4):doi:10.1002\/advs.202104759.<\/p>\n

Echave MC, Erezuma I, Golafshan N, Castilho M, Kadumudi FB, Pimenta Lopes C, Ventura F, Pujol A, Jimenez JJ, Camara JA, Hern\u00e1ez Moya R, Iturriaga L, S\u00e1enz Del Burgo L, Iloro I, Azkargorta M, Elortza F, Lakshminarayanan R, Al Tel TH, Garc\u00eda P, Reyes R, Delgado A, \u00c9vora C, Pedraz JL, Dolatshahi Pirouz A, Orive G. Bioinspired gelatin\/bioceramic composites loaded with bone morphogenetic protein-2 (BMP-2) promote osteoporotic bone repair<\/strong>. Mater Sci Eng C Mater Biol Appl. 2022;134112539-112539. doi:10.1016\/j.msec.2021.112539.<\/p>\n\t\t\t\t\tMore Information<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t– Ubiquitin ligase HERC2 regulates p53 tumour protein activity.
\n– Ubiquitin ligase HERC2 is essential for embryonic development and regulates motor coordination.
\n– The function of p38 and PI3K is necessary for development and bone homeostasis.
\n– Combined treatment with BMPs and Wnt improves bone-tissue regeneration based on mesenchymal stem cells.\n\t\t\t\t\"Ventura\n

\n\t\tVentura Pujol, Francesc\n\t<\/h4>\n

\n\t\t\n\t\tfventura@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n

\n\t\tPrincipal investigators\n\t<\/h2>\n\t\t\t\t\"Ventura\n

\n\t\tVentura Pujol, Francesc\n\t<\/h4>\n

\n\t\t\n\t\tfventura@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\"Jose-Luis-Rosa\n

\n\t\tRosa L\u00f3pez, Jos\u00e9 Luis\n\t<\/h4>\n

\n\t\t\n\t\tjlrosa@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\"Maria-Cristina-Manzanares-C\u00e9spedes\"\n

\n\t\tManzanares C\u00e9spedes, Cristina\n\t<\/h4>\n

\n\t\t\n\t\tcmanzanares@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n

\n\t\tTeam\n\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\tGroup leaders\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPrincipal researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPostdoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPredoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\tGroup leaders\n\t\t\t\t\t\t\t\t\t\t\t