{"id":2605,"date":"2019-10-06T23:36:11","date_gmt":"2019-10-06T21:36:11","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2605"},"modified":"2024-06-27T15:55:38","modified_gmt":"2024-06-27T13:55:38","slug":"cell-signalling-and-bone-biology","status":"publish","type":"page","link":"https:\/\/idibell.cat\/en\/research\/translational-medicine-area\/diabetes-and-metabolism-program\/cell-signalling-and-bone-biology\/","title":{"rendered":"Cell signalling and bone biology"},"content":{"rendered":"\n
1.- Ubiquitination and cell signalling (Jos\u00e9 Luis Rosa):<\/p>\n
Study of the signalling pathways involved in proliferation and differentiation regulated by ubiquitin ligases.<\/p>\n
Physiological and pathological relevance of HERC ubiquitin ligases.<\/p>\n
2.- Bone pathophysiology, bone regeneration and osteointegration (Francesc Ventura):<\/p>\n
Bone pathophysiology, bone regeneration and osseointegration: Metabolic reprogramming in bone development.<\/p>\n
Pathophysiology and therapeutic alternatives for the treatment of progressive ossifying fibrodysplasia (FOP).<\/p>\n
Stem cells and scaffold generation as a therapeutic strategy for bone tissue engineering.<\/p>\n\t\t\t\t\tSelected Publications<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t Cell signalling and bone biology Summary Our goal is to understand the signaling pathways involved in cell communication. We focus on how alterations in signaling can alter metabolism, pathophysiology, and bone regeneration, with the aim of finding new therapies by modification of these pathways. This group is an association of two independent teams at the […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":540,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-2605","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2025-04-10 22:07:57","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/2605","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/comments?post=2605"}],"version-history":[{"count":7,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/2605\/revisions"}],"predecessor-version":[{"id":24398,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/2605\/revisions\/24398"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/540"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media?parent=2605"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}\n
\n– Ubiquitin ligase HERC2 is essential for embryonic development and regulates motor coordination.
\n– The function of p38 and PI3K is necessary for development and bone homeostasis.
\n– Combined treatment with BMPs and Wnt improves bone-tissue regeneration based on mesenchymal stem cells.\n\t\t\t\t\n
\n\t\tVentura Pujol, Francesc\n\t<\/h4>\n
\n\t\t\n\t\tfventura@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tPrincipal investigators\n\t<\/h2>\n\t\t\t\t
\n
\n\t\tVentura Pujol, Francesc\n\t<\/h4>\n
\n\t\t\n\t\tfventura@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t
\n
\n\t\tRosa L\u00f3pez, Jos\u00e9 Luis\n\t<\/h4>\n
\n\t\t\n\t\tjlrosa@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t
\n
\n\t\tManzanares C\u00e9spedes, Cristina\n\t<\/h4>\n
\n\t\t\n\t\tcmanzanares@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tTeam\n\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\tGroup leaders\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPrincipal researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPostdoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPredoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\tGroup leaders\n\t\t\t\t\t\t\t\t\t\t\t
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\n\t\tRelated news\n\t<\/h2>\n\t\t\n\t\t\t\t<\/a>\n\t\t\tResearch team from IDIBELL and UB find that HERC1 protein deficiency causes osteopenia<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t03\/03\/2023\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tNew molecular clues about a neurodevelopmental disorder with similarities to Angelman syndrome<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t15\/11\/2022\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tScientists discover an essential mechanism for maintaining bone density<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t10\/12\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tNew results on the function of the tumor suppressor HERC protein<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t20\/02\/2020\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tResearchers from the IDIBELL and the University of Barcelona describe a new treatment that could cope with two bone diseases<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t02\/08\/2019\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tDescribed novel regulator of the activity of a protein inactive in over 50% of human tumors<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t21\/07\/2014\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tFound in Amish a genetic mutation causing mental retardation very similar to Angelman syndrome<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t12\/03\/2013\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLa Marat\u00f3 de TV3 funds four IDIBELL projects<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t06\/11\/2012\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIDIBELL and UB researchers identify a gene that causes movement problems in mice<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t12\/01\/2010\t\t\t\t\t\t\t\n\t\t\n\n","protected":false},"excerpt":{"rendered":"