{"id":25071,"date":"2025-01-08T13:13:54","date_gmt":"2025-01-08T12:13:54","guid":{"rendered":"https:\/\/idibell.cat\/en\/?page_id=25071"},"modified":"2025-02-13T11:15:29","modified_gmt":"2025-02-13T10:15:29","slug":"physiology-and-pathology-of-the-functional-relationship-between-glia-and-neurons","status":"publish","type":"page","link":"https:\/\/idibell.cat\/en\/research\/neuroscience-area\/neuroscience-program\/physiology-and-pathology-of-the-functional-relationship-between-glia-and-neurons\/","title":{"rendered":"Physiology and pathology of the functional relationship between glia and neurons"},"content":{"rendered":"\n<h1>\n\t\tPhysiology and pathology of the functional relationship between glia and neurons\n\t<\/h1>\n<h3>\n\t\tSummary\n\t<\/h3>\n\t<p>Chloride is the most abundant anion in organisms. The plasma-membrane chloride channels of the CLC and LRRC8 family are important for various physiological functions, such as regulation of nerve- and muscle-cell excitability, both in terms of cell-volume regulation and transepithelial transport. The physiological roles of various chloride channels are illustrated in human hereditary diseases caused by mutations in the genes or auxiliary subunits which regulate their functions. This group&#8217;s aim is therefore to try to understand chloride-channel regulation in order to provide therapeutic solutions to patients affected by this. The group has a multidisciplinary approach, applying imaging methods, electrophysiology and biochemistry in mice and zebrafish models.<\/p>\n<h2>76<\/h2>\n<h2>Publications<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/04\/rat_hippocampus_stained_with_antibody_to_neun_green_myelin_basic_protein_red_and_dna_blue.jpg\" alt=\"rat_hippocampus_stained_with_antibody_to_neun_green_myelin_basic_protein_red_and_dna_blue\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"rat_hippocampus_stained_with_antibody_to_neun_green_myelin_basic_protein_red_and_dna_blue\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">Strategic Lines<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\tThe role of glial chloride channels in brain homeostasis.<br \/>\nRare genetic diseases caused by chloride-channel dysfunction.<br \/>\nRegulation of ion channels by regulatory proteins. Structure-function of ion channels and development of specific inhibitors targeting ion channels\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Selected Publications<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>MAYAYO VALLVERDU,C;FERIGLE BURGADA,L;VECINO PEREZ,M;Lara,J;NUNES MARTINEZ,V;Estevez Povedano,R, <strong>Characterization of an MLC patient carrying two MLC1 variants showing radiological improvement<\/strong>, Brain Disord, 2023;11100079-doi:10.1016\/j.dscb.2023.100079<\/li>\n<li>Wang,BB;Xu,H;Isenmann,S;Huang,C;Elorza Vidal,X;Rychkov,GY;Est\u00e9vez,R et al, <strong>Ubr1-induced selective endophagy\/autophagy protects against the endosomal and Ca(2+)-induced proteostasis disease stress<\/strong>., Cell. Mol. Life Sci., 2022;79(3):167-167, doi:10.1007\/s00018-022-04191-8<\/li>\n<li>Pla Casillanis,A;Ferigle,L;Alonso Gard\u00f3n,M;Xicoy Espaulella,E;Errasti Murugarren,E;Marazziti,D;Est\u00e9vez,R, <strong>GPR37 Receptors and Megalencephalic Leukoencephalopathy with Subcortical Cysts<\/strong>., Int. J. Mol. Sci., 2022;23(10):doi:10.3390\/ijms23105528<\/li>\n<li>Formaggio,F;Fazzina,M;Est\u00e9vez,R;Caprini,M;Ferroni,S, <strong>Dynamic expression of homeostatic ion channels in differentiated cortical astrocytes in vitro<\/strong>., Pflugers Arch., 2022;474(2):243-260, doi:10.1007\/s00424-021-02627-x<\/li>\n<li>Alonso Gardon M, Elorza Vidal X, Castellanos A, La Sala G, Armand Ugon M, Gilbert A, Di Pietro C, Pla Casillanis A, Ciruela F, Gasull X, Nunes V, Martinez A, Schulte U, Cohen Salmon M, Marazziti D, Estevez R. <strong>Identification of the GlialCAM interactome: the G protein-coupled receptors GPRC5B and GPR37L1 modulate megalencephalic leukoencephalopathy proteins<\/strong>. Hum. Mol. Genet. 2021;30(17):1649-1665. doi:10.1093\/hmg\/ddab155.<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Selected Projects<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>21CEE001. A Human Neural Platform for Assaying Antigen-Antibody Interactions for<br \/>\nAutoimmune Encephalitis. COMISSI\u00d3 EUROPEA. Budget: 150.000\u20ac. 2021-2023. PI: CONSIGLIO, ANTONELLA.<\/li>\n<li>LCX21001 . Characterization at the single-cell level of the neuronal response to neuroinflammatory signaling using an in-vitro co-culture system in the context of Parkinson&#8217;s disease. FUNDACI\u00d3 &#8220;LA CAIXA&#8221; . Budget: 115.092\u20ac. 2021-2024. PI: CONSIGLIO, ANTONELLA.<\/li>\n<li>21MAR008. Developing patient-tailored therapeutic candidates for rare genetic forms of pediatric parkinsonism. Fundaci\u00f3 La Marat\u00f3 de TV3 . Budget: 102.000\u20ac. 2021-2024. PI: CONSIGLIO, ANTONELLA.<\/li>\n<li>PNJ21011 . Colchine to prevent a-synuclein accumulation. INDENA S.L. Budget: 40.000\u20ac. 2021- . PI: CONSIGLIO, ANTONELLA.<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\">Technology transfer<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-3\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\tPAT083: EP 23383041.3<br \/>\nIP: Antonella Consiglio<br \/>\nNEW METHODS FOR THE DETECTION OF NEURONAL ANTIBODIES\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-4\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-4\">More information<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-4\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<p>In 2019, togheter with Dr. Raya, Antonella Consiglio received the &#8220;City of Barcelona Award&#8221; to the life sciences.<\/p>\n2021:<br \/>\n&#8211; ICREA Academy Award. 1 Jan 2020 &#8211; 31 Dec 2024; PI: Antonella Consiglio<br \/>\n&#8211; Premio de investigaci\u00f3n Merck: &#8220;&#8221;Terapia g\u00e9nica con c\u00e9lulas madre derivadas de tejido adiposo para la obesidad y enfermedades metab\u00f3licas asociadas&#8221;. PI: Laura Herrero Colaboradores: Antonella Consiglio (IDIBELL-IBUB) y N\u00faria Casals (UIC)\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2019\/10\/estevez-povedano-raul-150x150.jpg\" alt=\"Estevez Povedano, Raul\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"estevez-povedano-raul\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tEstevez Povedano, Raul\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:restevez@idibell.cat\" title=\"restevez@idibell.cat\"  target=\"_blank\"  rel=\"noopener\">\n\t\trestevez@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tPrincipal investigators\n\t<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2019\/10\/estevez-povedano-raul-150x150.jpg\" alt=\"Estevez Povedano, Raul\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"estevez-povedano-raul\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tEstevez Povedano, Raul\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:arestevez@idibell.cat\" title=\"restevez@idibell.cat\"  target=\"_blank\"  rel=\"noopener\">\n\t\trestevez@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:vmoreno@idibell.cat\" title=\"\"  target=\"_blank\"  rel=\"noopener\">\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2023\/11\/Tania-Lopez-Hernandez.jpg\" alt=\"Tania-L\u00f3pez-Hern\u00e1ndez\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Tania-L\u00f3pez-Hern\u00e1ndez\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tL\u00f3pez Hern\u00e1ndez, Tania\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/06\/Ekaitz-Errasti-Murugarren-150x150.jpg\" alt=\"Ekaitz-Errasti-Murugarren\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Ekaitz-Errasti-Murugarren\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tErrasti Murugarren, Ekaitz\n\t<\/h4>\n<h2>\n\t\tTeam\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tGroup Leaders\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPrincipal investigators\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPostdoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPredoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-4\" data-index=\"4\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-4\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tScientific support\t\t\t\t<\/a>\n\t\t\t\t\t\tGroup Leaders\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Estevez Povedano, Raul<\/li>\n<\/ul>\n\t\t\t\t\t\tPrincipal investigators\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>L\u00f3pez Hern\u00e1ndez, Tania<\/li>\n<li>Errasti Murugarren, Ekaitz<\/li>\n<\/ul>\n\t\t\t\t\t\tPostdoctoral researchers\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Gait\u00e1n Pe\u00f1as, H\u00e9ctor<\/li>\n<li>Prat Pedrola, Ester<\/li>\n<li>Mayayo Vallverdu, Clara<\/li>\n<\/ul>\n\t\t\t\t\t\tPredoctoral researchers\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Ferigle Burgada, Laura<\/li>\n<li>Mart\u00ednez Jim\u00e9nez, Adrian<\/li>\n<li>Freitas Arbo, Sandra<\/li>\n<li>Zhou, Zhixin<\/li>\n<\/ul>\n\t\t\t\t\t\tScientific support\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Vecino P\u00e9rez, Marta<\/li>\n<\/ul>\n<h2>\n\t\tRelated news\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/19143\" content=\"The first gene therapy approach for MLC leukoencephalopathy, designated as an orphan drug\" \/><meta itemprop=\"datePublished\" content=\"2021-11-19\" \/><meta itemprop=\"dateModified\" content=\"2021-11-19\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2021\/11\/NdP-medicamento-hue\u0301rfano-MLC-191121_Imatge.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" 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content=\"Identified two new genes implicated in developmental brain diseases\" \/><meta itemprop=\"datePublished\" content=\"2021-08-10\" \/><meta itemprop=\"dateModified\" content=\"2021-08-10\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2021\/08\/Raul-Estevez_2021B.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a 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advances in the study of megalencephalic leukoencephalopathy<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/erigin\/\">Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t25\/03\/2014\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/6211\" content=\"About 7 % of the general population suffers from compulsive buying disorder\" \/><meta itemprop=\"datePublished\" content=\"2014-01-13\" \/><meta itemprop=\"dateModified\" content=\"2022-01-11\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/erigin\/\" \/><meta itemprop=\"name\" content=\"Idibell\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2014\/01\/cape-town-gb3659d4c3_1920-1-1.jpg\" 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itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/6726\" content=\"Step forward in research into new treatments for brain edema\" \/><meta itemprop=\"datePublished\" content=\"2012-03-19\" \/><meta itemprop=\"dateModified\" content=\"2023-03-02\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/erigin\/\" \/><meta itemprop=\"name\" content=\"Idibell\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2012\/03\/Clipboard-3.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2012\/03\/step-forward-in-research-into-new-treatments-for-brain-edema\/\" title=\"Step forward in research into new treatments for brain edema\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2012\/03\/step-forward-in-research-into-new-treatments-for-brain-edema\/\" title=\"Step forward in research into new treatments for brain edema\">Step forward in research into new treatments for brain edema<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/erigin\/\">Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t19\/03\/2012\t\t\t\t\t\t\t\n\t\t<!-- .pp-content-posts -->\n\n","protected":false},"excerpt":{"rendered":"<p>Physiology and pathology of the functional relationship between glia and neurons Summary Chloride is the most abundant anion in organisms. The plasma-membrane chloride channels of the CLC and LRRC8 family are important for various physiological functions, such as regulation of nerve- and muscle-cell excitability, both in terms of cell-volume regulation and transepithelial transport. 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