{"id":2455,"date":"2019-10-06T05:02:30","date_gmt":"2019-10-06T03:02:30","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2455"},"modified":"2024-06-19T15:03:12","modified_gmt":"2024-06-19T13:03:12","slug":"molecular-signaling-in-cancer","status":"publish","type":"page","link":"https:\/\/idibell.cat\/en\/research\/cancer-area\/molecular-mechanisms-and-experimental-therapy-in-oncology-program-oncobell\/molecular-signaling-in-cancer\/","title":{"rendered":"Molecular signaling in Cancer"},"content":{"rendered":"\n

\n\t\tMolecular signaling in cancer\n\t<\/h1>\n

\n\t\tSummary\n\t<\/h3>\n\t

The molecular signaling cascades which are produced at the cell level are essential for responding to changes in its environment or to alter its homeostasis, e.g. at the cell proliferation, movement, growth or metabolism levels. Understanding the mechanism of signal transduction enables us to explain how the alterations produced in many pathologies are controlled. As such, the changes in signalling can be used to detect the presence of many diseases and the signalling molecules can become therapeutic targets. Furthermore, these signalling pathways are affected in response to therapies used to treat diseases such as cancer, and are involved in creating drug resistance.<\/p>\n

176<\/h2>\n

Publications<\/h2>\n\t\t\t\t\"southern_blot_membrane\"\n\t\t\t\t\tStrategic lines<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\tThe role of different signalling pathways in physiological processes: how members of the TGFbeta and EGFR families control angiogenesis, or the role of different ubiquitin ligases which regulate signalling protein function.
\nEpithelial ovarian cancer: the role of different receptor tyrosine kinases (such as PDGF or c-Kit receptors) and cytokine receptors (such as CXCR4) in the development and metastasis of this type of cancer.
\nParticipation of different signalling pathways and metabolic changes in creating chemotherapy resistance in ovarian, testicular and epithelial cancers.
\nModification of cellular pH using anionophoric substances as a new therapeutic strategy for lung cancer treatment.
\nPreclinical development of novel anticancer drugs against therapeutic targets related to treatment resistance.
\nEvaluation of new drug delivery systems for cancer treatment by nanoencapsulation of antitumor compounds.\n\t\t\t\t\tSelected Publications<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t