{"id":2403,"date":"2019-10-06T00:24:35","date_gmt":"2019-10-05T22:24:35","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2403"},"modified":"2024-06-10T10:54:27","modified_gmt":"2024-06-10T08:54:27","slug":"tumor-and-stromal-chemoresistance","status":"publish","type":"page","link":"https:\/\/idibell.cat\/en\/research\/cancer-area\/molecular-mechanisms-and-experimental-therapy-in-oncology-program-oncobell\/tumor-and-stromal-chemoresistance\/","title":{"rendered":"Tumor and stromal chemoresistance"},"content":{"rendered":"\n<h1>\n\t\tTumor and stromal chemoresistance\n\t<\/h1>\n<h3>\n\t\tSummary\n\t<\/h3>\n\t<p>Our group addresses different aspects of chemoresistance using advanced animal models (orthoxenografts) and non-tumour cell models, such as cancer-associated fibroblasts, to study mechanisms of therapeutic resistance in solid and hematological tumors.<\/p>\n<p>Orthoxenografts\u00ae are experimental mouse models in which a small piece of human tumour is implanted (implantation from one spices to another, xenograft) in the same organ of origin (orthotopically). Orthoxenografts\u00ae are characterised by reproducing the histological, genetic and molecular characteristics of the original primary tumour, representing an excellent scientific tool for predicting patient response to chemotherapy treatment, and providing treatment alternatives based on scientific evidence.<\/p>\n<p>&nbsp;<\/p>\n<h2>367<\/h2>\n<h2>Publications<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/04\/nacktmaus_01.jpg\" alt=\"nacktmaus_01\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"nacktmaus_01\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">Strategic lines<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\"><i>Expand<\/i><\/a>\n\t\t\t\t\tStudy of the genetic and epigenetic mechanisms associated with the development of resistance to chemotherapy treatment in different types of tumours. (Dr Villanueva)<br \/>\nStudy of the tumour stroma as a modulator of tumour growth and response to chemotherapy. (Dr Mollev\u00ed)<br \/>\nPreclinical evaluation of new drugs with therapeutic potential (Drs Villanueva, Mollev\u00ed and Farr\u00e9)<br \/>\nModelling of hematological cancer using humanized mouse models (Dra Farr\u00e9)\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Selected Publications<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Ortiz Barahona,V;Soler,M;Davalos,V;Garcia Prieto,CA;Janin,M;Setien,F;Fernandez Rebollo,I et al, <strong>Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer<\/strong>, Mol. Cancer, 2023;22(1):83-83, doi:10.1186\/s12943-023-01785-z<\/li>\n<li>Alvarez Sierra,D;Rodriguez Grande,J;Gomez Brey,A;Bello,I;Caubet,E;Gonzalez,O;Zafon,C et al, <strong>Single cell transcriptomic analysis of Graves&#8217; disease thyroid glands reveals the broad immunoregulatory potential of thyroid follicular and stromal cells and implies a major re-interpretation of the role of aberrant HLA class II expression in autoimmunity<\/strong>, J. Autoimmun., 2023;139103072-103072, doi:10.1016\/j.jaut.2023.103072<\/li>\n<li>Pecharrom\u00e1n,I;Sol\u00e9,L;Alvarez Villanueva,D;Lobo Jarne,T;Alonso Mara\u00f1\u00f3n,J;Bertran,J; Guill\u00e9n,Y et al, <strong>I?B kinase-a coordinates BRD4 and JAK\/STAT signaling to subvert DNA damage-based anticancer therapy<\/strong>, Embo J., 2023;42(21):doi:10.15252\/embj.2023114719,<\/li>\n<li>Amirkhah,R;Gilroy,K;Malla,SB;Lannagan,TRM;Byrne,RM;Fisher,NC;Corry,SM et al, <strong>MmCMS: mouse models&#8217; consensus molecular subtypes of colorectal cancer<\/strong>., Br. J. Cancer, 2023;128(7):1333-1343, doi:10.1038\/s41416-023-02157-6<\/li>\n<li>Creus Bachiller,E;Fern\u00e1ndez Rodr\u00edguez,J;Magall\u00f3n Lorenz,M;Ortega Bertran,S;Navas Rutete,S;Romagosa,C;Silva,TM et al, <strong>Expanding a precision medicine platform for malignant peripheral nerve sheath tumors: New patient-derived orthotopic xenografts, cell lines and tumor entities<\/strong>, Mol. Oncol., 2023;doi:10.1002\/1878-0261.13534<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Selected Projects<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>FIS22049. <strong>Identificaci\u00f3n de vulnerabilidades terap\u00e9uticas en c\u00e1ncer de ovario y pulm\u00f3n analizando las v\u00edas de reparaci\u00f3n del ADN por Excisi\u00f3n de Nucle\u00f3tidos (NER) y Recombinaci\u00f3n Hom\u00f3loga (HR)<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 214.170\u20ac. 2023-2025. PI: Villanueva Garatachea, Alberto.<\/li>\n<li>FIS21070. <strong>Evaluaci\u00f3n espacial del impacto del tratamiento neoadyuvante sobre el microambiente tumoral en las met\u00e1stasis hep\u00e1ticas de c\u00e1ncer colorectal<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 169.400\u20ac. 2022-2024. PI: GARCIA MOLLEVI, DAVID.<\/li>\n<li>20FIS014. <strong>Genetic bases of tumor cell resitance to immune checkpoint inhibitors in orthoxenografts\/ PDOX derived from three cisplatin-based treated tumors: NSCLC, bladder and ovarian cancer<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 147.620\u20ac. 2020-2023. PI: Villanueva Garatachea, Alberto.<\/li>\n<li>FIS21065. <strong>Improving Outcomes of Patients with Extramedullary Multiple Myeloma. Potential Applicability of Orthoxenograft Models in the Study of Genetic Bases of Drug Resistance<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 135.520\u20ac. 2022-2024. PI: Farre Vallve, Maria Lourdes.<\/li>\n<li>19FIS027. <strong>Reprogramaci\u00f3n de fibroblastos asociados a carcinoma intratumorales en met\u00e1stasis hep\u00e1ticas de carcinoma colorrectal<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 111.320\u20ac. 2019-2023. PI: GARCIA MOLLEVI, DAVID.<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\">Technology transfer<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\"><i>Expand<\/i><\/a>\n\t\t\t\t\tLicense: PDX<br \/>\nPI: Dr. Alberto Villanueva\nLicense: PDX models 2014-2021<br \/>\nPI: Dr. Alberto Villanueva\nSpin-off: Xenopat<br \/>\nPI: Dr. Alberto Villanueva\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-4\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-4\">More Information<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-4\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-4\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<p>Development of the spin-off Xenopat<\/p>\n<p><em>Proyectos financiados por el Instituto de Salud Carlos III (ISCIII) y cofinanciados por el Fondo Europeo de Desarrollo Regional (FEDER):<\/em><\/p>\n<strong>Desarrollo \u00a0de dispersiones solidas micro\/nanoestruturadas para administraci\u00f3n oral de compuestos marinos antitumorales.<\/strong><br \/>\nIPT-2011-0754-900000<br \/>\n05\/2011-12\/2014\u00a0\u00a0\u00a0\u00a0283.488 \u20ac<br \/>\nIP: Alberto Villanueva Garatachea\n<strong>Categorizaci\u00f3n histogen\u00e9tica de orthoxenografts de C\u00e1ncer Epitelial de Ovario (CEO): Una nueva estrategia para personalizar el tratamiento de las pacientes en tiempo real<\/strong><br \/>\nPI13\/01339. 01\/2014-04\/2017. 111.500 \u20ac. IP: Alberto Villanueva Garatachea.<br \/>\nCategorizar\/estratificar el c\u00e1ncer epitelial de ovario en subgrupos de referencia en base a la histolog\u00eda y el perfil gen\u00e9tico (histogen\u00e9tica) de los diferentes orthoxenografts, u PDX ortot\u00f3picos de c\u00e1ncer de ovario, e identificar en el rat\u00f3n para cada subgrupo la mejor opci\u00f3n terap\u00e9utica.\n<strong>Identificaci\u00f3n de un &#8220;core gen\u00e9tico b\u00e1sico&#8221; asociado con la adquisici\u00f3n de resistencia al cisplatino en orthoxenografts\u00ae de tumores de pulm\u00f3n (NSCLC), epiteliales de ovario y germinales testiculares<\/strong><br \/>\nPI16\/01898. 01\/2017-12\/2019. 136.500 \u20ac. IP: Alberto Villanueva Garatachea.<br \/>\nIdentificar en tres tipos de tumores un panel m\u00ednimo de alteraciones gen\u00e9ticas espec\u00edficas asociadas con la adquisici\u00f3n de resistencia al cisplatino (&#8220;core b\u00e1sico de resistencia&#8221;) independiente del tipo de tumor. El cisplatino es el f\u00e1rmaco base del tratamiento de muchos tipos tumorales. Un porcentaje importante de los pacientes que inicialmente responden al cisplatino recaen, haci\u00e9ndose resistentes (&#8220;resistencia adquirida&#8221;), as\u00ed como existe un subgrupo de pacientes que no responden de entrada (&#8220;tumores refractarios&#8221;). A pesar de su relevancia cl\u00ednica no hay ning\u00fan marcador predictivo de respuesta\/resistencia al cisplatino que se use en la pr\u00e1ctica cl\u00ednica.\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2019\/12\/institutodelasalud.png\" alt=\"\" width=\"249\" height=\"150\" \/><\/p>\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2019\/10\/villanueva-garatachea-alberto-150x150.jpg\" alt=\"Villanueva Garatachea, Alberto\" itemprop=\"image\" title=\"villanueva-garatachea-alberto\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tVillanueva Garatachea, Alberto\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:avillanueva@idibell.cat\" title=\"avillanueva@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tavillanueva@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2019\/10\/garcia-mollevi-david-150x150.jpg\" alt=\"garcia-mollevi-david\" itemprop=\"image\" title=\"garcia-mollevi-david\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tGarcia Mollevi, David\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:dgarcia@idibell.cat\" title=\"dgarcia@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tdgarcia@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tPrincipal investigators\n\t<\/h2>\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2019\/10\/villanueva-garatachea-alberto-150x150.jpg\" alt=\"Villanueva Garatachea, Alberto\" itemprop=\"image\" title=\"villanueva-garatachea-alberto\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tVillanueva Garatachea, Alberto\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:avillanueva@idibell.cat\" title=\"avillanueva@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tavillanueva@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2019\/10\/garcia-mollevi-david-150x150.jpg\" alt=\"garcia-mollevi-david\" itemprop=\"image\" title=\"garcia-mollevi-david\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tGarcia Mollevi, David\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:dgarcia@idibell.cat\" title=\"dgarcia@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tdgarcia@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2021\/05\/Untitled-1-150x150.jpg\" alt=\"Untitled-1\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Untitled-1\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tFarre Vallve, Mar\u00eda Lourdes\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:mfarre@idibell.cat\" title=\"mfarre@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tmfarre@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\tRELATED LINKS\n\t<\/h4>\n<h4>\n\t\t<a href=\"http:\/\/ico.gencat.cat\/ca\/recerca\/Programa-ProCURE\/index.html\" title=\"ProCURE\" target=\"_blank\" rel=\"noopener\">\n\t\tProCURE\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"http:\/\/xenopat.com\/\" title=\"Xenopat\" target=\"_blank\" rel=\"noopener\">\n\t\tXenopat\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/Xenopat_\" title=\"@Xenopat_\" target=\"_blank\" rel=\"noopener\">\n\t\t@Xenopat_\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tTeam\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tGroup leaders \t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPrincipal investigators\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\t Clinical researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPredoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-4\" data-index=\"4\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-4\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tScientific support\t\t\t\t<\/a>\n\t\t\t\t\t\tGroup leaders \n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Villanueva Garatachea, Alberto<\/li>\n<li>Garcia Mollevi, David<\/li>\n<\/ul>\n\t\t\t\t\t\tPrincipal investigators\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Farre Vallve, Mar\u00eda Lourdes<\/li>\n<\/ul>\n\t\t\t\t\t\t Clinical researchers\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Ruiz Roig, N\u00faria<\/li>\n<\/ul>\n\t\t\t\t\t\tPredoctoral researchers\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Alvarez Villanueva, Daniel<\/li>\n<li>Molina Valdelvira, Natalia<\/li>\n<\/ul>\n\t\t\t\t\t\tScientific support\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Calaf Sanjuanes, Monica<\/li>\n<li>Ba\u00f1uls Ferrando, Maria<\/li>\n<li>Martinez Iniesta, Maria<\/li>\n<\/ul>\n<h2>\n\t\tRelated news\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/23922\" content=\"An innovative therapeutic strategy to treat colon cancer is discovered\" \/><meta itemprop=\"datePublished\" content=\"2024-04-12\" \/><meta itemprop=\"dateModified\" content=\"2024-04-12\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2024\/04\/Foto2_team-scaled.jpg\" \/><meta itemprop=\"width\" content=\"2560\" \/><meta itemprop=\"height\" content=\"1280\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2024\/04\/an-innovative-therapeutic-strategy-to-treat-colon-cancer-is-discovered\/\" title=\"An innovative therapeutic strategy to treat colon cancer is discovered\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2024\/04\/an-innovative-therapeutic-strategy-to-treat-colon-cancer-is-discovered\/\" title=\"An innovative therapeutic strategy to treat colon cancer is discovered\">An innovative therapeutic strategy to treat colon cancer is discovered<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t12\/04\/2024\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/23220\" content=\"A study by IDIBELL, ICO and IGTP puts precision medicine at the service of nerve tumors\" \/><meta itemprop=\"datePublished\" content=\"2023-11-23\" \/><meta itemprop=\"dateModified\" content=\"2023-11-23\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2023\/11\/Lazaro-Villanueva-scaled.jpg\" \/><meta itemprop=\"width\" content=\"2560\" \/><meta itemprop=\"height\" content=\"1280\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2023\/11\/a-study-by-idibell-ico-and-igtp-puts-precision-medicine-at-the-service-of-nerve-tumors\/\" title=\"A study by IDIBELL, ICO and IGTP puts precision medicine at the service of nerve tumors\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2023\/11\/a-study-by-idibell-ico-and-igtp-puts-precision-medicine-at-the-service-of-nerve-tumors\/\" title=\"A study by IDIBELL, ICO and IGTP puts precision medicine at the service of nerve tumors\">A study by IDIBELL, ICO and IGTP puts precision medicine at the service of nerve tumors<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t23\/11\/2023\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/23185\" content=\"A new advance in the fight against childhood cancer\" \/><meta itemprop=\"datePublished\" content=\"2023-11-10\" \/><meta itemprop=\"dateModified\" content=\"2023-11-10\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2023\/11\/231109-Alberto-Villanueva-copia-scaled.jpg\" \/><meta itemprop=\"width\" content=\"2560\" \/><meta itemprop=\"height\" content=\"1280\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2023\/11\/a-new-advance-in-the-fight-against-childhood-cancer\/\" title=\"A new advance in the fight against childhood cancer\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2023\/11\/a-new-advance-in-the-fight-against-childhood-cancer\/\" title=\"A new advance in the fight against childhood cancer\">A new advance in the fight against childhood cancer<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t10\/11\/2023\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/23129\" content=\"Recent findings indicate a promising new therapeutic approach in the fight against cancer, involving a novel combination of treatments\" \/><meta itemprop=\"datePublished\" content=\"2023-10-26\" \/><meta itemprop=\"dateModified\" content=\"2023-10-26\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2023\/10\/Villanueva-Salazar-Co.jpg\" \/><meta itemprop=\"width\" content=\"422\" \/><meta itemprop=\"height\" content=\"238\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2023\/10\/recent-findings-indicate-a-promising-new-therapeutic-approach-in-the-fight-against-cancer-involving-a-novel-combination-of-treatments\/\" title=\"Recent findings indicate a promising new therapeutic approach in the fight against cancer, involving a novel combination of treatments\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2023\/10\/recent-findings-indicate-a-promising-new-therapeutic-approach-in-the-fight-against-cancer-involving-a-novel-combination-of-treatments\/\" title=\"Recent findings indicate a promising new therapeutic approach in the fight against cancer, involving a novel combination of treatments\">Recent findings indicate a promising new therapeutic approach in the fight against cancer, involving a novel combination of treatments<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t26\/10\/2023\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/21616\" content=\"New mouse models boost personalized treatment research in endometrial cancer\" \/><meta itemprop=\"datePublished\" content=\"2022-11-29\" \/><meta itemprop=\"dateModified\" content=\"2022-11-29\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/11\/NP28-D-Llobet_Adv-Scie-ImatgeB.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2022\/11\/new-mouse-models-boost-personalized-treatment-research-in-endometrial-cancer\/\" title=\"New mouse models boost personalized treatment research in endometrial cancer\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2022\/11\/new-mouse-models-boost-personalized-treatment-research-in-endometrial-cancer\/\" title=\"New mouse models boost personalized treatment research in endometrial cancer\">New mouse models boost personalized treatment research in endometrial cancer<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t29\/11\/2022\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/20677\" content=\"Researchers discover a set of poor prognosis markers in patients with colon and rectal cancer\" \/><meta itemprop=\"datePublished\" content=\"2022-06-03\" \/><meta itemprop=\"dateModified\" content=\"2022-06-03\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/06\/NO055-Nat-Comm_IMIM-Imatge.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2022\/06\/researchers-discover-a-set-of-poor-prognosis-markers-in-patients-with-colon-and-rectal-cancer\/\" title=\"Researchers discover a set of poor prognosis markers in patients with colon and rectal cancer\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2022\/06\/researchers-discover-a-set-of-poor-prognosis-markers-in-patients-with-colon-and-rectal-cancer\/\" title=\"Researchers discover a set of poor prognosis markers in patients with colon and rectal cancer\">Researchers discover a set of poor prognosis markers in patients with colon and rectal cancer<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t03\/06\/2022\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/20410\" content=\"A study presents MCLA-158, the first drug candidate targeting cancer stem cells from solid tumors\" \/><meta itemprop=\"datePublished\" content=\"2022-04-26\" \/><meta itemprop=\"dateModified\" content=\"2022-04-26\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/04\/NP14-R-Salazar_Nature-Medicine-Foto.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2022\/04\/a-study-presents-mcla-158-the-first-drug-candidate-targeting-cancer-stem-cells-from-solid-tumors\/\" title=\"A study presents MCLA-158, the first drug candidate targeting cancer stem cells from solid tumors\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2022\/04\/a-study-presents-mcla-158-the-first-drug-candidate-targeting-cancer-stem-cells-from-solid-tumors\/\" title=\"A study presents MCLA-158, the first drug candidate targeting cancer stem cells from solid tumors\">A study presents MCLA-158, the first drug candidate targeting cancer stem cells from solid tumors<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t26\/04\/2022\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/19769\" content=\"The generation of a stem cell-derived neurofibroma model opens the door to new treatments development\" \/><meta itemprop=\"datePublished\" content=\"2022-02-22\" \/><meta itemprop=\"dateModified\" content=\"2022-02-22\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/02\/NO20-Neurofibromes-Imatge.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2022\/02\/the-generation-of-a-stem-cell-derived-neurofibroma-model-opens-the-door-to-new-treatments-development\/\" title=\"The generation of a stem cell-derived neurofibroma model opens the door to new treatments development\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2022\/02\/the-generation-of-a-stem-cell-derived-neurofibroma-model-opens-the-door-to-new-treatments-development\/\" title=\"The generation of a stem cell-derived neurofibroma model opens the door to new treatments development\">The generation of a stem cell-derived neurofibroma model opens the door to new treatments development<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t22\/02\/2022\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/19696\" content=\"The histology of liver metastases from colon cancer could influence immunotherapy\" \/><meta itemprop=\"datePublished\" content=\"2022-02-17\" \/><meta itemprop=\"dateModified\" content=\"2022-02-17\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/02\/Imatge-Mollevi.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2022\/02\/the-histology-of-liver-metastases-from-colon-cancer-could-have-an-influence-on-immunotherapy\/\" title=\"The histology of liver metastases from colon cancer could influence immunotherapy\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2022\/02\/the-histology-of-liver-metastases-from-colon-cancer-could-have-an-influence-on-immunotherapy\/\" title=\"The histology of liver metastases from colon cancer could influence immunotherapy\">The histology of liver metastases from colon cancer could influence immunotherapy<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t17\/02\/2022\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/17869\" content=\"IDIBELL and ICO participate in the discovery of a weakness that could be used to treat defective cancers for SMARCA4\" \/><meta itemprop=\"datePublished\" content=\"2021-07-22\" \/><meta itemprop=\"dateModified\" content=\"2021-07-22\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2021\/07\/NO70-Villanueva_Nat-Com-Imatge.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2021\/07\/idibell-and-ico-participate-in-the-discovery-of-a-weakness-that-could-be-used-to-treat-defective-cancers-for-smarca4\/\" title=\"IDIBELL and ICO participate in the discovery of a weakness that could be used to treat defective cancers for SMARCA4\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2021\/07\/idibell-and-ico-participate-in-the-discovery-of-a-weakness-that-could-be-used-to-treat-defective-cancers-for-smarca4\/\" title=\"IDIBELL and ICO participate in the discovery of a weakness that could be used to treat defective cancers for SMARCA4\">IDIBELL and ICO participate in the discovery of a weakness that could be used to treat defective cancers for SMARCA4<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t22\/07\/2021\t\t\t\t\t\t\t\n\t\t<!-- .pp-content-posts -->\n\n","protected":false},"excerpt":{"rendered":"<p>Tumor and stromal chemoresistance Summary Our group addresses different aspects of chemoresistance using advanced animal models (orthoxenografts) and non-tumour cell models, such as cancer-associated fibroblasts, to study mechanisms of therapeutic resistance in solid and hematological tumors. Orthoxenografts\u00ae are experimental mouse models in which a small piece of human tumour is implanted (implantation from one spices [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":448,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-2403","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2024-12-25 10:45:04","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/2403","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/comments?post=2403"}],"version-history":[{"count":7,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/2403\/revisions"}],"predecessor-version":[{"id":24253,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/2403\/revisions\/24253"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/448"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media?parent=2403"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}