{"id":2364,"date":"2019-10-05T20:19:55","date_gmt":"2019-10-05T18:19:55","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2364"},"modified":"2024-06-19T14:38:10","modified_gmt":"2024-06-19T12:38:10","slug":"transformation-and-metastasis-2","status":"publish","type":"page","link":"https:\/\/idibell.cat\/en\/research\/cancer-area\/molecular-mechanisms-and-experimental-therapy-in-oncology-program-oncobell\/transformation-and-metastasis-2\/","title":{"rendered":"Transformation and Metastasis"},"content":{"rendered":"\n<h1>\n\t\tTransformation and metastasis\n\t<\/h1>\n<h3>\n\t\tSummary\n\t<\/h3>\n\t<p>This group&#8217;s research aims to identify new therapeutic targets for cancer which can be directly translated into effective prevention or treatment strategies. Its aim is to understand the signalling pathways involved in the epithelial stem cell fate and homeostasis, their alterations during cancer and metastasis, and the interactions between tumour cells and their microenvironment.<\/p>\n<p>The experience of the group&#8217;s members includes mammary-gland development, breast cancer and immunology.<\/p>\n<p>\u00a0The group has a multidisciplinary focus and uses genetically modified mice models, patient-derived xenografts, clinical samples, organoids and 3D cultures, and molecular and cellular biology techniques to translate basic research into relevant clinical results.<\/p>\n<p>&nbsp;<\/p>\n<h2>147<\/h2>\n<h2>Publications<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/04\/608_gonzalez2.jpg\" alt=\"608_gonzalez2\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"608_gonzalez2\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">Strategic lines<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\"><i>Expand<\/i><\/a>\n\t\t\t\t\t\u2022 To identify new therapeutic strategies and mechanisms of resistance to current treatments for breast cancer<br \/>\n\u2022 To evaluate the role of the RANK signalling pathway in epithelial homeostasis, inflammation and cancer, and its potential as a therapeutic target.\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Selected Publications<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Rocha,AS;Collado Sol\u00e9,A;Gra\u00f1a Castro,O;Redondo Pedraza,J;Soria Alcaide,G; Cordero,A; Santamaria,PG et al, <strong>Luminal Rank loss decreases cell fitness leading to basal cell bipotency in parous mammary glands<\/strong>, Nat. Commun., 2023;14(1):6213-6213, doi:10.1038\/s41467-023-41741-5<\/li>\n<li>Ciscar,M;Trinidad,EM;Perez Chacon,G;Alsaleem,M;Jimenez,M;Jimenez Santos,MJ;Perez Montoyo,H et al, <strong>RANK is a poor prognosis marker and a therapeutic target in ER-negative postmenopausal breast cancer<\/strong>., EMBO Mol. Med., 2023;15(4):doi:10.15252\/emmm.202216715<\/li>\n<li>Garcia Tejedor,A;Ortega Exposito,C;Salinas,S;Luzardo Gonzalez,A;Falo,C;Martinez Perez,E;Perez Montero,H et al, <strong>Axillary lymph node dissection versus radiotherapy in breast cancer with positive sentinel nodes after neoadjuvant therapy (ADARNAT trial)<\/strong>, Front. Oncol., 2023;131184021-1184021, doi:10.3389\/fonc.2023.1184021<\/li>\n<li>Cordero,A;Santamaria,PG;Gonzalez Suarez,E, <strong>Rank ectopic expression in the presence of Neu and MMTV oncogenes alters mammary epithelial cell populations and their tumorigenic potential<\/strong>, J. Mammary Gland Biol. Neoplasia, 2023;28(1):2-2, doi:10.1007\/s10911-023-09530-4<\/li>\n<li>Gomes,I;Gallego Paez,LM;Jim\u00e9nez,M;Santamaria,PG;Mansinho,A;Sousa,R;Abreu,C et al, <strong>Co-targeting RANK pathway treats and prevents acquired resistance to CDK4\/6 inhibitors in luminal breast cancer<\/strong>, Cell Rep. Med., 2023;4(8):101120-101120, doi:10.1016\/j.xcrm.2023.101120<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Selected Projects<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>16CEE012. <strong>PLEIO-RANK:Pleiotropic treatment of cancer: RANK inhibitors targeting cancer stem cells and immunity<\/strong>. COMISSI\u00d3 EUROPEA. Budget: 1.999.960,01\u20ac. 2016-2023. PI: GONZALEZ SUAREZ, EVA.<\/li>\n<li>17PRV003.<strong> An open label biomarker pilot study of the antitumoral activity of denosumab in the pre- operative setting of early breast cancer<\/strong>. Amgen Inc. Budget: 517.652\u20ac. 2019-2023. PI: Eva Gonzalez Suarez.<\/li>\n<li>2024-099-1. <strong>ESTUDIO EN FASE III, ABIERTO, ALEATORIZADO PARA EVALUAR LA EFICACIA Y LA SEGURIDAD DEL TRATAMIENTO PROLONGADO CON CAMIZESTRANT (AZD9833, UN DEGRADADOR SELECTIVO DEL RECEPTOR DE ESTR\u00d3GENOS ORAL Y DE NUEVA GENERACI\u00d3N) FRENTE AL TRATAMIENTO ENDOCRINO EST\u00c1NDAR (INHIBIDOR DE LA AROMATASA O TAMOXIFENO) EN PACIENTES CON C\u00c1NCER DE MAMA TEMPRANO ER+\/HER2- Y UN RIESGO INTERMEDIO O ALTO DE RECA\u00cdDA QUE HAN COMPLETADO TRATAMIENTO LOCORREGIONAL DEFINITIVO Y AL MENOS 2 A\u00d1OS DE TRATAMIENTO ENDOCRINO ADYUVANTE EST\u00c1NDAR SIN RECA\u00cdDA DE LA ENFERMEDAD<\/strong>. Budget: 62.320\u20ac. 2023- . PI: VETHENCOURT CASADO, ANDREA CAROLINA.<\/li>\n<li>21PSJ002. <strong>Estudio de biomarcadores de la actividad antitumoral del denosumab y su papel como modulador de la respuesta inmune en el c\u00e1ncer de mama precoz: IO-D-BIOMARK<\/strong>. Fundaci\u00f3n Grupo Espa\u00f1ol de Investigaci\u00f3n en Cancer de Mama (GEICAM). Budget: 42.000\u20ac. 2021-2024. PI: VETHENCOURT CASADO, ANDREA CAROLINA.<\/li>\n<li>2023-571-1. <strong>ROLE OF RANK IN MYELOID CELLS AND TUMOR DEVELOPMENT<\/strong>. Fundaci\u00f3 &#8220;LA CAIXA&#8221;. 2023- . PI: GONZALEZ SUAREZ, EVA.<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\">More Information<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<p>The group has received uninterrupted competitive funding from public and private bodies, both nationally and internationally, with a total of 17 grants. Funding agencies include the following: MINECO, ISCIII, AECC, Mutua Madrile\u00f1a Foundation, Marat\u00f3 de TV3, as well as the most prestigious international associations (Concern Foundation (USA), Susan G. Komen Foundation (USA)). It recently received an ERC Consolidator Grant from the European Union, awarded to Dr Gonz\u00e1lez Su\u00e1rez.<\/p>\n<p>The group has also signed contacts with the industry and coordinates initial-phase clinical trials.<\/p>\n<p>&nbsp;<\/p>\nReferencia: 682935<br \/>\nT\u00edtulo: PLEIO-RANK: Pleiotropic treatment of cancer: RANK inhibitors targeting cancer stem cells and immunity<br \/>\nFinanciador: ERC &#8211; H2020<br \/>\nAgradecimiento: European Research Council (ERC) under the European Union&#8217;s Horizon 2020 research and innovation program\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2019\/12\/foto1-300x212.jpg\" alt=\"\" width=\"300\" height=\"212\" \/><\/p>\nReferencia: SLT006\/17\/00122<br \/>\nTipo: &#8220;CONTRACTES D&#8217;INCORPORACI\u00d3 DE CIENT\u00cdFICS I TECN\u00d2LEGS ALS GRUPS DE RECERCA&#8221;<br \/>\nFinanciador: DEPARTAMENT DE SALUT<br \/>\nAgradecimiento: Departament de Salut de la Generalitat de Catalunya mitjan\u00e7ant l&#8217;Acci\u00f3 instrumental d&#8217;incorporaci\u00f3 (PERIS).\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2019\/12\/foto2-300x152.jpg\" alt=\"\" width=\"300\" height=\"152\" \/><\/p>\n<p>&nbsp;<\/p>\nReferencia: BES-2015-071675<br \/>\nTipo: &#8220;AYUDAS PARA CONTRATOS PREDOCTORALES PARA LA FORMACI\u00d3N DE DOCTORES 2015&#8221;<br \/>\nFinanciador: Ministerio de Ciencia, Innovaci\u00f3n y Universidades<br \/>\nAgradecimiento: Ministerio de Ciencia, Innovaci\u00f3n y Universidades, perteneciente a la Agencia Estatal de Investigaci\u00f3n (AEI). Cofinanciado por el Fondo Social Europeo. FSE invierte en tu futuro\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2019\/12\/foto3-300x225.jpg\" alt=\"\" width=\"300\" height=\"225\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2019\/12\/foto3.1-300x84.png\" alt=\"\" width=\"300\" height=\"84\" \/><\/p>\n<p>&nbsp;<\/p>\nReferencia: PRE2018-086522<br \/>\nTipo: &#8220;AYUDAS PARA CONTRATOS PREDOCTORALES PARA LA FORMACI\u00d3N DE DOCTORES 2018&#8221;<br \/>\nFinanciador: Ministerio de Ciencia, Innovaci\u00f3n y Universidades<br \/>\nAgradecimiento: Ministerio de Ciencia, Innovaci\u00f3n y Universidades, perteneciente a la Agencia Estatal de Investigaci\u00f3n (AEI). Cofinanciado por el Fondo Social Europeo. FSE invierte en tu futuro\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2019\/12\/foto3-300x225.jpg\" alt=\"\" width=\"300\" height=\"225\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2019\/12\/foto3.1-300x84.png\" alt=\"\" width=\"300\" height=\"84\" \/><\/p>\n<p>&nbsp;<\/p>\nReferencia: IJCI-2017-31564<br \/>\nTipo: &#8220;AYUDAS JUAN DE LA CIERVA &#8211; INCORPORACION 2017&#8221;<br \/>\nFinanciador: Ministerio de Ciencia, Innovaci\u00f3n y Universidades<br \/>\nAgradecimiento: Ministerio de Ciencia, Innovaci\u00f3n y Universidades, perteneciente a la Agencia Estatal de Investigaci\u00f3n (AEI).\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2019\/12\/foto3-300x225.jpg\" alt=\"\" width=\"300\" height=\"225\" \/><\/p>\nReferencia: FJCI-2017-31565<br \/>\nTipo: &#8220;AYUDAS JUAN DE LA CIERVA &#8211; FORMACION 2017&#8221;<br \/>\nFinanciador: Ministerio de Ciencia, Innovaci\u00f3n y Universidades<br \/>\nAgradecimiento: Ministerio de Ciencia, Innovaci\u00f3n y Universidades, perteneciente a la Agencia Estatal de Investigaci\u00f3n (AEI).<br \/>\n<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2019\/12\/foto3-300x225.jpg\" alt=\"\" width=\"300\" height=\"225\" \/>\nReferencia: IDEAS19093GONZ<br \/>\nT\u00edtulo: RANK, instead of RANKL, as a new therapeutic target in Triple Negative Breast Cancer<br \/>\nFinanciador: Fundaci\u00f3n Cient\u00edfica de la AECC<br \/>\nAgradecimiento: Fundaci\u00f3n Cient\u00edfica de la Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2019\/12\/foto4.jpg\" alt=\"\" width=\"280\" height=\"122\" \/><\/p>\nSAF2017-86117-R. New insights in RANK signaling pathway: from biology to treatment<br \/>\nPI: Gonz\u00e1lez-Su\u00e1rez, Eva<br \/>\nMinisterio de Ciencia, Innovaci\u00f3n y Universidades, perteneciente a la Agencia Estatal de Investigaci\u00f3n (AEI).\n<p>Cofinanciado por el Fondo Europeo de Desarrollo Regional. FEDER, una manera de hacer Europa. Promover el desarrollo tecnol\u00f3gico, la innovaci\u00f3n y una investigaci\u00f3n de calidad.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2019\/12\/foto3-300x225.jpg\" alt=\"\" width=\"300\" height=\"225\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2019\/12\/foto5-300x78.png\" alt=\"\" width=\"300\" height=\"78\" \/><\/p>\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2019\/10\/ginzalez-suarez-eva-150x150.jpg\" alt=\"Gonzalez Suarez, Eva\" itemprop=\"image\" title=\"ginzalez-suarez-eva\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tGonzalez Suarez, Eva\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:egsuarez@idibell.cat\" title=\"egsuarez@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tegsuarez@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tPrincipal investigators\n\t<\/h2>\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2019\/10\/ginzalez-suarez-eva-150x150.jpg\" alt=\"Gonzalez Suarez, Eva\" itemprop=\"image\" title=\"ginzalez-suarez-eva\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tGonzalez Suarez, Eva\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:egsuarez@idibell.cat\" title=\"egsuarez@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tegsuarez@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\tRELATED LINKS\n\t<\/h4>\n<h4>\n\t\t<a href=\"http:\/\/www.enbdc.org\/\" title=\"ENBDC\" target=\"_blank\" rel=\"noopener\">\n\t\tENBDC\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/EGlezSuarezlab\" title=\"@EGlezSuarezlab\" target=\"_blank\" rel=\"noopener\">\n\t\t@EGlezSuarezlab\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tTeam\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tGroup leaders\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tClinical researchers \t\t\t\t<\/a>\n\t\t\t\t\t\tGroup leaders\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Gonzalez Suarez, Eva<\/li>\n<\/ul>\n\t\t\t\t\t\tClinical researchers \n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Vethencourt Casado, Andrea Carolina<\/li>\n<\/ul>\n<h2>\n\t\tRelated news\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/23402\" content=\"Artificial intelligence helps take decisions about bone marrow transplant\" \/><meta itemprop=\"datePublished\" content=\"2023-12-21\" \/><meta itemprop=\"dateModified\" content=\"2023-12-21\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2023\/12\/NO116-Mussetti-Bone-Marrow-2_1.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"682\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2023\/12\/artificial-intelligence-helps-take-decisions-about-bone-marrow-transplant\/\" title=\"Artificial intelligence helps take decisions about bone marrow transplant\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2023\/12\/artificial-intelligence-helps-take-decisions-about-bone-marrow-transplant\/\" title=\"Artificial intelligence helps take decisions about bone marrow transplant\">Artificial intelligence helps take decisions about bone marrow transplant<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t21\/12\/2023\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/23222\" content=\"The \"la Caixa\" Foundation promotes a promising study against pancreatic cancer\" \/><meta itemprop=\"datePublished\" content=\"2023-11-24\" \/><meta itemprop=\"dateModified\" content=\"2023-11-24\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2023\/11\/Rovira-Espinet-scaled.jpg\" \/><meta itemprop=\"width\" content=\"2560\" \/><meta itemprop=\"height\" content=\"1280\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2023\/11\/the-la-caixa-foundation-promotes-a-promising-study-against-pancreatic-cancer\/\" title=\"The \"la Caixa\" Foundation promotes a promising study against pancreatic cancer\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2023\/11\/the-la-caixa-foundation-promotes-a-promising-study-against-pancreatic-cancer\/\" title=\"The \"la Caixa\" Foundation promotes a promising study against pancreatic cancer\">The &#8220;la Caixa&#8221; Foundation promotes a promising study against pancreatic cancer<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t24\/11\/2023\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/23392\" content=\"Researchers at CNIO and IDIBELL shed light on the role in lactation of a protein also crucial in breast cancer\" \/><meta itemprop=\"datePublished\" content=\"2023-10-09\" \/><meta itemprop=\"dateModified\" content=\"2023-12-19\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2023\/12\/investigadores-del-idibell.jpg\" \/><meta itemprop=\"width\" content=\"1200\" \/><meta itemprop=\"height\" content=\"675\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2023\/10\/researchers-at-cnio-and-idibell-shed-light-on-the-role-in-lactation-of-a-protein-also-crucial-in-breast-cancer\/\" title=\"Researchers at CNIO and IDIBELL shed light on the role in lactation of a protein also crucial in breast cancer\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2023\/10\/researchers-at-cnio-and-idibell-shed-light-on-the-role-in-lactation-of-a-protein-also-crucial-in-breast-cancer\/\" title=\"Researchers at CNIO and IDIBELL shed light on the role in lactation of a protein also crucial in breast cancer\">Researchers at CNIO and IDIBELL shed light on the role in lactation of a protein also crucial in breast cancer<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t09\/10\/2023\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/16814\" content=\"A connection between senescence and stem cells caused by a breast cancer-initiating protein\" \/><meta itemprop=\"datePublished\" content=\"2021-05-17\" \/><meta itemprop=\"dateModified\" content=\"2021-05-17\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2021\/05\/NP16-E-Gonzalez_Dev-Cell-Imatge.jpg\" \/><meta itemprop=\"width\" content=\"1418\" \/><meta itemprop=\"height\" content=\"1063\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2021\/05\/a-connection-between-senescence-and-stem-cells-caused-by-a-breast-cancer-initiating-protein\/\" title=\"A connection between senescence and stem cells caused by a breast cancer-initiating protein\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2021\/05\/a-connection-between-senescence-and-stem-cells-caused-by-a-breast-cancer-initiating-protein\/\" title=\"A connection between senescence and stem cells caused by a breast cancer-initiating protein\">A connection between senescence and stem cells caused by a breast cancer-initiating protein<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t17\/05\/2021\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/15817\" content=\"Xenograft Animal Models Recapitulate Genetic Behavior of Original Human Tumors\" \/><meta itemprop=\"datePublished\" content=\"2021-01-28\" \/><meta itemprop=\"dateModified\" content=\"2021-02-02\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2021\/01\/NO01-NatGen-Imatge.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2021\/01\/xenograft-animal-models-recapitulate-genetic-behavior-of-original-human-tumors\/\" title=\"Xenograft Animal Models Recapitulate Genetic Behavior of Original Human Tumors\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2021\/01\/xenograft-animal-models-recapitulate-genetic-behavior-of-original-human-tumors\/\" title=\"Xenograft Animal Models Recapitulate Genetic Behavior of Original Human Tumors\">Xenograft Animal Models Recapitulate Genetic Behavior of Original Human Tumors<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t28\/01\/2021\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/15588\" content=\"Scientists discover the immunomodulatory activity of a drug that would improve the efficacy of immunotherapy against breast cancer\" \/><meta itemprop=\"datePublished\" content=\"2020-12-10\" \/><meta itemprop=\"dateModified\" content=\"2020-12-10\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/12\/20201209_141133.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2020\/12\/scientists-discover-the-immunomodulatory-activity-of-a-drug-that-would-improve-the-efficacy-of-immunotherapy-against-breast-cancer\/\" title=\"Scientists discover the immunomodulatory activity of a drug that would improve the efficacy of immunotherapy against breast cancer\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2020\/12\/scientists-discover-the-immunomodulatory-activity-of-a-drug-that-would-improve-the-efficacy-of-immunotherapy-against-breast-cancer\/\" title=\"Scientists discover the immunomodulatory activity of a drug that would improve the efficacy of immunotherapy against breast cancer\">Scientists discover the immunomodulatory activity of a drug that would improve the efficacy of immunotherapy against breast cancer<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t10\/12\/2020\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/10754\" content=\"Common immune characteristics found in lung metastases to target future treatments\" \/><meta itemprop=\"datePublished\" content=\"2020-07-17\" \/><meta itemprop=\"dateModified\" content=\"2020-07-21\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/07\/PADO-foto-grup-scaled.jpg\" \/><meta itemprop=\"width\" content=\"2560\" \/><meta itemprop=\"height\" content=\"1920\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2020\/07\/common-immune-characteristics-found-in-lung-metastases-to-target-future-treatments\/\" title=\"Common immune characteristics found in lung metastases to target future treatments\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2020\/07\/common-immune-characteristics-found-in-lung-metastases-to-target-future-treatments\/\" title=\"Common immune characteristics found in lung metastases to target future treatments\">Common immune characteristics found in lung metastases to target future treatments<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t17\/07\/2020\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/5029\" content=\"David Llobet and Eva Gonz\u00e1lez Su\u00e1rez receive AECC grants on World Cancer Research Day\" \/><meta itemprop=\"datePublished\" content=\"2019-09-24\" \/><meta itemprop=\"dateModified\" content=\"2020-05-05\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/erigin\/\" \/><meta itemprop=\"name\" content=\"Idibell\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/05\/efou6jzxoaaohib-1.jpg\" \/><meta itemprop=\"width\" content=\"680\" \/><meta itemprop=\"height\" content=\"510\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2019\/09\/david-llobet-and-eva-gonzalez-suarez-receive-aecc-grants-on-world-cancer-research-day\/\" title=\"David Llobet and Eva Gonz\u00e1lez Su\u00e1rez receive AECC grants on World Cancer Research Day\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2019\/09\/david-llobet-and-eva-gonzalez-suarez-receive-aecc-grants-on-world-cancer-research-day\/\" title=\"David Llobet and Eva Gonz\u00e1lez Su\u00e1rez receive AECC grants on World Cancer Research Day\">David Llobet and Eva Gonz\u00e1lez Su\u00e1rez receive AECC grants on World Cancer Research Day<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/erigin\/\">Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t24\/09\/2019\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/5058\" content=\"Researchers from IDIBELL confirm the validity of xenographic models for studies of methylation and chemoresistance in breast cancer\" \/><meta itemprop=\"datePublished\" content=\"2019-07-18\" \/><meta itemprop=\"dateModified\" content=\"2020-05-15\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/erigin\/\" \/><meta itemprop=\"name\" content=\"Idibell\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/05\/heatmap_egs-1.jpg\" \/><meta itemprop=\"width\" content=\"1654\" \/><meta itemprop=\"height\" content=\"1384\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2019\/07\/researchers-from-idibell-confirm-the-validity-of-xenographic-models-for-studies-of-methylation-and-chemoresistance-in-breast-cancer\/\" title=\"Researchers from IDIBELL confirm the validity of xenographic models for studies of methylation and chemoresistance in breast cancer\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2019\/07\/researchers-from-idibell-confirm-the-validity-of-xenographic-models-for-studies-of-methylation-and-chemoresistance-in-breast-cancer\/\" title=\"Researchers from IDIBELL confirm the validity of xenographic models for studies of methylation and chemoresistance in breast cancer\">Researchers from IDIBELL confirm the validity of xenographic models for studies of methylation and chemoresistance in breast cancer<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/erigin\/\">Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t18\/07\/2019\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/5085\" content=\"IDIBELL researchers relate the amplification of a chromosomal region with resistance to a chemotherapeutic drug in breast cancer\" \/><meta itemprop=\"datePublished\" content=\"2019-06-18\" \/><meta itemprop=\"dateModified\" content=\"2020-05-15\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/erigin\/\" \/><meta itemprop=\"name\" content=\"Idibell\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/05\/jorge_gomez_miragaya_y_eva_gonzalez_suarez-1.jpg\" \/><meta itemprop=\"width\" content=\"556\" \/><meta itemprop=\"height\" content=\"515\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2019\/06\/idibell-researchers-relate-the-amplification-of-a-chromosomal-region-with-resistance-to-a-chemotherapeutic-drug-in-breast-cancer\/\" title=\"IDIBELL researchers relate the amplification of a chromosomal region with resistance to a chemotherapeutic drug in breast cancer\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2019\/06\/idibell-researchers-relate-the-amplification-of-a-chromosomal-region-with-resistance-to-a-chemotherapeutic-drug-in-breast-cancer\/\" title=\"IDIBELL researchers relate the amplification of a chromosomal region with resistance to a chemotherapeutic drug in breast cancer\">IDIBELL researchers relate the amplification of a chromosomal region with resistance to a chemotherapeutic drug in breast cancer<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/erigin\/\">Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t18\/06\/2019\t\t\t\t\t\t\t\n\t\t<!-- .pp-content-posts -->\n\n","protected":false},"excerpt":{"rendered":"<p>Transformation and metastasis Summary This group&#8217;s research aims to identify new therapeutic targets for cancer which can be directly translated into effective prevention or treatment strategies. Its aim is to understand the signalling pathways involved in the epithelial stem cell fate and homeostasis, their alterations during cancer and metastasis, and the interactions between tumour cells [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":448,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-2364","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2024-11-30 11:24:02","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/2364","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/comments?post=2364"}],"version-history":[{"count":8,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/2364\/revisions"}],"predecessor-version":[{"id":24323,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/2364\/revisions\/24323"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/448"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media?parent=2364"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}