{"id":2340,"date":"2019-10-05T18:50:35","date_gmt":"2019-10-05T16:50:35","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2340"},"modified":"2024-06-19T14:33:34","modified_gmt":"2024-06-19T12:33:34","slug":"ageing-and-cancer","status":"publish","type":"page","link":"https:\/\/idibell.cat\/en\/research\/cancer-area\/molecular-mechanisms-and-experimental-therapy-in-oncology-program-oncobell\/ageing-and-cancer\/","title":{"rendered":"Ageing and Cancer"},"content":{"rendered":"\n<h1>\n\t\tAgeing and cancer\n\t<\/h1>\n<h3>\n\t\tSummary\n\t<\/h3>\n\tThis group&#8217;s main objectives are to analyze mechanisms involved in cancer cell plasticity and the impact of this plasticity on skin SCC progression and therapy response. We are interested in determining the molecular mechanisms that promote cutaneous SCC (cSCC) progression and metastasis, by studying pathways that regulate cancer cell plasticity and cancer stem cell function, as well as in determining the impact of cancer cell plasticity on tumor microenvironment, but also how tumor microenvironment impacts on cancer cell plasticity, cSCC progression and therapy response. The final aim of these studies is to define the molecular basis for new therapeutic treatments that block cSCC recurrence and metastasis and overcome intrinsic and acquired resistance to therapy.<br \/>\nDr. Mu\u00f1oz&#8217;s laboratory has generated mouse models of cSCC (cSCC-PDXs, amongst others) that have been used as pre-clinical models to evaluate the anti-tumor efficiency of different drugs, and to study combined therapies to overcome primary and\/or acquired resistance to these drugs.<br \/>\nOur group is composed by translational and clinical researchers (surgeons and pathologist) from Bellvitge Hospital (HUB, partner of IDIBELL), and collaborates with Oncologists from ICO\/IDIBELL. This close interaction between basic and clinical researchers provides perspective on the critical questions associated with HNSCC and cSCC pathologies.\n<h2>156<\/h2>\n<h2>Publications<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/04\/606_munoz.jpg\" alt=\"606_munoz\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"606_munoz\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">Strategic lines<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\"><i>Expand<\/i><\/a>\n\t\t\t\t\t 1. To study mechanisms involved in the regulation of cancer cell plasticity during cSCC progression and to determine the relevance of tumor microenvironment-derived factors in promoting cancer cell plasticity and tumor progression.<br \/>\n2. To investigate the molecular basis of resistance to ICB therapy in HNSCC and cSCCs, but also to therapies based in EGFR inhibitors in HNSCCs.<br \/>\n3. To identify biomarkers that predict cSCC progression and resistance to ICB in HNSCC and cSCCs and resistance to EGFR inhibitors in HNSCCs.\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Selected Publications<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Drakaki,A;Powles,T;Bamias,A;Martin Liberal,J;Shin,SJ;Friedlander,T;Tosi,D et al, <strong>Atezolizumab plus Magrolimab, Niraparib, or Tocilizumab versus Atezolizumab Monotherapy in Platinum-Refractory Metastatic Urothelial Carcinoma: A Phase Ib\/II Open-Label, Multicenter, Randomized Umbrella Study (MORPHEUS Urothelial Carcinoma)<\/strong>., Clin. Cancer Res., 2023;29(21):4373-4384, doi:10.1158\/1078-0432.CCR-23-0798<\/li>\n<li>Soto Castillo,JJ;Llavata Marti,L;Fort Culillas,R;Andreu Cobo,P;Moreno,R;Codony,C;del Muro,XG et al, <strong>SWI\/SNF Complex Alterations in Tumors with Rhabdoid Features: Novel Therapeutic Approaches and Opportunities for Adoptive Cell Therapy<\/strong>, Int. J. Mol. Sci., 2023;24(13):doi:10.3390\/ijms241311143<\/li>\n<li>Creus Bachiller,E;Fern\u00e1ndez Rodr\u00edguez,J;Magall\u00f3n Lorenz,M;Ortega Bertran,S;Navas Rutete,S;Romagosa,C;Silva,TM et al, <strong>Expanding a precision medicine platform for malignant peripheral nerve sheath tumors: New patient-derived orthotopic xenografts, cell lines and tumor entities<\/strong>, Mol. Oncol., 2023;doi:10.1002\/1878-0261.13534<\/li>\n<li>Manzano,JL;Martin Liberal,J;Fernandez Morales,LA;Benitez,G;Martinez,JM;Quindos,M;Garcia Castano,A et al, <strong>Adjuvant dabrafenib and trametinib for patients with resected BRAF-mutated melanoma: DESCRIBE-AD real-world retrospective observational study<\/strong>, Melanoma Res., 2023;33(5):388-397, doi:10.1097\/CMR.0000000000000888<\/li>\n<li>Mill\u00e1n Esteban,D;Garc\u00eda Casado,Z;Maci\u00e0,A;de la Rosa,I;Torrecilla Llossera,C;Pen\u00edn,RM;Manrique Silva,E et al, <strong>Molecular Profile of Subungual Melanoma: a MelaNostrum Consortium Study of 68 Cases Reporting BRAF, NRAS, KIT, and TERT promoter status<\/strong>., Dermatology, 2023;240(1):164-169, doi:10.1159\/000534955<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Selected Projects<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>MCI21004. <strong>Estudio de nuevas estrategias terap\u00e9uticas para suprimir la resistencia a terapias basadas en el bloqueo de los puntos de control inmunitarios (ICB) en cSCC y HNSCCs avanzados<\/strong>. Ministerio de Ciencia e Innovaci\u00f3n. Budget: 223.850\u20ac. 2021-2024. PI: MU\u00d1OZ MORUNO, PURIFICACION.<\/li>\n<li>FIS21126. <strong>Tratamiento con TILs en tumores avanzados con alteraciones del complejo SWI\/SNF: El estudio TILTS<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 1.081.914,72\u20ac. 2022-2025. PI: MARTIN LIBERAL, JUAN JESUS.<\/li>\n<li>AGA22038. <strong>Nuevas terapias para el tratamiento de c\u00e1ncer de piel<\/strong><br \/>\n<strong>Novel therapies for skin cancer treatment<\/strong>. AGENCIA GESTIO D&#8217;AJUTS UNIV. I RECERCA. Budget: 40.000\u20ac. 2022-2025. PI: MU\u00d1OZ MORUNO, PURIFICACION; MARTIN LIBERAL, JUAN JESUS.<\/li>\n<li>PSJ22017. <strong>INFLUENCIA DE LA PLASTICIDAD DE LAS C\u00c9LULAS TUMORALES EN LA RESPUESTA AL TRATAMIENTO ADYUVANTE CON ANTI-PD-1 EN MELANOMA ESTAD\u00cdO IIIC\/D RESECADO<\/strong>. Grupo Espa\u00f1ol Multidisciplinar de Melanoma (GEM). Budget: 20.000\u20ac. 2022-2024. PI: MARTIN LIBERAL, JUAN JESUS; MU\u00d1OZ MORUNO, PURIFICACION.<\/li>\n<li>2023-020-1. <strong>Adjuvant encorafenib &amp; binimetinib vs. placebo in fully resected stage IIB\/C BRAF V600E\/K mutated melanoma: a randomized triple-blind phase III study in collaboration with the EORTC Melanoma Group<\/strong>. Pierre Fabre M\u00e9dicamen. Budget: 510.984\u20ac. 2022- . PI: MARTIN LIBERAL, JUAN JESUS.<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\">More Information<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<p><strong>Selected theses:<\/strong><\/p>\n<h3>Mecanismos moleculares que regulan el crecimiento, la met\u00e1stasis y la resistencia a terapias del carcinoma escamoso de piel<\/h3>\n<p>Mu\u00f1oz Moruno, Purificacion (Director)<\/p>\n<p>Phd Student:<\/p>\n<ul>\n<li>Adri\u00e0 Bernat Peguera<\/li>\n<\/ul>\n<p>2019, UB.<\/p>\n<hr \/>\n<h3>Estudio de los mecanismos moleculares que promueven la progresi\u00f3n del carcinoma escamoso de piel<\/h3>\n<p>Mu\u00f1oz Moruno, Purificacion (Director)<\/p>\n<p>Phd Student:<\/p>\n<ul>\n<li>Pilar Sim\u00f3n Extremera<\/li>\n<\/ul>\n<p>2017, UB.<\/p>\n<hr \/>\n<h3>Impact of cancer cell plasticity on tumor immune microenvironment and immunotherapy response<\/h3>\n<p>Mu\u00f1oz Moruno, Purificacion (Director)<\/p>\n<p>Phd Student:<\/p>\n<ul>\n<li>Laura Lorenzo Sanz<\/li>\n<\/ul>\n<p>2021, UB.<\/p>\n<hr \/>\n<h3>Theses in process:<\/h3>\n<p>Mu\u00f1oz Moruno, Purificacion (Director)<\/p>\n<p>Phd Students:<\/p>\n<ul>\n<li>Marta L\u00f3pez Cerda<\/li>\n<li>Joan Navarro Ventura<\/li>\n<li>Marta L\u00f3pez Cerda<\/li>\n<\/ul>\n<p>UB.<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/11\/Purificacion-Munoz-150x150.jpg\" alt=\"Purificacion-Mu\u00f1oz\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Purificacion-Mu\u00f1oz\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tMu\u00f1oz Moruno, Purificaci\u00f3n\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:p.munoz@idibell.cat\" title=\"p.munoz@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tp.munoz@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tInvestigadores principales\n\t<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/11\/Purificacion-Munoz-150x150.jpg\" alt=\"Purificacion-Mu\u00f1oz\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Purificacion-Mu\u00f1oz\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tMu\u00f1oz Moruno, Purificaci\u00f3n\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:p.munoz@idibell.cat\" title=\"p.munoz@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tp.munoz@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/11\/Joan-Vinals-Vinals-150x150.jpg\" alt=\"Joan-Vi\u00f1als-Vi\u00f1als\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Joan-Vi\u00f1als-Vi\u00f1als\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tVi\u00f1als Vi\u00f1als, Joan M.\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:jvinals@idibell.cat\" title=\"jvinals@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tjvinals@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2023\/04\/Juan-Martin-Liberal-150x150.jpg\" alt=\"Juan-Martin-Liberal\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Juan-Martin-Liberal\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tMartin Liberal, Juan Jes\u00fas\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:jmartinl@idibell.cat\" title=\"jmartinl@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tjmartinl@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\tRELATED LINKS\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/purimunnoz\" title=\"@purimunnoz\" target=\"_blank\" rel=\"noopener\">\n\t\t@purimunnoz\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tTeam\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tGroup leaders \t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPrincipal investigators\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tClinical researchers \t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPostdoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\tGroup leaders \n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Mu\u00f1oz Moruno, Purificaci\u00f3n<\/li>\n<\/ul>\n\t\t\t\t\t\tPrincipal investigators\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Vi\u00f1als Vi\u00f1als, Joan M.<\/li>\n<li>Martin Liberal, Juan Jes\u00fas<\/li>\n<\/ul>\n\t\t\t\t\t\tClinical researchers \n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Penin Mosquera, Rosa Maria<\/li>\n<li>Perez Sidelnikova, Diana<\/li>\n<\/ul>\n\t\t\t\t\t\tPostdoctoral researchers\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Lorenzo Sanz, Laura<\/li>\n<li>Lopez Cerda, Marta<\/li>\n<\/ul>\n<h2>\n\t\tRelated news\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/15817\" content=\"Xenograft Animal Models Recapitulate Genetic Behavior of Original Human Tumors\" \/><meta itemprop=\"datePublished\" content=\"2021-01-28\" \/><meta itemprop=\"dateModified\" content=\"2021-02-02\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" 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content=\"2018-07-04\" \/><meta itemprop=\"dateModified\" content=\"2020-05-05\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/erigin\/\" \/><meta itemprop=\"name\" content=\"Idibell\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2018\/07\/a-european-project-to-build-a-research-infrastructure-for-access-to-patient-derived-cancer-models-and-data-towards-advances-in-translational-oncology\/\" title=\"A European project to build a research infrastructure for access to patient-derived cancer models and data towards advances in translational oncology\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2018\/07\/a-european-project-to-build-a-research-infrastructure-for-access-to-patient-derived-cancer-models-and-data-towards-advances-in-translational-oncology\/\" title=\"A European project to build a research infrastructure for access to patient-derived cancer models and data towards advances in translational oncology\">A European project to build a research infrastructure for access to patient-derived cancer models and data towards advances in translational oncology<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/erigin\/\">Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t04\/07\/2018\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/5645\" content=\"Cancer stem cell regulation changes during skin carcinoma progression to promote metastasis\" \/><meta itemprop=\"datePublished\" content=\"2016-01-12\" \/><meta itemprop=\"dateModified\" content=\"2020-05-15\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/erigin\/\" \/><meta itemprop=\"name\" content=\"Idibell\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2016\/01\/cancer-stem-cell-regulation-changes-during-skin-carcinoma-progression-to-promote-metastasis\/\" title=\"Cancer stem cell regulation changes during skin carcinoma progression to promote metastasis\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2016\/01\/cancer-stem-cell-regulation-changes-during-skin-carcinoma-progression-to-promote-metastasis\/\" title=\"Cancer stem cell regulation changes during skin carcinoma progression to promote metastasis\">Cancer stem cell regulation changes during skin carcinoma progression to promote metastasis<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/erigin\/\">Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t12\/01\/2016\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/6564\" content=\"The epidermal stem cells contribute to the development of squamous cell carcinoma\" \/><meta itemprop=\"datePublished\" content=\"2012-10-16\" \/><meta itemprop=\"dateModified\" content=\"2022-03-23\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/erigin\/\" \/><meta itemprop=\"name\" content=\"Idibell\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2012\/10\/Puri-Munoz-1.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2012\/10\/the-epidermal-stem-cells-contribute-to-the-development-of-squamous-cell-carcinoma\/\" title=\"The epidermal stem cells contribute to the development of squamous cell carcinoma\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2012\/10\/the-epidermal-stem-cells-contribute-to-the-development-of-squamous-cell-carcinoma\/\" title=\"The epidermal stem cells contribute to the development of squamous cell carcinoma\">The epidermal stem cells contribute to the development of squamous cell carcinoma<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/erigin\/\">Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t16\/10\/2012\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/6644\" content=\"Six students will live the summer in IDIBELL\" \/><meta itemprop=\"datePublished\" content=\"2012-07-02\" \/><meta itemprop=\"dateModified\" content=\"2022-06-13\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/erigin\/\" \/><meta itemprop=\"name\" content=\"Idibell\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2012\/07\/estrella_mar_1-1.jpg\" \/><meta itemprop=\"width\" content=\"767\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2012\/07\/six-students-will-live-the-summer-in-idibell\/\" title=\"Six students will live the summer in IDIBELL\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2012\/07\/six-students-will-live-the-summer-in-idibell\/\" title=\"Six students will live the summer in IDIBELL\">Six students will live the summer in IDIBELL<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/erigin\/\">Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t02\/07\/2012\t\t\t\t\t\t\t\n\t\t<!-- .pp-content-posts -->\n\n","protected":false},"excerpt":{"rendered":"<p>Ageing and cancer Summary This group&#8217;s main objectives are to analyze mechanisms involved in cancer cell plasticity and the impact of this plasticity on skin SCC progression and therapy response. We are interested in determining the molecular mechanisms that promote cutaneous SCC (cSCC) progression and metastasis, by studying pathways that regulate cancer cell plasticity and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":448,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-2340","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2024-12-29 11:00:00","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/2340","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/comments?post=2340"}],"version-history":[{"count":7,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/2340\/revisions"}],"predecessor-version":[{"id":24322,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/2340\/revisions\/24322"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/448"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media?parent=2340"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}