{"id":2137,"date":"2019-10-02T00:58:47","date_gmt":"2019-10-01T22:58:47","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2137"},"modified":"2024-01-11T08:49:32","modified_gmt":"2024-01-11T07:49:32","slug":"cellular-and-molecular-basis-of-sensory-disorders","status":"publish","type":"page","link":"https:\/\/idibell.cat\/en\/research\/neuroscience-area\/neuroscience-program\/cellular-and-molecular-basis-of-sensory-disorders\/","title":{"rendered":"Cellular and molecular basis of sensory disorders"},"content":{"rendered":"\n

\n\t\tCellular and molecular basis of sensory disorders\n\t<\/h1>\n

\n\t\tSummary\n\t<\/h3>\n\t

The group undertakes the challenges of treating sensory disorders and preserving sensory functions during ageing, through the study of original animal models in the vestibular system and retina. The group develops models which enable it to obtain therapeutically relevant information on these highly complex sensory systems through the use of first-line methodologies, such as super-resolution fluorescence microscopy, RNA-seq and proteomics.<\/p>\n

149<\/h2>\n

Publications<\/h2>\n\t\t\t\t\"208-basescelmoltrastsensorials-jllorens-def\"\n\t\t\t\t\tStrategic lines<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\tStudy of cellular and molecular mechanisms of vestibular dysfunction using chronic toxicity models and in vitro models
\nRodent models to assess vestibular function
\nZebrafish models to study hair cell degeneration
\nCauses of vestibular loss in vestibular schwannoma patients
\nPhotoreceptor cell physiology
\nMolecular and cellular basis of light adaptation
\nPhosphoproteome of the dark\/light retina
\nRetinal metabolism
\nPolarized ciliary trafficking in photoreceptor cells
\nMouse models of inherited retinal dystrophies and testing of new therapeutic approaches\n\t\t\t\t\t
Selected Publications<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t

Barrallo Gimeno A, Llorens J. Hair cell toxicology: With the help of a little fish<\/strong>. Front. Cell. Dev. Biol. 2022;10doi:10.3389\/fcell.2022.1085225.<\/p>\n

Garg G, Finger PT, Kivel\u00e4 TT, Simpson ER, Gallie BL, Saakyan S, Amiryan AG, Valskiy V, Chin KJ, Semenova E, Seregard S, Fil\u00ec M, Wilson M, Haik B, Caminal JM, Catala Mora J, Guti\u00e9rrez C, Pelayes DE, Folgar AM, Jager MJ, Dogrus\u00f6z M, Luyten GPM, Singh AD, Suzuki S, AJCC Ophthalmic Oncology Task F. Patients presenting with metastases: stage IV uveal melanoma, an international study<\/strong>. Br J Ophthalmol. 2022;106(4):510-517. doi:10.1136\/bjophthalmol-2020-317949.<\/p>\n

Caminal JM, Lorenzo D, Gutierrez C, Slocker A, Piulats JM, Cobos E, Garcia Bru P, Morwani R, Santamaria JF, Arias L. Local Resection in Choroidal Melanoma: A Review<\/strong>. J. Clin. Med. 2022;11(23):doi:10.3390\/jcm11237156.<\/p>\n

Garcia Tornel A, Millan M, Rubiera M, Bustamante A, Requena M, Dorado L, Oliv\u00e9 Gadea M, Jim\u00e9nez X, Soto A, Querol M, Hern\u00e1ndez P\u00e9rez M, Gomis M, Cardona P, Urra X, Purroy F, Silva Y, Ustrell X, Esteve P, Salvat Plana M, Gallofr\u00e9 M, Molina C, D\u00e1valos A, Jovin T, Abilleira S, Ribo M, P\u00e9rez de la Ossa N, RACECAT Trial I. Workflows and Outcomes in Patients With Suspected Large Vessel Occlusion Stroke Triaged in Urban and Nonurban Areas<\/strong>. Stroke. 2022;doi:10.1161\/STROKEAHA.122.040768.<\/p>\n

Gabrielle PH, Nguyen V, Arnould L, Viola F, Zarranz Ventura J, Barthelmes D, Creuzot Garcher C, Gillies M, Fight Retinal Blindness! Study G. Incidence, Risk Factors, and Outcomes of Rhegmatogenous Retinal Detachment after Intravitreal Injections of Anti-VEGF for Retinal Diseases: Data from the Fight Retinal Blindness! Registry<\/strong>. Ophthalmol Retina. 2022;6(11):1044-1053. doi:10.1016\/j.oret.2022.05.008.<\/p>\n\t\t\t\t\tSelected Projects<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t

PUB22015. Aplicaci\u00f3 de noves tecnologies moleculars en el diagn\u00f2stic gen\u00e8tic de les distr\u00f2fies heredit\u00e0ries de retina<\/strong>. Hospital Universitario de Bellvitge. Budget: 20000. 2022-2025. PI: Cobos Mart\u00edn, Estefan\u00eda.<\/p>\n2022-222-1. RETROSPECTIVE CHART REVIEW STUDY COMBINED WITH CROSS-SECTIONAL PATIENT AND CAREGIVER SURVEYS TO DOCUMENT AND DESCRIBE THE DISEASE-RELATED CLINICAL, INDIVIDUAL, SOCIO-DEMOGRAPHIC CHARACTERISTICS OF PATIENTS WITH X-LINKED RETINITIS PIGMENTOSA (XLRP) AND THE IMPACT OF XLRP ON PATIENTS AND THEIR CAREGIVERS<\/strong>.
\n(EXPLORE XLRP 2 ). Budget: 7850. 2022- . PI: Cobos Mart\u00edn, Estefan\u00eda.\n

PCI2020-120681-2. Vestibular loss and spatial orientation<\/strong>. ERA-NET Neuron (Agencia Estatal de Investigaci\u00f3n). Budget: 150000. 2021-2024. PI: Llorens Baucells, Jordi.<\/p>\n

PID2021-124678OB-I00. New molecular mechanisms in chronic vestibular damage<\/strong>. Agencia Estatal de Investigaci\u00f3n. Budget: 96800. 2022-2025. PI: Llorens Baucells, Jordi i Barrallo Gimeno, Alejandro.<\/p>\n

PID2020-115431RB-I00. Retinal adaptation to light and pan-disease therapeutic targets in inherited blindness: IMPDH1 and energy metabolism<\/strong>. Agencia Estatal de Investigaci\u00f3n. Budget: 120000. 2021-2024. PI: M\u00e9ndez Zunzunegui, Ana.<\/p>\n

202007-30-31. A patient centered research: awareness of patient needs, clinical phenotyping and molecular parthenogenesis in Neurofibromatosis type 2<\/strong>. Fundaci\u00f3 La Marat\u00f3 de TV3. Budget: 142485,90. 2021-2024. PI: Llorens Baucells, Jordi.<\/p>\n\t\t\t\t\tMore Information<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\tIdentification of nitriles as a new family of compounds with vestibular toxicity.
\nBasic animal models for the ablation of capillary cells in the vestibular system of mice.
\nIdentification of synaptic decoupling and extrusion of capillary cells as the main events in chronic vestibular toxicity.
\nCharacterisation of the role of GCAP proteins in light responses.
\nIdentification of GCAP2 as a mediator of light damage, involved in the pathophysiology of “light” genetic disorders.\n\t\t\t\t\"Llorens\n

\n\t\tLlorens Baucells, Jordi\n\t<\/h4>\n

\n\t\t\n\t\tjllorens@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n

\n\t\tPrincipal investigators\n\t<\/h2>\n\t\t\t\t\"Llorens\n

\n\t\tLlorens Baucells, Jordi\n\t<\/h4>\n

\n\t\t\n\t\tjllorens@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\"mendez-zunzunegui-ana\"\n

\n\t\tMendez Zunzunegui, Ana\n\t<\/h4>\n

\n\t\t\n\t\tmendezzu@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\"Alejandro-Barrallo-Gimeno\"\n

\n\t\tBarrallo Gimeno, Alejandro\n\t<\/h4>\n

\n\t\t\n\t\tabarrallo@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\"Jaume-Catala-Mora\"\n

\n\t\tCatala Mora, Jaume \n\t<\/h4>\n

\n\t\tRELATED LINKS\n\t<\/h4>\n

\n\t\t\n\t\tInstitute of Neurosciences UB\n\t\t<\/a>\n\t<\/h4>\n

\n\t\t\n\t\t@UBneuroscience\n\t\t<\/a>\n\t<\/h4>\n

\n\t\t\n\t\t@JordiLlorensUB\n\t\t<\/a>\n\t<\/h4>\n

\n\t\t\n\t\t@alexbarrallo\n\t\t<\/a>\n\t<\/h4>\n

\n\t\tTeam\n\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\tGroup Leaders\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPrincipal Investigators\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tClinical investigators\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPostdoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPredoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\tGroup Leaders\n\t\t\t\t\t\t\t\t\t\t\t