{"id":20501,"date":"2022-05-04T12:11:07","date_gmt":"2022-05-04T10:11:07","guid":{"rendered":"https:\/\/idibell.cat\/en\/?page_id=20501"},"modified":"2024-01-29T09:19:09","modified_gmt":"2024-01-29T08:19:09","slug":"embryonic-cell-bioimaging","status":"publish","type":"page","link":"https:\/\/idibell.cat\/en\/research\/area-medicina-regenerativa-english\/regenerative-medicine-program\/embryonic-cell-bioimaging\/","title":{"rendered":"Embryonic Cell Bioimaging"},"content":{"rendered":"\n

\n\t\tEmbryonic Cell Bioimaging\n\t<\/h1>\n

\n\t\tSummary\n\t<\/h3>\n\t

Embryo development involves finely regulated cellular behaviors that coordinate the acquisition of cell fate with morphogenetic movements. Our lab studies embryonic dynamics across scales from molecular pathways to cell behaviour and collective cell-tissue interactions in their natural environment. We use a quantitative microscopy approach to perform live imaging of zebrafish, mouse, and human embryos and embryoids. We evaluate how the embryo solves the frequent anomalies found at early stages and self-repair to progress in development. We are interested in the protective, regenerative, and immune abilities of embryonic epithelial tissues. Studying dynamics and mechanics of embryonic phagocytosis, we aim to discover new paths to improve human fertility and regeneration of differentiated tissues. Our goal is to understand how stem cells start acting collectively to establish the minimum requirements for organ formation, including the capacity to restore homeostasis after damage.<\/p>\n

12<\/h2>\n

Publications<\/h2>\n\t\t\t\t\"Embryonic-Cell-Bioimaging2\"\n\t\t\t\t\tStrategic lines<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\tError correction and restoration of homeostasis in the early embryo
\nMechanics of epithelial phagocytosis in live embryos
\nEpithelial phagocytosis during regeneration of differentiated tissues\n\t\t\t\t\tSelected publications<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t2021 Esteban Hoijman*, Hanna Hakkinen, Queralt Tolosa, Senda Jim\u00e9nez-Delgado, Chris Wyatt, Marta Miret Cuesta, Manuel Irimia, Andrew Callan-Jones, Stefan Wieser* and Verena Ruprecht*.
\nCooperative epithelial phagocytosis enables early embryonic error correction.<\/strong>
\nNature, 590:618-623. *Corresponding author.\n
\n2017 Esteban Hoijman*, Laura Fargas, Patrick Blader and Berta Alsina*.
\nPioneer neurog1 expressing cells ingress in the otic primordium and instruct neural specification.<\/strong>
\neLife, 24;6. pii: e25543. *Corresponding author.\n
\n2015 Esteban Hoijman*, Davide Rubbini, Julien Colombelli and Berta Alsina*.
\nMitotic cell rounding and epithelial thinning regulate lumen growth and shape.<\/strong>
\nNature Communications, 6:7355. *Corresponding author.\n\t\t\t\t\tSelected Projects<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t

\nAnalysis across scales of epithelial protection in early embryogenesis: immunity before immune cell differentiation (Embryoimmun)
\n<\/h3>\n

Esteban Hoijman (Principal investigator (PI))<\/p>\n

Funder:<\/p>\n