{"id":1906,"date":"2019-09-26T18:29:17","date_gmt":"2019-09-26T16:29:17","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=1906"},"modified":"2024-06-19T14:22:38","modified_gmt":"2024-06-19T12:22:38","slug":"head-and-neck-diseases","status":"publish","type":"page","link":"https:\/\/idibell.cat\/en\/research\/cancer-area\/molecular-mechanisms-and-experimental-therapy-in-oncology-program-oncobell\/head-and-neck-diseases\/","title":{"rendered":"Head and neck diseases"},"content":{"rendered":"\n<h1>\n\t\tHead and neck diseases\n\t<\/h1>\n<h3>\n\t\tSummary\n\t<\/h3>\n\t<p>The Head and neck research group, as part of its line of cancer research, studies new therapeutic targets and predictive biomarkers of response to chemotherapy, radiotherapy and immunotherapy, the role of the human papilloma virus (HPV) and the differential management of HPV+ tumours, transoral treatment of laryngeal cancer with CO2 laser and robotic surgery, reconstructive surgery and pharyngeal rehabilitation of laryngectomised patients<\/p>\n<h2>406<\/h2>\n<h2>Publications<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/04\/511-malaltiescapcoll-mmanos-def.jpg\" alt=\"511-malaltiescapcoll-mmanos-def\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"511-malaltiescapcoll-mmanos-def\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">Strategic lines<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Recurrent respiratory papillomatosis. etiologic, clinic and treatment aspects, vaccine effects on the evolution and control of this desease.<\/li>\n<li>The new era of ear surgery : endoscopic ear surgery, safe techniques and results.<\/li>\n<li>Impacts of body composition in head and neck cancer<\/li>\n<li>New techniques for the surgical management of hereditary hemorragic telangiectasia (rendu-osler-weber disease)<\/li>\n<li>The effects of biologic treatments in chronic rhinosinusitis with polyposis.<\/li>\n<li>Radiomics and head and neck tumors<\/li>\n<li>The implementation of artificial intelligence in the diagnosis and management of head and neck tumors<\/li>\n<li>CT evaluation of sinonasal anatomy to improve the results and safeness of functional endoscopic sinonasal surgery<\/li>\n<li>Robotic surgery implementation and results in head and nceck cancer<\/li>\n<li>HPV and head and neck cancer<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Selected Publications<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Spreaflco,A;Heirali,AA;Araujo,DV;Tan,TJ;Oliva,M;Schneeberger,PHH;Chen,B et al, <strong>First-in-class Microbial Ecosystem Therapeutic 4 (MET4) in combination with immune checkpoint inhibitors in patients with advanced solid tumors (MET4-IO trial)<\/strong>, Ann. Oncol., 2023;34(6):520-530, doi:10.1016\/j.annonc.2023.02.011<\/li>\n<li>Mosteiro,M;Azuara,D;Villatoro,S;Alay,A;Gausachs,M;Varela,M;Baixeras,N et al, <strong>Molecular profiling and feasibility using a comprehensive hybrid capture panel on a consecutive series of non-small-cell lung cancer patients from a single centre<\/strong>, ESMO Open, 2023;8(6):doi:10.1016\/j.esmoop.2023.102197<\/li>\n<li>Hijazo Pechero,S;Alay,A;Cordero,D;Marin,R;Vilari\u00f1o,N;Palmero,R;Brenes,J et al, <strong>Transcriptional analysis of landmark molecular pathways in lung adenocarcinoma results in a clinically relevant classification with potential therapeutic implications<\/strong>, Mol. Oncol., 2023;18(2):453-470, doi:10.1002\/1878-0261.13550<\/li>\n<li>Naval Baudin,P;Pons Escoda,A;Camins,\u00c0;Arroyo,P;Viveros,M;Castell,J;Cos,M et al, <strong>Deeply 3D-T1-TFE hypointense voxels are characteristic of phase-rim lesions in multiple sclerosis<\/strong>., Eur. Radiol., 2023;34(2):1337-1345, doi:10.1007\/s00330-023-09784-w<\/li>\n<li>Maj\u00f3s,C;Pons Escoda,A;Naval,P;Guell,A;Lucas,A;Vidal,N;Cos,M et al, <strong>Proton MR spectroscopy shows improved performance to segregate high-grade astrocytoma subgroups when defined with the new 2021 World Health Organization classification of central nervous system tumors<\/strong>, Eur. Radiol., 2023;doi:10.1007\/s00330-023-10138-9<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Selected Projects<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>19ACL261. <strong>ESTUDIO CL\u00cdNICO DE FASE 3, ALEATORIZADO, DOBLE CIEGO Y CONTROLADO CON PLACEBO DE PEMBROLIZUMAB (MK-3475) CON O SIN LENVATINIB (E7080\/MK-7902) PARA EVALUAR LA SEGURIDAD Y LA EFICACIA DE PEMBROLIZUMAB Y LENVATINIB COMO INTERVENCI\u00d3N DE PRIMERA L\u00cdNEA EN UNA P<\/strong>. MERCK SHARP &amp; DOHME ESPA\u00d1A S.A.. Budget: 313.548\u20ac. 2019- . PI: OLIVA BERNAL, MARC.<\/li>\n<li>20ACL093. <strong>A RANDOMIZED, DOUBLE-BLIND, ADAPTIVE, PHASE II\/III STUDY OF GSK3359609 OR PLACEBO IN COMBINATION WITH PEMBROLIZUMAB FOR FIRST-LINE TREATMENT OF PD-L1 POSITIVE RECURRENT\/METASTATIC HEAD AND NECK SQUAMOUS CELL CARCINOMA<\/strong>. GlaxoSmithKline Research &amp; Development Limited;GlaxoSmithKline, S.A. Budget: 236.335,84\u20ac. 2020- . PI: Plana Serrahima, Mar\u00eda.<\/li>\n<li>2023-491-1. <strong>PHASE 1-2 STUDY INVESTIGATING SAFETY, TOLERABILITY, PHARMACOKINETICS AND PRELIMINARY ANTITUMOR ACTIVITY OF ANTI-TIM-3 MONOCLONAL ANTIBODY BGB-A425 IN COMBINATION WITH ANTI-PD-1 MONOCLONAL ANTIBODY TISLELIZUMAB IN PATIENTS WITH ADVANCED SOLID TUMORS<\/strong>. BEIGENE SWITZERLAND GMBH. Budget: 233.370\u20ac. 2023- . PI: OLIVA BERNAL, MARC.<\/li>\n<li>20ACL112. <strong>Estudio cl\u00ednico de fase 2, aleatorizado, abierto y de tres grupos para evaluar la seguridad y la eficacia de lenvatinib (E7080\/MK-7902) en combinaci\u00f3n con pembrolizumab (MK-3475) frente a la quimioterapia de referencia y lenvatinib en monoterapia en parti<\/strong>. MERCK SHARP &amp; DOHME ESPA\u00d1A S.A.. Budget: 215.055\u20ac. 2020- . PI: Taberna Sanz, Miren.<\/li>\n<li>2023-351-1. <strong>ENSAYO DE FASE I, ABIERTO, DE ESCALADO DE DOSIS DE BI 1831169 EN MONOTERAPIA Y EN COMBINACI\u00d3N CON EZABENLIMAB EN PACIENTES CON TUMORES S\u00d3LIDOS AVANZADOS O METAST\u00c1SICOS<\/strong>. Boehringer Ingelheim Espa\u00f1a, S.A.. Budget: 201.126\u20ac. 2023- . PI: OLIVA BERNAL, MARC.<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\">More Information<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<p><strong>Other Research Lines: <\/strong>The role of HPV on benign nasal disorders; TC evaluation of nasosinusal anatomy and its surgical implications; Genetic disorder and surgical treatment for patients with Rendu Osler Weber disease; Impact of body composition in head and neck cancer oncospecific treatments.<\/p>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/04\/Manel-Ma\u00f1os-150x150.jpg\" alt=\"Manel Ma\u00f1os\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Manel Ma\u00f1os\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tMa\u00f1os Pujol, Manel\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:mmanos@idibell.cat\" title=\"mmanos@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tmmanos@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tPrincipal investigators\n\t<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/04\/Manel-Ma\u00f1os-150x150.jpg\" alt=\"Manel Ma\u00f1os\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Manel Ma\u00f1os\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tMa\u00f1os Pujol, Manel\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:mmanos@idibell.cat\" title=\"mmanos@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tmmanos@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2021\/06\/Marc-Oliva-Bernal-150x150.jpg\" alt=\"Marc-Oliva-Bernal\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Marc-Oliva-Bernal\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tOliva Bernal, Marc\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:moliva@idibell.cat\" title=\"moliva@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tmoliva@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2021\/06\/Lorena-Arribas-Hortiguela.jpg\" alt=\"Lorena-Arribas-Hortig\u00fcela\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Lorena-Arribas-Hortig\u00fcela\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tArribas Hortig\u00fcela, Lorena\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:larribas@idibell.cat\" title=\"larribas@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tlarribas@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\tRELATED LINKS\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/OlivaM_Onc\" title=\"@OlivaM_Onc\" target=\"_blank\" rel=\"noopener\">\n\t\t@OlivaM_Onc\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tTeam\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tGroup leaders \t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPrincipal investigators \t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tClinical researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tScientific support\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-4\" data-index=\"4\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-4\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tCollaborators\t\t\t\t<\/a>\n\t\t\t\t\t\tGroup leaders \n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Ma\u00f1os Pujol, Manel<\/li>\n<\/ul>\n\t\t\t\t\t\tPrincipal investigators \n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Oliva Bernal, Marc<\/li>\n<li>Arribas Hortig\u00fcela, Lorena<\/li>\n<\/ul>\n\t\t\t\t\t\tClinical researchers\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Handam Zavarce, Miriam<\/li>\n<li>Nogues Orp\u00ed, Julio<\/li>\n<li>Cisa Lluis, Enric<\/li>\n<li>Melero Luque, Mireia<\/li>\n<li>Bermejo Sergu, Oriol<\/li>\n<li>Tornero Salto, Jordi<\/li>\n<li>Goma Gallego, Montserrat<\/li>\n<li>Cruellas Taischik, Francesc<\/li>\n<li>Gonzalez Compta, Xavier<\/li>\n<li>Mari Roig, Antoni<\/li>\n<li>Lozano Borbalas, Alicia<\/li>\n<li>Plana Serrahima, Maria<\/li>\n<li>Cos Domingo, Monica<\/li>\n<li>Rodriguez Bel, Laura<\/li>\n<li>Arranz Obispo, Carlos<\/li>\n<li>Brenes Castro, Jesus<\/li>\n<li>Penella Prat, Anna<\/li>\n<li>Brunet Garcia, Aina<\/li>\n<li>Bartel Arensburg, Ricardo<\/li>\n<li>Mesalles Ruiz, Marta<\/li>\n<li>Portillo Medina, Alex<\/li>\n<li>Morla, Arnaud Gerard<\/li>\n<li>Cusc\u00f3 Albors, Silvia<\/li>\n<li>Fulla Camp\u00ed, Marta<\/li>\n<li>Lares Archer, Henri R<\/li>\n<\/ul>\n\t\t\t\t\t\tScientific support\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Sospedra Martinez, Maria<\/li>\n<\/ul>\n\t\t\t\t\t\tCollaborators\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Rovira Casas, Aleix<\/li>\n<\/ul>\n<h2>\n\t\tRelated news\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/4900\" content=\"IDIBELL holds the Kickoff Meeting AES 2019 Health Research Projects funded by the ISCIII\" \/><meta itemprop=\"datePublished\" content=\"2020-03-03\" \/><meta itemprop=\"dateModified\" content=\"2022-12-20\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/erigin\/\" \/><meta itemprop=\"name\" content=\"Idibell\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/05\/foto_grup-1.jpg\" \/><meta itemprop=\"width\" content=\"1560\" \/><meta itemprop=\"height\" content=\"1017\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2020\/03\/idibell-holds-the-kickoff-meeting-aes-2019-health-research-projects-funded-by-the-isciii\/\" title=\"IDIBELL holds the Kickoff Meeting AES 2019 Health Research Projects funded by the ISCIII\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2020\/03\/idibell-holds-the-kickoff-meeting-aes-2019-health-research-projects-funded-by-the-isciii\/\" title=\"IDIBELL holds the Kickoff Meeting AES 2019 Health Research Projects funded by the ISCIII\">IDIBELL holds the Kickoff Meeting AES 2019 Health Research Projects funded by the ISCIII<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/erigin\/\">Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t03\/03\/2020\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/4977\" content=\"The researcher Purificaci\u00f3n Mu\u00f1oz receives the V Mart\u00ed Via prize\" \/><meta itemprop=\"datePublished\" content=\"2019-11-29\" \/><meta itemprop=\"dateModified\" content=\"2021-07-28\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/erigin\/\" \/><meta itemprop=\"name\" content=\"Idibell\" \/><meta itemprop=\"url\" 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itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2012\/03\/the-loss-of-a-protein-makes-jump-the-tumor-to-the-lymph-node\/\" title=\"The loss of a protein makes 'jump' the tumor to the lymph node\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2012\/03\/the-loss-of-a-protein-makes-jump-the-tumor-to-the-lymph-node\/\" title=\"The loss of a protein makes 'jump' the tumor to the lymph node\">The loss of a protein makes &#8216;jump&#8217; the tumor to the lymph node<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/erigin\/\">Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t06\/03\/2012\t\t\t\t\t\t\t\n\t\t<!-- .pp-content-posts -->\n\n","protected":false},"excerpt":{"rendered":"<p>Head and neck diseases Summary The Head and neck research group, as part of its line of cancer research, studies new therapeutic targets and predictive biomarkers of response to chemotherapy, radiotherapy and immunotherapy, the role of the human papilloma virus (HPV) and the differential management of HPV+ tumours, transoral treatment of laryngeal cancer with CO2 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":448,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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