Publications<\/h2>\n\t\t\t\t![\"metabolism-and-cancer3\"](\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/07\/metabolism-and-cancer3-1.png\" "\\"metabolism-and-cancer3\\"")
\n\t\t\t\t\tStrategic lines<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t\n- Ribosome Biogenesis and Biomass production in tumors – Antonio Gentilella<\/li>\n
- Metabolic Resistance of Tumors: Unraveling Metabolic Vulnerabilities – Antonio Gentilella<\/li>\n
- Translational reprogramming in oncogenic transformation – Antonio Gentilella<\/li>\n
- Cancer Stem Cells and Translational Control – Joffrey Pelletier<\/li>\n
- The “Ribo-inflamome” and the Differentiation Plasticity – Joffrey Pelletier<\/li>\n<\/ul>\n\t\t\t\t\tSelected Publications<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t
Lluch A, Veiga SR, Latorre J, Moreno Navarrete JM, Bonifaci N, Nguyen VD, Zhou Y, Horing M, Liebisch G, Olkkonen VM, Llobet Navas D, Thomas G, Rodriguez Barrueco R, Fern\u00e1ndez Real JM, Kozma SC, Ortega FJ. A compound directed against S6K1 hampers fat mass expansion and mitigates diet-induced hepatosteatosis<\/strong>. JCI Insight. 2022;7(14):doi:10.1172\/jci.insight.150461.<\/p>\nAlmacellas E, Garcia Cajide M, Tauler A, Mauvezin C. Analysis of Autophagic Vesicles in Mitotic Cells<\/strong>. Methods Mol Biol. 2022;2445127-137. doi:10.1007\/978-1-0716-2071-7_9.<\/p>\nPons C, Almacellas E, Tauler A, Mauvezin C. Detection of Nuclear Biomarkers for Chromosomal Instability<\/strong>. Methods Mol Biol. 2022;2445117-125. doi:10.1007\/978-1-0716-2071-7_8.<\/p>\nDomostegui A, Peddigari S, Mercer CA, Iannizzotto F, Rodriguez ML, Garcia Cajide M, Amador V, Diepstraten ST, Kelly GL, Salazar R, Kozma SC, Kusnadi EP, Kang J, Gentilella A, Pearson RB, Thomas G, Pelletier J.
\nImpaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death<\/strong>. Blood. 2021;137(24):3351-3364. doi:10.1182\/blood.2020007452.\nAlmacellas E, Pelletier J, Day C, Ambrosio S, Tauler A, Mauvezin C. Lysosomal degradation ensures accurate chromosomal segregation to prevent chromosomal instability<\/strong>. Autophagy. 2021;17(3):796-813. doi:10.1080\/15548627.2020.1764727.<\/p>\n <\/p>\n
<\/p>\n\n\t\t\t\t\tSelected Projects<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t\n- AEC21004. Overcoming resistance to therapy in Colorectal Cancer by attacking the 40S-LARP1-5’TOPs anabolic reservoir<\/strong>. Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer (AECC). Budget: 165.000\u20ac. 2021-2026. PI: Gentilella, Antonio, Pedro Fuentes .<\/li>\n
- 20PSJ024. Overcoming resistance to therapy in Colorectal Cancer by attacking the 40S-LARP1-5’TOPs anabolic reservoir<\/strong>. Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer (AECC). Budget: 150.000\u20ac. 2020-2025. PI: Gentilella, Antonio.<\/li>\n
- 19MEC009. AYUDAS PARA CONTRATOS PREDOCTORALES PARA LA FORMACI\u00d3N DE DOCTORES 2018<\/strong>. Ministerio de Ciencia e Innovaci\u00f3n. Budget: 88.250\u20ac. 2019-2023. PI: Gentilella, Antonio.<\/li>\n
- PID2021-122125NB-I00. Role of the 40S-LARP1 complex for the maintenance of tumor anabolic potential in colorectal cancer<\/strong>. Ministerio de Ciencie y Innovacion. Budget: 256.000\u20ac. 2022-2025. PI: Antonio Gentilella.<\/li>\n
- PID2022-141127OA-I00. Bloqueo de la biog\u00e9nesis ribisomal y la inflamaci\u00f3n celular aut\u00f3noma como nueva terapia de diferenciaci\u00f3n en el c\u00e1ncer colorectal<\/strong>. Ministerio de Ciencia e Innovaci\u00f3n . Budget: 260.000\u20ac. 2023-2026. PI: Joffrey Pelletier.<\/li>\n<\/ul>\n\t\t\t\t\tMore Information<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t
Dr Thomas and Dr Kozma are renowned for their discoveries related to the mTORC1\/S6K1\/4E-BP1 signalling pathway, having obtained FDA approval for the use of rapamycin in different types of cancer and to launch clinical trials based on the use of specific mTOR dual inhibitors.<\/p>\n
Dr Tauler has worked extensively on the glycolytic pathway and its control through mitogenic signals. Some of his studies on PF2K bifunctionality are included in leading Biochemistry textbooks<\/p>\n\t\t\t\t![\"Thomas,](\"https:\/\/idibell.cat\/wp-content\/uploads\/2019\/09\/thomas-george-150x150.jpg\" "\\"thomas-george\\"")
\n
\n\t\tThomas, George\n\t<\/h4>\n\n\t\t\n\t\tgthomas@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\n\t\tPrincipal investigators\n\t<\/h2>\n\t\t\t\t\n\n\t\tThomas, George\n\t<\/h4>\n\n\t\t\n\t\tgthomas@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t![\"Antonio-Gentilella-q\"](\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/07\/Antonio-Gentilella-q-150x150.jpg\" "\\"Antonio-Gentilella-q\\"")
\n\n\t\tGentilella, Antonio\n\t<\/h4>\n\n\t\t\n\t\tagentilella@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t![\"tauler-girona-albert\"](\"https:\/\/idibell.cat\/wp-content\/uploads\/2019\/09\/tauler-girona-albert-150x150.jpg\" "\\"tauler-girona-albert\\"")
\n\n\t\tTauler Girona, Albert\n\t<\/h4>\n\n\t\t\n\t\tatauler@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t![\"Joffrey-Pelletier\"](\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2023\/06\/Joffrey-Pelletier-150x150.jpg\" "\\"Joffrey-Pelletier\\"")
\n\n\t\tPelletier, Joffrey\n\t<\/h4>\n\n\t\t\n\t\tjpelletier@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\n\t\tRELATED LINKS\n\t<\/h4>\n\n\t\t\n\t\t@A_Gentilella\n\t\t<\/a>\n\t<\/h4>\n\n\t\tTeam\n\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\tGroup leaders \t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPrincipal investigators\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPostdoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPredoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tScientific support\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tStudents\t\t\t\t<\/a>\n\t\t\t\t\t\tGroup leaders \n\t\t\t\t\t\t\t\t\t\t\t\n- Thomas, George<\/li>\n<\/ul>\n\t\t\t\t\t\tPrincipal investigators\n\t\t\t\t\t\t\t\t\t\t\t
\n- Tauler Girona, Albert<\/li>\n
- Gentilella, Antonio<\/li>\n
- Pelletier, Joffrey<\/li>\n<\/ul>\n\t\t\t\t\t\tPostdoctoral researchers\n\t\t\t\t\t\t\t\t\t\t\t
\n- Fuentes Varela, Pedro<\/li>\n
- Iannizzotto , Flavia<\/li>\n<\/ul>\n\t\t\t\t\t\tPredoctoral researchers\n\t\t\t\t\t\t\t\t\t\t\t
\n- Mart\u00ednez Herr\u00e1ez, Carolina<\/li>\n
- Toccaceli, Alessia<\/li>\n<\/ul>\n\t\t\t\t\t\tScientific support\n\t\t\t\t\t\t\t\t\t\t\t
\n- Bosch Crespo, Pau<\/li>\n<\/ul>\n\t\t\t\t\t\tStudents\n\t\t\t\t\t\t\t\t\t\t\t
\n- Battaglia, Elisa<\/li>\n<\/ul>\n
\n\t\tRelated news\n\t<\/h2>\n\t\t\n\t\t\t\t<\/a>\n\t\t\tA study of IDIBELL and IDIBGI evaluates the efficacy of an anti-tumour drug against obesity<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t01\/08\/2022\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIn adverse conditions, tumor cells create ribosome reservoirs that allow them to survive<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t29\/11\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIDIBELL receives more than one and a half million euros from AECC to fund cancer research projects<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t17\/11\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tA new study deciphers the mechanisms involved in antitumor activity after inhibition of ribosome synthesis<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t09\/02\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tThe study of lysosomal function during cell division enables the identification of a new biomarker for chromosomal instability<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t07\/07\/2020\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tRibosome biogenesis senses nucleotide levels to preserve DNA integrity<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t23\/06\/2020\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tAn IDIBELL and UB research team demonstrates the involvement of glucose in the growth of tumor cells<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t04\/12\/2019\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tNew combined treatment shows promise in Hepatocellular Carcinoma<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t27\/06\/2018\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tA new ribosomal biogenesis regulation point to treat cancer and 5q- syndrome<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t29\/06\/2017\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tA Nature study reinforces the contribution of S6K1 kinase in obesity and aging<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t08\/02\/2017\t\t\t\t\t\t\t\n\t\t\n\n","protected":false},"excerpt":{"rendered":"Metabolism and cancer Summary The Metabolism and Cancer group includes Doctors George Thomas, Sara Kozma, Albert Tauler and Antonio Gentilella. The program focuses on the kinase signalling of the mammalian target of rapamycin complex 1 (mTORC1) and its main metabolic cascade responses, including ribosome biogenesis, control of translation, metabolic reprogramming, autophagy, lysosomal transport and cell […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":448,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-1865","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2024-11-19 21:11:36","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/1865"}],"collection":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/comments?post=1865"}],"version-history":[{"count":12,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/1865\/revisions"}],"predecessor-version":[{"id":24621,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/1865\/revisions\/24621"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/448"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media?parent=1865"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Lluch A, Veiga SR, Latorre J, Moreno Navarrete JM, Bonifaci N, Nguyen VD, Zhou Y, Horing M, Liebisch G, Olkkonen VM, Llobet Navas D, Thomas G, Rodriguez Barrueco R, Fern\u00e1ndez Real JM, Kozma SC, Ortega FJ. A compound directed against S6K1 hampers fat mass expansion and mitigates diet-induced hepatosteatosis<\/strong>. JCI Insight. 2022;7(14):doi:10.1172\/jci.insight.150461.<\/p>\n Almacellas E, Garcia Cajide M, Tauler A, Mauvezin C. Analysis of Autophagic Vesicles in Mitotic Cells<\/strong>. Methods Mol Biol. 2022;2445127-137. doi:10.1007\/978-1-0716-2071-7_9.<\/p>\n Pons C, Almacellas E, Tauler A, Mauvezin C. Detection of Nuclear Biomarkers for Chromosomal Instability<\/strong>. Methods Mol Biol. 2022;2445117-125. doi:10.1007\/978-1-0716-2071-7_8.<\/p>\nDomostegui A, Peddigari S, Mercer CA, Iannizzotto F, Rodriguez ML, Garcia Cajide M, Amador V, Diepstraten ST, Kelly GL, Salazar R, Kozma SC, Kusnadi EP, Kang J, Gentilella A, Pearson RB, Thomas G, Pelletier J. Almacellas E, Pelletier J, Day C, Ambrosio S, Tauler A, Mauvezin C. Lysosomal degradation ensures accurate chromosomal segregation to prevent chromosomal instability<\/strong>. Autophagy. 2021;17(3):796-813. doi:10.1080\/15548627.2020.1764727.<\/p>\n <\/p>\n <\/p>\n\n\t\t\t\t\tSelected Projects<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t Dr Thomas and Dr Kozma are renowned for their discoveries related to the mTORC1\/S6K1\/4E-BP1 signalling pathway, having obtained FDA approval for the use of rapamycin in different types of cancer and to launch clinical trials based on the use of specific mTOR dual inhibitors.<\/p>\n Dr Tauler has worked extensively on the glycolytic pathway and its control through mitogenic signals. Some of his studies on PF2K bifunctionality are included in leading Biochemistry textbooks<\/p>\n\t\t\t\t Metabolism and cancer Summary The Metabolism and Cancer group includes Doctors George Thomas, Sara Kozma, Albert Tauler and Antonio Gentilella. The program focuses on the kinase signalling of the mammalian target of rapamycin complex 1 (mTORC1) and its main metabolic cascade responses, including ribosome biogenesis, control of translation, metabolic reprogramming, autophagy, lysosomal transport and cell […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":448,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-1865","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2024-11-19 21:11:36","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/1865"}],"collection":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/comments?post=1865"}],"version-history":[{"count":12,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/1865\/revisions"}],"predecessor-version":[{"id":24621,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/1865\/revisions\/24621"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/448"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media?parent=1865"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nImpaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death<\/strong>. Blood. 2021;137(24):3351-3364. doi:10.1182\/blood.2020007452.\n\n
\n\n\t\tThomas, George\n\t<\/h4>\n
\n\t\t\n\t\tgthomas@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tPrincipal investigators\n\t<\/h2>\n\t\t\t\t
\n\n\t\tThomas, George\n\t<\/h4>\n
\n\t\t\n\t\tgthomas@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t
\n\n\t\tGentilella, Antonio\n\t<\/h4>\n
\n\t\t\n\t\tagentilella@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t
\n\n\t\tTauler Girona, Albert\n\t<\/h4>\n
\n\t\t\n\t\tatauler@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t
\n\n\t\tPelletier, Joffrey\n\t<\/h4>\n
\n\t\t\n\t\tjpelletier@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tRELATED LINKS\n\t<\/h4>\n
\n\t\t\n\t\t@A_Gentilella\n\t\t<\/a>\n\t<\/h4>\n
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\n\t\tRelated news\n\t<\/h2>\n\t\t\n\t\t\t\t<\/a>\n\t\t\tA study of IDIBELL and IDIBGI evaluates the efficacy of an anti-tumour drug against obesity<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t01\/08\/2022\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIn adverse conditions, tumor cells create ribosome reservoirs that allow them to survive<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t29\/11\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIDIBELL receives more than one and a half million euros from AECC to fund cancer research projects<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t17\/11\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tA new study deciphers the mechanisms involved in antitumor activity after inhibition of ribosome synthesis<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t09\/02\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tThe study of lysosomal function during cell division enables the identification of a new biomarker for chromosomal instability<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t07\/07\/2020\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tRibosome biogenesis senses nucleotide levels to preserve DNA integrity<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t23\/06\/2020\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tAn IDIBELL and UB research team demonstrates the involvement of glucose in the growth of tumor cells<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t04\/12\/2019\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tNew combined treatment shows promise in Hepatocellular Carcinoma<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t27\/06\/2018\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tA new ribosomal biogenesis regulation point to treat cancer and 5q- syndrome<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t29\/06\/2017\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tA Nature study reinforces the contribution of S6K1 kinase in obesity and aging<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t08\/02\/2017\t\t\t\t\t\t\t\n\t\t\n\n","protected":false},"excerpt":{"rendered":"