{"id":1865,"date":"2019-09-26T13:10:14","date_gmt":"2019-09-26T11:10:14","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=1865"},"modified":"2025-06-11T10:50:02","modified_gmt":"2025-06-11T08:50:02","slug":"cancer-metabolism","status":"publish","type":"page","link":"https:\/\/idibell.cat\/en\/research\/cancer-area\/molecular-mechanisms-and-experimental-therapy-in-oncology-program-oncobell\/cancer-metabolism\/","title":{"rendered":"Cancer metabolism"},"content":{"rendered":"\n<h1>\n\t\tCancer metabolism\n\t<\/h1>\n<h3>\n\t\tSummary\n\t<\/h3>\n\t<p>The Metabolism and Cancer group includes Doctors George Thomas, Sara Kozma, Albert Tauler and Antonio Gentilella. The program focuses on the kinase signalling of the mammalian target of rapamycin complex 1 (mTORC1) and its main metabolic cascade responses, including ribosome biogenesis, control of translation, metabolic reprogramming, autophagy, lysosomal transport and cell proliferation. The group&#8217;s aim is to unveil metabolic vulnerabilities in cancer to promote new clinical treatments, using colorectal cancer (CRC) and other c-MYC driven tumor models and by interacting with oncologists and pharmaceutical companies.<\/p>\n<h2>415<\/h2>\n<h2>Publications<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/07\/metabolism-and-cancer3-1.png\" alt=\"metabolism-and-cancer3\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"metabolism-and-cancer3\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">Strategic lines<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Ribosome biogenesis and biomass production in tumors &#8211; Antonio Gentilella<\/li>\n<li>Metabolic resistance of tumors: unraveling metabolic vulnerabilities &#8211; Antonio Gentilella<\/li>\n<li>Translational reprogramming in oncogenic transformation &#8211; Antonio Gentilella<\/li>\n<li>Cancer stem cells and translational control &#8211; Joffrey Pelletier<\/li>\n<li>Ribo-inflamma and the Plasticity of Differentiation &#8211; Joffrey Pelletier<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Selected Publications<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Fuentes,P;Pelletier,J;Gentilella,A, Decoding ribosome complexity: role of ribosomal proteins in cancer and disease, NAR Cancer, 2024;6(3):doi:10.1093\/narcan\/zcae032<\/li>\n<li>Lluch A, Veiga SR, Latorre J, Moreno Navarrete JM, Bonifaci N, Nguyen VD, Zhou Y, Horing M, Liebisch G, Olkkonen VM, Llobet Navas D, Thomas G, Rodriguez Barrueco R, Fern\u00e1ndez Real JM, Kozma SC, Ortega FJ. A compound directed against S6K1 hampers fat mass expansion and mitigates diet-induced hepatosteatosis. JCI Insight. 2022;7(14):doi:10.1172\/jci.insight.150461.<\/li>\n<li>Almacellas E, Garcia Cajide M, Tauler A, Mauvezin C. Analysis of Autophagic Vesicles in Mitotic Cells. Methods Mol Biol. 2022;2445127-137. doi:10.1007\/978-1-0716-2071-7_9.<\/li>\n<li>Pons C, Almacellas E, Tauler A, Mauvezin C. Detection of Nuclear Biomarkers for Chromosomal Instability. Methods Mol Biol. 2022;2445117-125. doi:10.1007\/978-1-0716-2071-7_8.<\/li>\n<li>Domostegui A, Peddigari S, Mercer CA, Iannizzotto F, Rodriguez ML, Garcia Cajide M, Amador V, Diepstraten ST, Kelly GL, Salazar R, Kozma SC, Kusnadi EP, Kang J, Gentilella A, Pearson RB, Thomas G, Pelletier J.<br \/>\nImpaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death. Blood. 2021;137(24):3351-3364. doi:10.1182\/blood.2020007452.<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Selected Projects<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>LABAE247418PELL. Targeting the reprogramming of the translational machinery to prevent plasticity in colorectal cancer.. Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer (AECC). Budget: 299.956,33\u20ac. 2024-2027. PI: PELLETIER, JOFFREY.<\/li>\n<li>POSTD211561FUEN. Overcoming resistance to therapy in Colorectal Cancer by attacking the 40S-LARP1-5&#8217;TOPs anabolic reservoir. Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer (AECC). Budget: 165.000\u20ac. 2021-2026. PI: Gentilella, Antonio.<\/li>\n<li>LABAE20040GENT. Overcoming resistance to therapy in Colorectal Cancer by attacking the 40S-LARP1-5&#8217;TOPs anabolic reservoir. Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer (AECC). Budget: 150.000\u20ac. 2020-2025. PI: Gentilella, Antonio.<\/li>\n<li>PID2021-122125NB-I00. Role of the 40S-LARP1 complex for the maintenance of tumor anabolic potential in colorectal cancer. Ministerio de Ciencie y Innovacion. Budget: 256.000\u20ac. 2022-2026. PI: Antonio Gentilella.<\/li>\n<li>PID2022-141127OA-I00. Bloqueo de la biog\u00e9nesis ribisomal y la inflamaci\u00f3n celular aut\u00f3noma como nueva terapia de diferenciaci\u00f3n en el c\u00e1ncer colorectal. Ministerio de Ciencia e Innovaci\u00f3n . Budget: 260.000\u20ac. 2023-2026. PI: Joffrey Pelletier.<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\">More Information<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-3\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<p>Dr Thomas and Dr Kozma are renowned for their discoveries related to the mTORC1\/S6K1\/4E-BP1 signalling pathway, having obtained FDA approval for the use of rapamycin in different types of cancer and to launch clinical trials based on the use of specific mTOR dual inhibitors.<\/p>\n<p>Dr Tauler has worked extensively on the glycolytic pathway and its control through mitogenic signals. Some of his studies on PF2K bifunctionality are included in leading Biochemistry textbooks<\/p>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/07\/Antonio-Gentilella-q-150x150.jpg\" alt=\"Antonio-Gentilella-q\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Antonio-Gentilella-q\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tThomas, George\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:gthomas@idibell.cat\" title=\"gthomas@idibell.cat\"  target=\"_blank\"  rel=\"noopener\">\n\t\tgthomas@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tPrincipal investigators\n\t<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/07\/Antonio-Gentilella-q-150x150.jpg\" alt=\"Antonio-Gentilella-q\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Antonio-Gentilella-q\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tGentilella, Antonio\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:agentilella@idibell.cat\" title=\"agentilella@idibell.cat\"  target=\"_blank\"  rel=\"noopener\">\n\t\tagentilella@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2019\/09\/tauler-girona-albert-150x150.jpg\" alt=\"tauler-girona-albert\" itemprop=\"image\" title=\"tauler-girona-albert\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tTauler Girona, Albert\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:atauler@idibell.cat\" title=\"atauler@idibell.cat\"  target=\"_blank\"  rel=\"noopener\">\n\t\tatauler@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2023\/06\/Joffrey-Pelletier-150x150.jpg\" alt=\"Joffrey-Pelletier\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Joffrey-Pelletier\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tPelletier, Joffrey\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:jpelletier@idibell.cat\" title=\"jpelletier@idibell.cat\"  target=\"_blank\"  rel=\"noopener\">\n\t\tjpelletier@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\tRELATED LINKS\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/A_Gentilella\" title=\"@A_Gentilella\"  target=\"_self\">\n\t\t@A_Gentilella\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tTeam\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tGroup leaders \t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPrincipal investigators\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPostdoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPredoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\tGroup leaders \n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Gentilella, Antonio<\/li>\n<\/ul>\n\t\t\t\t\t\tPrincipal investigators\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Tauler Girona, Albert<\/li>\n<li>Pelletier, Joffrey<\/li>\n<\/ul>\n\t\t\t\t\t\tPostdoctoral researchers\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Fuentes Varela, Pedro<\/li>\n<li>Iannizzotto , Flavia<\/li>\n<\/ul>\n\t\t\t\t\t\tPredoctoral researchers\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Toccaceli, Alessia<\/li>\n<li>Frank, Brandon Edward<\/li>\n<\/ul>\n<h2>\n\t\tRelated news\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/21171\" content=\"A study of IDIBELL and IDIBGI 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The program focuses on the kinase signalling of the mammalian target of rapamycin complex 1 (mTORC1) and its main metabolic cascade responses, including ribosome biogenesis, control of translation, metabolic reprogramming, autophagy, lysosomal transport and cell proliferation. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":448,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"unboxed","site-sidebar-style":"unboxed","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-1865","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2025-07-03 12:19:33","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/1865","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/comments?post=1865"}],"version-history":[{"count":3,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/1865\/revisions"}],"predecessor-version":[{"id":25933,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/1865\/revisions\/25933"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/448"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media?parent=1865"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}