{"id":1807,"date":"2019-09-25T19:23:49","date_gmt":"2019-09-25T17:23:49","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=1807"},"modified":"2024-12-13T14:01:36","modified_gmt":"2024-12-13T13:01:36","slug":"sarcoma-research-group","status":"publish","type":"page","link":"https:\/\/idibell.cat\/en\/research\/cancer-area\/molecular-mechanisms-and-experimental-therapy-in-oncology-program-oncobell\/sarcoma-research-group\/","title":{"rendered":"Sarcoma"},"content":{"rendered":"\n<h1>\n\t\tSarcoma\n\t<\/h1>\n<h3>\n\t\tSummary\n\t<\/h3>\n\t<p>The Sarcoma research group, led by \u00d2scar Martinez-Tirado, is a multidisciplinary group which primarily aims to identify new metastatic markers and broaden the knowledge regarding their biological role in developing sarcomas, as well as identifying new therapeutic targets and validating new prognostic and predictive markers in sarcomas, through preclinical evaluation of new components for their treatment.\u00a0 This preclinical evaluation includes epigenetic, proapoptotic and cell-cycle-blocking drugs.<\/p>\n<h2>147<\/h2>\n<h2>Publications<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/04\/112-sarcoma-omteztirado-def.jpg\" alt=\"112-sarcoma-omteztirado-def\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"112-sarcoma-omteztirado-def\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">Strategic lines<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\tIdentification of metastatic agents and the study of their biological role in developing sarcomas.<br \/>\nIdentification of new therapeutic targets and preclinical evaluation of new compounds to treat sarcomas (Xavier Garc\u00eda del Muro)<br \/>\nIdentification of new prognostic markers for sarcomas (Xavier Garc\u00eda del Muro)\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Selected Publications<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Santana Viera,L;Dassie,JP;Ros\u00e0s Lape\u00f1a,M;Garcia Moncl\u00fas,S;Chic\u00f3n Bosch,M;P\u00e9rez Cap\u00f3,M;Pozo,LD et al, <strong>Combination of protein and cell internalization SELEX identifies a potential RNA therapeutic and delivery platform to treat EphA2-expressing tumors<\/strong>., Mol. Ther.-Nucl. Acids, 2023;32758-772, doi:10.1016\/j.omtn.2023.05.003<\/li>\n<li>Santana Viera,L;Dassie,JP;Ros\u00e0s Lape\u00f1a,M;Garcia Moncl\u00fas,S;Chic\u00f3n Bosch,M;P\u00e9rez Cap\u00f3,M;Pozo,LD et al, <strong>Combination of protein and cell internalization SELEX identifies a potential RNA therapeutic and delivery platform to treat EphA2-expressing tumors.<\/strong>, Mol. Ther.-Nucl. Acids, 2023;32758-772, doi:10.1016\/j.omtn.2023.05.003<\/li>\n<li>Moratalla Navarro,F;Diez Villanueva,A;Garcia Serrano,A;Closa,A;Cordero,D;Sole,X;Guino,E et al, <strong>Identification of a Twelve-microRNA Signature with Prognostic Value in Stage II Microsatellite Stable Colon Cancer<\/strong>, Cancers, 2023;15(13):doi:10.3390\/cancers15133301,<\/li>\n<li>Lauritsen,J;Sauv\u00e9,N;Tryakin,A;Jiang,DM;Huddart,R;Heng,DYC;Terbuch,A et al, <strong>Outcomes of relapsed clinical stage I versus de novo metastatic testicular cancer patients: an analysis of the IGCCCG Update database<\/strong>, Br. J. Cancer, 2023;doi:10.1038\/s41416-023-02443-3<\/li>\n<li>Sternberg,CN;Petrylak,DP;Bellmunt,J;Nishiyama,H;Necchi,A;Gurney,H;Lee,JL et al, <strong>FORT-1: Phase II\/III Study of Rogaratinib Versus Chemotherapy in Patients With Locally Advanced or Metastatic Urothelial Carcinoma Selected Based on FGFR1\/3 mRNA Expression<\/strong>., J. Clin. Oncol., 2023;41(3):629-639, doi:10.1200\/JCO.21.02303<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Selected Projects<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>FIS23059. <strong>Terapia de tumores de c\u00e9lulas germinales basada en linfocitos infiltrantes de tumores aut\u00f3logos (ARES)<\/strong>. Instituto de Salud Carlos III (ISCIII). Budget: 1.205.077,03\u20ac. 2024-2027. PI: GARCIA DEL MURO SOLANS, FRANCISCO JAVIER.<\/li>\n<li>FIS21126. <strong>Tratamiento con TILs en tumores avanzados con alteraciones del complejo SWI\/SNF<\/strong>: El estudio TILTS. Instituto de Salud Carlos III (ISCIII). Budget: 1.081.914,72\u20ac. 2022-2025. PI: MARTIN LIBERAL, JUAN JESUS.<\/li>\n<li>21ACL082. <strong>MK-6482-012<\/strong>. MERCK SHARP &amp; DOHME ESPA\u00d1A S.A. Budget: 413.311,5\u20ac. 2021- . PI: Garc\u00eda del Muro Solans, F. Xavier.<\/li>\n<li>19ACL046. <strong>ENSAYO DE FASE 3, ALEATORIZADO Y CONTROLADO CON PLACEBO PARA EVALUAR LA SEGURIDAD Y LA EFICACIA DE PEMBROLIZUMAB (MK-3475) Y LENVATINIB (E7080\/MK-7902) EN COMPARACI\u00d3N CON PEMBROLIZUMAB EN MONOTERAPIA COMO INTERVENCI\u00d3N DE PRIMERA L\u00cdNEA EN PARTICIPANTES CON MELANOMA AVANZADO (LEAP-003)<\/strong>. MERCK SHARP &amp; DOHME ESPA\u00d1A S.A.. Budget: 376.776\u20ac. 2019-2024. PI: Mart\u00edn Liberal, Juan.<\/li>\n<li>20ACL004. <strong>ESTUDIO DE FASE 1, ABIERTO, MULTIC\u00c9NTRICO Y DE VARIOS GRUPOS DE MK-1308 EN COMBINACI\u00d3N CON PEMBROLIZUMAB EN SUJETOS CON TUMORES S\u00d3LIDOS AVANZADOS<\/strong>. MERCK SHARP &amp; DOHME ESPA\u00d1A S.A. Budget: 289.220\u20ac. 2020-2999. PI: Mart\u00edn Liberal, Juan.<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\">Technology transfer<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-3\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\tPAT064-EPH2A APTAMER AND USES THEREOF<br \/>\nIP: Oscar Mart\u00ednez tirado<br \/>\nEP19382451\nLicense: EPH2A APTAMER AND USES THEREOF<br \/>\nPI: Dr. \u00d3scar Mart\u00ednez-Tirado\nSpin-off: Aptadel Therapeutics<br \/>\nPI: Dr. \u00d3scar Mart\u00ednez-Tirado\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-4\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-4\">More Information<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-4\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\tDevelopment of a new orthotopic model for studying sarcoma metastasis<br \/>\nDescription of Ewing&#8217;s sarcoma methylome\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/11\/Oscar-Martinez-Tirado-150x150.jpg\" alt=\"Oscar-Martinez-Tirado\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Oscar-Martinez-Tirado\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tMartinez Tirado, Oscar\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:omartinez@idibell.cat\" title=\"omartinez@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tomartinez@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tPrincipal investigators\n\t<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/11\/Oscar-Martinez-Tirado-150x150.jpg\" alt=\"Oscar-Martinez-Tirado\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Oscar-Martinez-Tirado\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tMartinez Tirado, Oscar\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:omartinez@idibell.cat\" title=\"omartinez@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tomartinez@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/11\/Xavier-Garcia-del-Muro-150x150.jpg\" alt=\"Xavier-Garcia-del-Muro\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Xavier-Garcia-del-Muro\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tGarc\u00eda del Muro, Solans Xavier\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:garciadelmuro@idibell.cat\" title=\"garciadelmuro@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tgarciadelmuro@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\tRELATED LINKS\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/www.facebook.com\/SarcomasIDIBELL\/\" title=\"Facebook\" target=\"_blank\" rel=\"noopener\">\n\t\tFacebook\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/SRGIDIBELL\" title=\"@SRGIDIBELL\" target=\"_blank\" rel=\"noopener\">\n\t\t@SRGIDIBELL\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/omt2007\" title=\"@omt2007\" target=\"_blank\" rel=\"noopener\">\n\t\t@omt2007\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tTeam\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tGroup leaders\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPrincipal investigators\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tClinical researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPostdoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-4\" data-index=\"4\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-4\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPredoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-5\" data-index=\"5\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-5\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tScientific support\t\t\t\t<\/a>\n\t\t\t\t\t\tGroup leaders\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Martinez Tirado, Oscar<\/li>\n<\/ul>\n\t\t\t\t\t\tPrincipal investigators\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Garc\u00eda del Muro, Solans Xavier<\/li>\n<\/ul>\n\t\t\t\t\t\tClinical researchers\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Sanjuan Garriga, Francesc Xavier<\/li>\n<\/ul>\n\t\t\t\t\t\tPostdoctoral researchers\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Chic\u00f3n Bosch, Mariona<\/li>\n<\/ul>\n\t\t\t\t\t\tPredoctoral researchers\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Sanchez Serra, Sara<\/li>\n<\/ul>\n\t\t\t\t\t\tScientific support\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>L\u00f3pez Alemany, Roser<\/li>\n<li>Gris Lorente, Manuel<\/li>\n<\/ul>\n<h2>\n\t\tRelated news\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/22676\" content=\"IDIBELL and the University of Iowa developed a new molecule for targeted treatment against cancer\" \/><meta itemprop=\"datePublished\" content=\"2023-05-30\" \/><meta itemprop=\"dateModified\" content=\"2023-05-29\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" 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itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2021\/02\/Imatge-Nature-Tirado-9.jpg\" \/><meta itemprop=\"width\" content=\"1666\" \/><meta itemprop=\"height\" content=\"626\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2021\/02\/a-new-algorithm-classifies-different-types-of-sarcoma\/\" title=\"A new algorithm classifies different types of sarcoma\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2021\/02\/a-new-algorithm-classifies-different-types-of-sarcoma\/\" title=\"A new algorithm classifies different types of sarcoma\">A new 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content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2021\/01\/aptadel-the-new-idibells-spinoff\/\" title=\"Aptadel, the new IDIBELL's spinoff\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2021\/01\/aptadel-the-new-idibells-spinoff\/\" title=\"Aptadel, the new IDIBELL's spinoff\">Aptadel, the new IDIBELL&#8217;s spinoff<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t22\/01\/2021\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/14395\" content=\"IDIBELL's sarcoma research group will receive one of the new grants of AECC Innova\" \/><meta itemprop=\"datePublished\" content=\"2020-09-10\" \/><meta 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content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/erigin\/\" \/><meta itemprop=\"name\" content=\"Idibell\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/05\/healthio_5-1-scaled.jpeg\" \/><meta itemprop=\"width\" content=\"2560\" \/><meta itemprop=\"height\" content=\"1920\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2018\/10\/idibells-health-innovation-model-visits-barcelona-and-japan\/\" title=\"IDIBELL&#8217;s health innovation model visits Barcelona and Japan\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2018\/10\/idibells-health-innovation-model-visits-barcelona-and-japan\/\" title=\"IDIBELL&#8217;s health innovation model visits Barcelona and Japan\">IDIBELL&#8217;s health innovation model visits Barcelona and Japan<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/erigin\/\">Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t22\/10\/2018\t\t\t\t\t\t\t\n\t\t<!-- .pp-content-posts -->\n\n","protected":false},"excerpt":{"rendered":"<p>Sarcoma Summary The Sarcoma research group, led by \u00d2scar Martinez-Tirado, is a multidisciplinary group which primarily aims to identify new metastatic markers and broaden the knowledge regarding their biological role in developing sarcomas, as well as identifying new therapeutic targets and validating new prognostic and predictive markers in sarcomas, through preclinical evaluation of new components [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":448,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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