Publications<\/h2>\n\t\t\t\t![\"110-tgfbetacancer-fabregat-def\"](\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/04\/110-tgfbetacancer-fabregat-def.jpg\" "\\"110-tgfbetacancer-fabregat-def\\"")
\n\t\t\t\t\tStrategic lines<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t\n- Molecular mechanisms involved in tumour cell migration, plasticity, invasion and metastasis. Role of TGF-beta, EGF and IFN in these processes.<\/li>\n
- Exosomes and MicroRNAs as promoters of the metastatic niche: cross-talk with the TGF-beta pathway.<\/li>\n
- Role of the NADPH oxidase (NOX) family as mediator of TGF-beta effects. The TGF-beta\/NOX4 axis as regulator of the cellular metabolism and redox balance.<\/li>\n
- Analysis of the tumor-stroma interaction in cancer initiation and progression.<\/li>\n<\/ul>\n\t\t\t\t\tSelected Publications<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t
Penuelas Haro I, Espinosa Sotelo R, Crosas Molist E, Herranz Iturbide M, Caballero Diaz D, Alay A, Sole X, Ramos E, Serrano T, Martinez Chantar ML, Knaus UG, Cuezva JM, Zorzano A, Bertran E, Fabregat I. The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression<\/strong>. Hepatology. 2022;doi:10.1002\/hep.32702.<\/p>\nVaquero J, Pavy A, Gonzalez Sanchez E, Meredith M, Arbelaiz A, Fouassier L. Genetic alterations shaping tumor response to anti-EGFR therapies<\/strong>. Drug Resist Updat. 2022;64100863-100863. doi:10.1016\/j.drup.2022.100863.<\/p>\nEspinet E, Klein L, Pur\u00e9 E, Singh SK. Mechanisms of PDAC subtype heterogeneity and therapy response<\/strong>. Trends Cancer. 2022;8(12):1060-1071. doi:10.1016\/j.trecan.2022.08.005.<\/p>\nVinyals A, Ferreres JR, Calbet Llopart N, Ramos R, Tell Mart\u00ed G, Carrera C, Marcoval J, Puig S, Malvehy J, Puig Butille JA, Fabra \u00c0. Oncogenic properties via MAPK signaling of the SOX5-RAF1 fusion gene identified in a wild-type NRAS\/BRAF giant congenital nevus<\/strong>. Pigment Cell Melanoma Res. 2022;35(4):450-460. doi:10.1111\/pcmr.13044.<\/p>\nGoikoetxea Usandizaga N, Serrano Maci\u00e1 M, Delgado TC, Sim\u00f3n J, Fern\u00e1ndez Ramos D, Barriales D, Cornide ME, Jim\u00e9nez M, P\u00e9rez Redondo M, Lachiondo Ortega S, Rodr\u00edguez Agudo R, Bizkarguenaga M, Zalamea JD, Pasco ST, Caballero D\u00edaz D, Alfano B, Bravo M, Gonz\u00e1lez Recio I, Mercado G\u00f3mez M, Gil Pitarch C, Mabe J, Gracia Sancho J, Abecia L, Lorenzo \u00d3, Mart\u00edn Sanz P, Abrescia N, Sabio G, Rinc\u00f3n M, Anguita J, Mi\u00f1ambres E, Mart\u00edn C, Berenguer M, Fabregat I, Casado M, Peralta C, Varela Rey M, Mart\u00ednez Chantar ML. Mitochondrial bioenergetics boost macrophages activation promoting liver regeneration in metabolically compromised animals<\/strong>. Hepatology. 2022;75(3):550-566. doi:10.1002\/hep.32149.<\/p>\n\t\t\t\t\tSelected Projects<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t19MEC012. Nuevas aproximaciones experimentales para analizar el papel de la NADPH oxidasa NOX4 en regeneraci\u00f3n y c\u00e1ncer hep\u00e1ticos. Relaci\u00f3n con la v\u00eda del TGF-beta<\/strong>. Ministerio de Ciencia e Innovaci\u00f3n. Budget: 338800. 2019-2022. PI: Fabregat Romero, Mar\u00eda Isabel.<\/p>\nAEC21009. Towards a precision medicine using TGF-\u00df inhibitors in hepatocellular carcinoma and cholangiocarcinoma<\/strong>. Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer (AECC). Budget: 299813,75. 2021-2024. PI: Fabregat Romero, Mar\u00eda Isabel.<\/p>\n20MEC015. Diseccionando el papel terap\u00e9utico de la NADPH oxidasa NOX4 en colangiocarcinoma por medio de secuenciaci\u00f3n masiva de RNA en c\u00e9lula \u00fanica (NOX4CHOL)<\/strong>. Ministerio de Ciencia e Innovaci\u00f3n. Budget: 181500. 2020-2023. PI: Vaquero Rodr\u00edguez, Javier.<\/p>\n20MEC023. DESARROLLO PRECL\u00cdNICO DE UN NUEVO ACTIVO MODULADOR DE LA FIBROSIS Y LA SENESCENCIA PARA EL TRATAMIENTO DE LA ENFERMEDAD DE H\u00cdGADO GRASO NO-ALCOH\u00d3LICO (HEPATOSEN)<\/strong>. Ministerio de Ciencia e Innovaci\u00f3n. Budget: 159287,29. 2020-2022. PI: Fabregat Romero, Mar\u00eda Isabel.<\/p>\n21PSJ005. Dissecting the role of the hepatocyte Epidermal Growth Factor Receptor (EGFR) pathway in the cellular interactome within the liver fibrotic niche<\/strong>. FUNDACI\u00d3N RAM\u00d3N ARECES. Budget: 112000. 2021-2024. PI: Fabregat Romero, Mar\u00eda Isabel.<\/p>\n\t\t\t\t\tTechnology transfer<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\tLicense: ANTINOX
\nPI: Dra. Isabel Fabregat\n\t\t\t\t\tMore Information<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\tCoordination of the European consortium IT-LIVER (inhibition of TGF-\u03b2 in liver diseases) – Marie Curie International Training Network (ITN) programme.
\nNational projects (Pla Estatal, FIS), private foundations (Marat\u00f3 TV3 and AECC) and projects with pharmaceutical companies (Digna – Spain, 4SC AG-Germany)\n\t\t\t\t![\"Isabel-Fabregat22\"](\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/11\/Isabel-Fabregat22-150x150.jpg\" "\\"Isabel-Fabregat22\\"")
\n\n\t\tFabregat Romero, Maria Isabel\n\t<\/h4>\n\n\t\t\n\t\tifabregat@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\n\t\tPrincipal investigators\n\t<\/h2>\n\t\t\t\t\n\n\t\tFabregat Romero, Maria Isabel\n\t<\/h4>\n\n\t\t\n\t\tifabregat@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t![\"Angels-Fabra\"](\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/11\/Angels-Fabra-150x150.jpg\" "\\"Angels-Fabra\\"")
\n\n\t\tFabra Fres, Angels\n\t<\/h4>\n\n\t\t\n\t\tafabra@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t![\"Elisa-Espinet\"](\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/06\/Elisa-Espinet-150x150.jpg\" "\\"Elisa-Espinet\\"")
\n\n\t\tEspinet, Elisa\n\t<\/h4>\n\n\t\t\n\t\teespinet@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\n\t\tRELATED LINKS\n\t<\/h4>\n\n\t\t\n\t\tIT-liver\n\t\t<\/a>\n\t<\/h4>\n\n\t\t\n\t\tFacebook IT-Liver\n\t\t<\/a>\n\t<\/h4>\n\n\t\t\n\t\t@IsabelFabregat\n\t\t<\/a>\n\t<\/h4>\n\n\t\tTeam\n\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\tGroup leaders\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPrincipal investigators\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tClinical researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPostdoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadors\/es predoctorals \t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tScientific support\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tCollaborators\t\t\t\t<\/a>\n\t\t\t\t\t\tGroup leaders\n\t\t\t\t\t\t\t\t\t\t\t\n- Fabregat Romero, Mar\u00eda Isabel<\/li>\n<\/ul>\n\t\t\t\t\t\tPrincipal investigators\n\t\t\t\t\t\t\t\t\t\t\t
\n- Fabra Fres, Angels<\/li>\n
- Espinet, Elisa<\/li>\n<\/ul>\n\t\t\t\t\t\tClinical researchers\n\t\t\t\t\t\t\t\t\t\t\t
\n- Ferreres Riera, Josep Ram\u00f3n<\/li>\n
- Calvo Campos, Mariona<\/li>\n
- Ramos Rubio, Emili<\/li>\n
- Serrano Pinol, Teresa<\/li>\n<\/ul>\n\t\t\t\t\t\tPostdoctoral researchers\n\t\t\t\t\t\t\t\t\t\t\t
\n- Pe\u00f1uelas Haro, Irene<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadors\/es predoctorals \n\t\t\t\t\t\t\t\t\t\t\t
\n- Espinosa Sotelo, Rut<\/li>\n
- Amengual Segura, Josep<\/li>\n
- \u00a0Cantos Cortes Ana<\/li>\n
- Gonfaus Ortiz, Gemma<\/li>\n
- Jim\u00e9nez-Arriola, Mart\u00edn<\/li>\n<\/ul>\n\t\t\t\t\t\tScientific support\n\t\t\t\t\t\t\t\t\t\t\t
\n- Vinyals Rioseco, Antonia<\/li>\n
- Bertran Rodriguez, Esther<\/li>\n<\/ul>\n\t\t\t\t\t\tCollaborators\n\t\t\t\t\t\t\t\t\t\t\t
\n- Vaquero Rodr\u00edguez, Javier<\/li>\n
- Gonzalez Sanchez, Maria Esther<\/li>\n<\/ul>\n
\n\t\tRelated news\n\t<\/h2>\n\t\t\n\t\t\t\t<\/a>\n\t\t\tThe “la Caixa” Foundation promotes a promising study against pancreatic cancer<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t24\/11\/2023\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tNew advances in the analysis of the mechanisms that explain the dual role of TGF-beta in hepatocellular carcinoma<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t31\/08\/2023\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIDIBELL offers 10 projects for incoming INPhINIT fellowships<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t18\/11\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIDIBELL receives more than one and a half million euros from AECC to fund cancer research projects<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t17\/11\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIDIBELL participates in a study aimed to reduce the likelihood of liver failure in older transplant donors<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t01\/10\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIDIBELL researchers participate in a study that describes a new mechanism of resistance to hepatocellular carcinoma treatment<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t09\/06\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tA new study about the reprogramming of lipid metabolism to combat cellular hepatocarcinoma<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t31\/05\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIsabel Fabregat receives a grant from the Ram\u00f3n Areces Foundation to study liver fibrosis<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t30\/04\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tDepletion of NOX4 protein improves liver regeneration<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t03\/02\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tScientists discover the implication of a new protein involved in liver cancer<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t28\/10\/2019\t\t\t\t\t\t\t\n\t\t\n\n","protected":false},"excerpt":{"rendered":"TGF-beta and cancer Summary The group consists of four principal investigators, whose lines of research have as a common link to advance in the knowledge of the molecular mechanisms that influence tumor cell plasticity and the tumor-stroma interactions. The group has a special interest on the role of transforming growth factor (TGF)-\u03b2 in regulating these […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":448,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"publishpress_future_action":{"enabled":false,"date":"2024-05-05 05:30:37","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/1783"}],"collection":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/comments?post=1783"}],"version-history":[{"count":5,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/1783\/revisions"}],"predecessor-version":[{"id":23439,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/1783\/revisions\/23439"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/448"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media?parent=1783"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Penuelas Haro I, Espinosa Sotelo R, Crosas Molist E, Herranz Iturbide M, Caballero Diaz D, Alay A, Sole X, Ramos E, Serrano T, Martinez Chantar ML, Knaus UG, Cuezva JM, Zorzano A, Bertran E, Fabregat I. The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression<\/strong>. Hepatology. 2022;doi:10.1002\/hep.32702.<\/p>\n Vaquero J, Pavy A, Gonzalez Sanchez E, Meredith M, Arbelaiz A, Fouassier L. Genetic alterations shaping tumor response to anti-EGFR therapies<\/strong>. Drug Resist Updat. 2022;64100863-100863. doi:10.1016\/j.drup.2022.100863.<\/p>\n Espinet E, Klein L, Pur\u00e9 E, Singh SK. Mechanisms of PDAC subtype heterogeneity and therapy response<\/strong>. Trends Cancer. 2022;8(12):1060-1071. doi:10.1016\/j.trecan.2022.08.005.<\/p>\n Vinyals A, Ferreres JR, Calbet Llopart N, Ramos R, Tell Mart\u00ed G, Carrera C, Marcoval J, Puig S, Malvehy J, Puig Butille JA, Fabra \u00c0. Oncogenic properties via MAPK signaling of the SOX5-RAF1 fusion gene identified in a wild-type NRAS\/BRAF giant congenital nevus<\/strong>. Pigment Cell Melanoma Res. 2022;35(4):450-460. doi:10.1111\/pcmr.13044.<\/p>\n Goikoetxea Usandizaga N, Serrano Maci\u00e1 M, Delgado TC, Sim\u00f3n J, Fern\u00e1ndez Ramos D, Barriales D, Cornide ME, Jim\u00e9nez M, P\u00e9rez Redondo M, Lachiondo Ortega S, Rodr\u00edguez Agudo R, Bizkarguenaga M, Zalamea JD, Pasco ST, Caballero D\u00edaz D, Alfano B, Bravo M, Gonz\u00e1lez Recio I, Mercado G\u00f3mez M, Gil Pitarch C, Mabe J, Gracia Sancho J, Abecia L, Lorenzo \u00d3, Mart\u00edn Sanz P, Abrescia N, Sabio G, Rinc\u00f3n M, Anguita J, Mi\u00f1ambres E, Mart\u00edn C, Berenguer M, Fabregat I, Casado M, Peralta C, Varela Rey M, Mart\u00ednez Chantar ML. Mitochondrial bioenergetics boost macrophages activation promoting liver regeneration in metabolically compromised animals<\/strong>. Hepatology. 2022;75(3):550-566. doi:10.1002\/hep.32149.<\/p>\n\t\t\t\t\tSelected Projects<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t 19MEC012. Nuevas aproximaciones experimentales para analizar el papel de la NADPH oxidasa NOX4 en regeneraci\u00f3n y c\u00e1ncer hep\u00e1ticos. Relaci\u00f3n con la v\u00eda del TGF-beta<\/strong>. Ministerio de Ciencia e Innovaci\u00f3n. Budget: 338800. 2019-2022. PI: Fabregat Romero, Mar\u00eda Isabel.<\/p>\n AEC21009. Towards a precision medicine using TGF-\u00df inhibitors in hepatocellular carcinoma and cholangiocarcinoma<\/strong>. Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer (AECC). Budget: 299813,75. 2021-2024. PI: Fabregat Romero, Mar\u00eda Isabel.<\/p>\n 20MEC015. Diseccionando el papel terap\u00e9utico de la NADPH oxidasa NOX4 en colangiocarcinoma por medio de secuenciaci\u00f3n masiva de RNA en c\u00e9lula \u00fanica (NOX4CHOL)<\/strong>. Ministerio de Ciencia e Innovaci\u00f3n. Budget: 181500. 2020-2023. PI: Vaquero Rodr\u00edguez, Javier.<\/p>\n 20MEC023. DESARROLLO PRECL\u00cdNICO DE UN NUEVO ACTIVO MODULADOR DE LA FIBROSIS Y LA SENESCENCIA PARA EL TRATAMIENTO DE LA ENFERMEDAD DE H\u00cdGADO GRASO NO-ALCOH\u00d3LICO (HEPATOSEN)<\/strong>. Ministerio de Ciencia e Innovaci\u00f3n. Budget: 159287,29. 2020-2022. PI: Fabregat Romero, Mar\u00eda Isabel.<\/p>\n 21PSJ005. Dissecting the role of the hepatocyte Epidermal Growth Factor Receptor (EGFR) pathway in the cellular interactome within the liver fibrotic niche<\/strong>. FUNDACI\u00d3N RAM\u00d3N ARECES. Budget: 112000. 2021-2024. PI: Fabregat Romero, Mar\u00eda Isabel.<\/p>\n\t\t\t\t\tTechnology transfer<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\tLicense: ANTINOX TGF-beta and cancer Summary The group consists of four principal investigators, whose lines of research have as a common link to advance in the knowledge of the molecular mechanisms that influence tumor cell plasticity and the tumor-stroma interactions. The group has a special interest on the role of transforming growth factor (TGF)-\u03b2 in regulating these […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":448,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"publishpress_future_action":{"enabled":false,"date":"2024-05-05 05:30:37","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/1783"}],"collection":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/comments?post=1783"}],"version-history":[{"count":5,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/1783\/revisions"}],"predecessor-version":[{"id":23439,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/1783\/revisions\/23439"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/448"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media?parent=1783"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nPI: Dra. Isabel Fabregat\n\t\t\t\t\tMore Information<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\tCoordination of the European consortium IT-LIVER (inhibition of TGF-\u03b2 in liver diseases) – Marie Curie International Training Network (ITN) programme.
\nNational projects (Pla Estatal, FIS), private foundations (Marat\u00f3 TV3 and AECC) and projects with pharmaceutical companies (Digna – Spain, 4SC AG-Germany)\n\t\t\t\t\n\n\t\tFabregat Romero, Maria Isabel\n\t<\/h4>\n
\n\t\t\n\t\tifabregat@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tPrincipal investigators\n\t<\/h2>\n\t\t\t\t
\n\n\t\tFabregat Romero, Maria Isabel\n\t<\/h4>\n
\n\t\t\n\t\tifabregat@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t
\n\n\t\tFabra Fres, Angels\n\t<\/h4>\n
\n\t\t\n\t\tafabra@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t
\n\n\t\tEspinet, Elisa\n\t<\/h4>\n
\n\t\t\n\t\teespinet@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tRELATED LINKS\n\t<\/h4>\n
\n\t\t\n\t\tIT-liver\n\t\t<\/a>\n\t<\/h4>\n
\n\t\t\n\t\tFacebook IT-Liver\n\t\t<\/a>\n\t<\/h4>\n
\n\t\t\n\t\t@IsabelFabregat\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tTeam\n\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\tGroup leaders\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPrincipal investigators\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tClinical researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPostdoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadors\/es predoctorals \t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tScientific support\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tCollaborators\t\t\t\t<\/a>\n\t\t\t\t\t\tGroup leaders\n\t\t\t\t\t\t\t\t\t\t\t
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\n\t\tRelated news\n\t<\/h2>\n\t\t\n\t\t\t\t<\/a>\n\t\t\tThe “la Caixa” Foundation promotes a promising study against pancreatic cancer<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t24\/11\/2023\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tNew advances in the analysis of the mechanisms that explain the dual role of TGF-beta in hepatocellular carcinoma<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t31\/08\/2023\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIDIBELL offers 10 projects for incoming INPhINIT fellowships<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t18\/11\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIDIBELL receives more than one and a half million euros from AECC to fund cancer research projects<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t17\/11\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIDIBELL participates in a study aimed to reduce the likelihood of liver failure in older transplant donors<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t01\/10\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIDIBELL researchers participate in a study that describes a new mechanism of resistance to hepatocellular carcinoma treatment<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t09\/06\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tA new study about the reprogramming of lipid metabolism to combat cellular hepatocarcinoma<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t31\/05\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIsabel Fabregat receives a grant from the Ram\u00f3n Areces Foundation to study liver fibrosis<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t30\/04\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tDepletion of NOX4 protein improves liver regeneration<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t03\/02\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tScientists discover the implication of a new protein involved in liver cancer<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t28\/10\/2019\t\t\t\t\t\t\t\n\t\t\n\n","protected":false},"excerpt":{"rendered":"