{"id":1783,"date":"2019-09-19T11:25:21","date_gmt":"2019-09-19T09:25:21","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=1783"},"modified":"2025-05-21T14:46:58","modified_gmt":"2025-05-21T12:46:58","slug":"tgf-beta-and-cancer","status":"publish","type":"page","link":"https:\/\/idibell.cat\/en\/research\/cancer-area\/molecular-mechanisms-and-experimental-therapy-in-oncology-program-oncobell\/tgf-beta-and-cancer\/","title":{"rendered":"TGF-beta and cancer"},"content":{"rendered":"\n<h1>\n\t\tTGF-beta and cancer\n\t<\/h1>\n<h3>\n\t\tSummary\n\t<\/h3>\n\t<p>The research group&#8217;s focus is on studying the dual role of transforming growth factor (TGF)-\u03b2 in regulating the initiation and progression of liver cancer, as well as deciphering the relevance of other signaling pathways that interact with it, particularly the epidermal growth factor (EGF). In recent years, we have made progress in studying the TGF-\u03b2 signaling pathway and have identified the production of reactive oxygen species (ROS) mediated by the NADPH oxidase family, particularly NOX4, as a key element in TGF-\u03b2 function.<\/p>\n<p>Currently, we are working on advancing in:<\/p>\n<ul>\n<li>the role of TGF-\u03b2 and oxidative stress in the tumor microenvironment;<\/li>\n<li>identifying new targets related to TGF-\u03b2 or redox stress to guide the search for novel therapeutic strategies for liver cancer;<\/li>\n<li>analyzing which patients may benefit from TGF-\u03b2 pathway inhibition to improve the response of hepatocellular carcinoma to immunotherapy.<\/li>\n<\/ul>\n<h2>268<\/h2>\n<h2>Publications<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2020\/04\/110-tgfbetacancer-fabregat-def.jpg\" alt=\"110-tgfbetacancer-fabregat-def\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"110-tgfbetacancer-fabregat-def\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">Strategic lines<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li><strong>Molecular mechanisms<\/strong> involved in the regulation of liver regeneration, fibrosis, and cancer, with a focus on the role of TGF-\u03b2 and the EGF receptor pathway in these processes.<\/li>\n<li><strong>Function of the NADPH oxidase (NOX) family<\/strong> as mediators of TGF-\u03b2 effects. Regulation of metabolism and cellular redox balance through the TGF-\u03b2\/NOX4 axis.<\/li>\n<li><strong>Tumor-stroma interaction<\/strong> in tumor initiation and progression: role of TGF-\u03b2 in both tumor cells and the stroma. Evaluation of the therapeutic potential of TGF-\u03b2 inhibitors in liver cancer.<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Selected Publications<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>L\u00f3pez Gil,JC;Garc\u00eda Silva,S;Ruiz Ca\u00f1as,L;Navarro,D;Palencia Campos,A;Gir\u00e1ldez Trujillo,A;Earl,J et al, The Peptidoglycan Recognition Protein 1 confers immune evasive properties on pancreatic cancer stem cells, Gut, 2024;73(9):1489-1508, doi:10.1136\/gutjnl-2023-330995<\/li>\n<li>Amengual,J;Alay,A;Vaquero,J;Gonzalez Sanchez,E;Bertran,E;S\u00e1nchez,A;Herrera,B et al, Iron chelation as a new therapeutic approach to prevent senescence and liver fibrosis progression, Cell Death Dis., 2024;15(9):680-680, doi:10.1038\/s41419-024-07063-0<\/li>\n<li>Gonzalez Sanchez,E;Vaquero,J;Caballero Diaz,D;Grzelak,J;Fust\u00e9,NP;Bertran,E;Amengual,J et al, The hepatocyte epidermal growth factor receptor (EGFR) pathway regulates the cellular interactome within the liver fibrotic niche, J. Pathol., 2024;263(4-5):482-495, doi:10.1002\/path.6299<\/li>\n<li>Ferreres,JR;Vinyals,A;Campos Martin,R;Esp\u00edn,R;Podlipnik,S;Ramos,R;Bertran,E et al, PRRX1 silencing is required for metastatic outgrowth in melanoma and is an independent prognostic of reduced survival in patients, Mol. Oncol., 2024;18(10):2471-2494, doi:10.1002\/1878-0261.13688<\/li>\n<li>Ramos,R;Vinyals,A;Campos Martin,R;Cabr\u00e9,E;Bech,JJ;Vaquero,J;Gonzalez Sanchez,E et al, New Insights into the Exosome-Induced Migration of Uveal Melanoma Cells and the Pre-Metastatic Niche Formation in the Liver, Cancers, 2024;16(17):doi:10.3390\/cancers16172977<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Selected Projects<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>PID2021-122551OB-I00. Descifrando el papel de la NADPH oxidasa NOX4 en el carcinoma hepatocelular: relevancia en c\u00e9lulas tumorales y estroma y relaci\u00f3n con la v\u00eda del TGF-beta. Ministerio de Ciencia e Innovaci\u00f3n. Budget: 344850. 2022-2025. PI: FABREGAT ROMERO, MARIA ISABEL.<\/li>\n<li>TRANSCAN2021-237\/AC22\/00034. Targeting ROBOs and SLIT guidance cues in the immunosuppressive stromal context of pancreatic cancer (TRanSLIT). Instituto de Salud Carlos III (ISCIII)\/ Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer (AECC). Budget: 302600. 2023-2025. PI: Espinet Hern\u00e1ndez, Elisa Maria.<\/li>\n<li>PRYGN211279FABR. Towards a precision medicine using TGF-\u00df inhibitors in hepatocellular carcinoma and cholangiocarcinoma. Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer (AECC). Budget: 299813,75. 2021-2025. PI: FABREGAT ROMERO, MARIA ISABEL.<\/li>\n<li>PRE2022-101761. AYUDAS PARA CONTRATOS PREDOCTORALES PARA LA FORMACI\u00d3N DE DOCTORES 2022. Ministerio de Ciencia e Innovaci\u00f3n. Budget: 111758. 2023-2027. PI: FABREGAT ROMERO, MARIA ISABEL.<\/li>\n<li>21PSJ005. Dissecting the role of the hepatocyte Epidermal Growth Factor Receptor (EGFR) pathway in the cellular interactome within the liver fibrotic niche. FUNDACI\u00d3N RAM\u00d3N ARECES. Budget: 112000. 2021-2024. PI: FABREGAT ROMERO, MARIA ISABEL.<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-3\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-3\">Technology transfer<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-3\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\tLicense: ANTINOX<br \/>\nPI: Dra. Isabel Fabregat\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-4\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-4\">More Information<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-4\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\tCoordination of the European consortium IT-LIVER (inhibition of TGF-\u03b2 in liver diseases) &#8211; Marie Curie International Training Network (ITN) programme.<br \/>\nNational projects (Pla Estatal, FIS), private foundations (Marat\u00f3 TV3 and AECC) and projects with pharmaceutical companies (Digna &#8211; Spain, 4SC AG-Germany)\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/11\/Isabel-Fabregat22-150x150.jpg\" alt=\"Isabel-Fabregat22\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Isabel-Fabregat22\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tFabregat Romero, Maria Isabel\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:ifabregat@idibell.cat\" title=\"ifabregat@idibell.cat\"  target=\"_blank\"  rel=\"noopener\">\n\t\tifabregat@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tPrincipal investigators\n\t<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/11\/Isabel-Fabregat22-150x150.jpg\" alt=\"Isabel-Fabregat22\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Isabel-Fabregat22\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tFabregat Romero, Maria Isabel\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:ifabregat@idibell.cat\" title=\"ifabregat@idibell.cat\"  target=\"_blank\"  rel=\"noopener\">\n\t\tifabregat@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\tRELATED LINKS\n\t<\/h4>\n<h4>\n\t\t<a href=\"http:\/\/www.it-liver.eu\/\" title=\"IT-liver\"  target=\"_blank\"  rel=\"noopener\">\n\t\tIT-liver\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/www.facebook.com\/IT-Liver-141184969424873\/\" title=\"Facebook IT-Liver\"  target=\"_blank\"  rel=\"noopener\">\n\t\tFacebook IT-Liver\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/IsabelFabregat\" title=\"@IsabelFabregat\"  target=\"_blank\"  rel=\"noopener\">\n\t\t@IsabelFabregat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tTeam\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tGroup leaders\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tClinical researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPostdoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPredoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-4\" data-index=\"4\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-4\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tScientific support\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-5\" data-index=\"5\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-5\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tCollaborators\t\t\t\t<\/a>\n\t\t\t\t\t\tGroup leaders\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Fabregat Romero, Mar\u00eda Isabel<\/li>\n<\/ul>\n\t\t\t\t\t\tClinical researchers\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Calvo Campos, Mariona<\/li>\n<li>Ramos Rubio, Emili<\/li>\n<li>Serrano Pinol, Teresa<\/li>\n<\/ul>\n\t\t\t\t\t\tPostdoctoral researchers\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Segales Rovira, Paula<\/li>\n<li>Amengual Segura, Josep<\/li>\n<\/ul>\n\t\t\t\t\t\tPredoctoral researchers\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>\u00a0Cantos Cortes Ana<\/li>\n<li>Gonfaus Ortiz, Gemma<\/li>\n<li>Scialpi, Rosanna<\/li>\n<\/ul>\n\t\t\t\t\t\tScientific support\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Bertran Rodriguez, Esther<\/li>\n<\/ul>\n\t\t\t\t\t\tCollaborators\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Vaquero Rodr\u00edguez, Javier<\/li>\n<li>Gonzalez Sanchez, Maria Esther<\/li>\n<\/ul>\n<h2>\n\t\tRelated news\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/24932\" content=\"New advances in research on metastasis in different types of melanoma\" \/><meta itemprop=\"datePublished\" content=\"2024-12-09\" \/><meta itemprop=\"dateModified\" content=\"2024-12-09\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2024\/12\/Fabra-melanoma-Web.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"769\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2024\/12\/new-advances-in-research-on-metastasis-in-different-types-of-melanoma\/\" title=\"New advances in research on metastasis in different types of melanoma\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2024\/12\/new-advances-in-research-on-metastasis-in-different-types-of-melanoma\/\" title=\"New advances in research on metastasis in different types of melanoma\">New advances in research on metastasis in different types of melanoma<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t09\/12\/2024\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/24585\" content=\"Iron accumulation and cellular senescence in liver fibrosis: new perspectives on treatment\" \/><meta itemprop=\"datePublished\" content=\"2024-09-25\" \/><meta itemprop=\"dateModified\" content=\"2024-09-20\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2024\/09\/Fabregat-fibrosi-hepatica-ferro-WEB.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2024\/09\/iron-accumulation-and-cellular-senescence-in-liver-fibrosis-new-perspectives-on-treatment\/\" title=\"Iron accumulation and cellular senescence in liver fibrosis: new perspectives on treatment\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2024\/09\/iron-accumulation-and-cellular-senescence-in-liver-fibrosis-new-perspectives-on-treatment\/\" title=\"Iron accumulation and cellular senescence in liver fibrosis: new perspectives on treatment\">Iron accumulation and cellular senescence in liver fibrosis: new perspectives on treatment<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t25\/09\/2024\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/24298\" content=\"The role of the epidermal growth factor receptor in chronic liver damage has been proven\" \/><meta itemprop=\"datePublished\" content=\"2024-06-19\" \/><meta itemprop=\"dateModified\" content=\"2024-06-19\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2024\/06\/Kick-off-meeting-ramon-areces_16_9-scaled.jpg\" \/><meta itemprop=\"width\" content=\"2560\" \/><meta itemprop=\"height\" content=\"1440\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2024\/06\/the-role-of-the-epidermal-growth-factor-receptor-in-chronic-liver-damage-has-been-proven\/\" title=\"The role of the epidermal growth factor receptor in chronic liver damage has been proven\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2024\/06\/the-role-of-the-epidermal-growth-factor-receptor-in-chronic-liver-damage-has-been-proven\/\" title=\"The role of the epidermal growth factor receptor in chronic liver damage has been proven\">The role of the epidermal growth factor receptor in chronic liver damage has been proven<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t19\/06\/2024\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/23953\" content=\"Dr. Teresa Serrano Pi\u00f1ol, new Academic of the Royal Academy of Medicine of Catalonia\" \/><meta itemprop=\"datePublished\" content=\"2024-04-19\" \/><meta itemprop=\"dateModified\" content=\"2024-04-19\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2024\/04\/ts-1-scaled.jpg\" \/><meta itemprop=\"width\" content=\"2560\" \/><meta itemprop=\"height\" content=\"1280\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2024\/04\/dr-teresa-serrano-pinol-new-academic-of-the-royal-academy-of-medicine-of-catalonia\/\" title=\"Dr. Teresa Serrano Pi\u00f1ol, new Academic of the Royal Academy of Medicine of Catalonia\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2024\/04\/dr-teresa-serrano-pinol-new-academic-of-the-royal-academy-of-medicine-of-catalonia\/\" title=\"Dr. Teresa Serrano Pi\u00f1ol, new Academic of the Royal Academy of Medicine of Catalonia\">Dr. Teresa Serrano Pi\u00f1ol, new Academic of the Royal Academy of Medicine of Catalonia<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t19\/04\/2024\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/23222\" content=\"The \"la Caixa\" Foundation promotes a promising study against pancreatic cancer\" \/><meta itemprop=\"datePublished\" content=\"2023-11-24\" \/><meta itemprop=\"dateModified\" content=\"2025-01-09\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2023\/11\/Rovira-Espinet-scaled.jpg\" \/><meta itemprop=\"width\" content=\"2560\" \/><meta itemprop=\"height\" content=\"1280\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2023\/11\/the-la-caixa-foundation-promotes-a-promising-study-against-pancreatic-cancer\/\" title=\"The \"la Caixa\" Foundation promotes a promising study against pancreatic cancer\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2023\/11\/the-la-caixa-foundation-promotes-a-promising-study-against-pancreatic-cancer\/\" title=\"The \"la Caixa\" Foundation promotes a promising study against pancreatic cancer\">The &#8220;la Caixa&#8221; Foundation promotes a promising study against pancreatic cancer<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t24\/11\/2023\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/22910\" content=\"New advances in the analysis of the mechanisms that explain the dual role of TGF-beta in hepatocellular carcinoma\" \/><meta itemprop=\"datePublished\" content=\"2023-08-31\" \/><meta itemprop=\"dateModified\" content=\"2023-10-06\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2023\/08\/IMG-20220919-WA0002.jpg\" \/><meta itemprop=\"width\" content=\"1600\" \/><meta itemprop=\"height\" content=\"800\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2023\/08\/new-advances-in-the-analysis-of-the-mechanisms-that-explain-the-dual-role-of-tgf-beta-in-hepatocellular-carcinoma\/\" title=\"New advances in the analysis of the mechanisms that explain the dual role of TGF-beta in hepatocellular carcinoma\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2023\/08\/new-advances-in-the-analysis-of-the-mechanisms-that-explain-the-dual-role-of-tgf-beta-in-hepatocellular-carcinoma\/\" title=\"New advances in the analysis of the mechanisms that explain the dual role of TGF-beta in hepatocellular carcinoma\">New advances in the analysis of the mechanisms that explain the dual role of TGF-beta in hepatocellular carcinoma<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t31\/08\/2023\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/19188\" content=\"IDIBELL offers 10 projects for incoming INPhINIT fellowships\" \/><meta itemprop=\"datePublished\" content=\"2021-11-18\" \/><meta itemprop=\"dateModified\" content=\"2021-11-25\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2021\/11\/FFBWFunXoAQfIw4-1.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2021\/11\/idibell-offers-10-projects-for-incoming-inphinit-fellowships\/\" title=\"IDIBELL offers 10 projects for incoming INPhINIT fellowships\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2021\/11\/idibell-offers-10-projects-for-incoming-inphinit-fellowships\/\" title=\"IDIBELL offers 10 projects for incoming INPhINIT fellowships\">IDIBELL offers 10 projects for incoming INPhINIT fellowships<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t18\/11\/2021\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/18921\" content=\"IDIBELL receives more than one and a half million euros from AECC to fund cancer research projects\" \/><meta itemprop=\"datePublished\" content=\"2021-11-17\" \/><meta itemprop=\"dateModified\" content=\"2022-12-20\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2021\/11\/logo.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2021\/11\/idibell-receives-more-than-one-and-a-half-million-euros-from-aecc-to-fund-cancer-research-projects\/\" title=\"IDIBELL receives more than one and a half million euros from AECC to fund cancer research projects\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2021\/11\/idibell-receives-more-than-one-and-a-half-million-euros-from-aecc-to-fund-cancer-research-projects\/\" title=\"IDIBELL receives more than one and a half million euros from AECC to fund cancer research projects\">IDIBELL receives more than one and a half million euros from AECC to fund cancer research projects<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t17\/11\/2021\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/18561\" content=\"IDIBELL participates in a study aimed to reduce the likelihood of liver failure in older transplant donors\" \/><meta itemprop=\"datePublished\" content=\"2021-10-01\" \/><meta itemprop=\"dateModified\" content=\"2021-10-01\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2021\/10\/foto-grupo-dic-2020-scaled.jpg\" \/><meta itemprop=\"width\" content=\"2560\" \/><meta itemprop=\"height\" content=\"1440\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2021\/10\/idibell-participates-in-a-study-aimed-to-reduce-the-likelihood-of-liver-failure-in-older-transplant-donors\/\" title=\"IDIBELL participates in a study aimed to reduce the likelihood of liver failure in older transplant donors\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2021\/10\/idibell-participates-in-a-study-aimed-to-reduce-the-likelihood-of-liver-failure-in-older-transplant-donors\/\" title=\"IDIBELL participates in a study aimed to reduce the likelihood of liver failure in older transplant donors\">IDIBELL participates in a study aimed to reduce the likelihood of liver failure in older transplant donors<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t01\/10\/2021\t\t\t\t\t\t\t\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/17263\" content=\"IDIBELL researchers participate in a study that describes a new mechanism of resistance to hepatocellular carcinoma treatment\" \/><meta itemprop=\"datePublished\" content=\"2021-06-09\" \/><meta itemprop=\"dateModified\" content=\"2021-06-09\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2021\/06\/NO53-Fabregat_Cell-Death-Disease-Imatge.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2021\/06\/idibell-researchers-participate-in-a-study-that-describes-a-new-mechanism-of-resistance-to-hepatocellular-carcinoma-treatment\/\" title=\"IDIBELL researchers participate in a study that describes a new mechanism of resistance to hepatocellular carcinoma treatment\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2021\/06\/idibell-researchers-participate-in-a-study-that-describes-a-new-mechanism-of-resistance-to-hepatocellular-carcinoma-treatment\/\" title=\"IDIBELL researchers participate in a study that describes a new mechanism of resistance to hepatocellular carcinoma treatment\">IDIBELL researchers participate in a study that describes a new mechanism of resistance to hepatocellular carcinoma treatment<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t09\/06\/2021\t\t\t\t\t\t\t\n\t\t<!-- .pp-content-posts -->\n\n","protected":false},"excerpt":{"rendered":"<p>TGF-beta and cancer Summary The research group&#8217;s focus is on studying the dual role of transforming growth factor (TGF)-\u03b2 in regulating the initiation and progression of liver cancer, as well as deciphering the relevance of other signaling pathways that interact with it, particularly the epidermal growth factor (EGF). In recent years, we have made progress [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":448,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-1783","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2025-06-09 17:12:55","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/1783","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/comments?post=1783"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/1783\/revisions"}],"predecessor-version":[{"id":25781,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/1783\/revisions\/25781"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/448"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media?parent=1783"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}