{"id":1761,"date":"2019-09-17T22:53:58","date_gmt":"2019-09-17T20:53:58","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=1761"},"modified":"2023-06-21T09:51:15","modified_gmt":"2023-06-21T07:51:15","slug":"apoptosis-and-cancer","status":"publish","type":"page","link":"https:\/\/idibell.cat\/en\/research\/cancer-area\/molecular-mechanisms-and-experimental-therapy-in-oncology-program-oncobell\/apoptosis-and-cancer\/","title":{"rendered":"Apoptosis and Cancer"},"content":{"rendered":"\n

\n\t\tApoptosis and Cancer\n\t<\/h1>\n

\n\t\tSummary\n\t<\/h3>\n\t

The Apoptosis and Cancer group studies the mechanism of action of fluorizoline, a fluorate thiazoline compound, which is part of a new class of proapoptotic compounds and candidates to become anticancer agents, which have been discovered and reported by the group. The group also works towards evaluating the role of tumour stem cells in the therapeutic resistance of human glioblastoma and ovarian cancer at the cell and molecular mechanism level.<\/p>\n

232<\/h2>\n

Publications<\/h2>\n\t\t\t\t\"neuroblastoma_rosettes\"\n\t\t\t\t\tStrategic lines<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t\u2022 Induction mechanisms of apoptosis in cancer cells through the prohibitin-binding compound fluorizoline (Joan Gil)
\n\u2022 Study of the molecular bases of chemotherapy and radioresistance in gliobastoma and ovarian cancer (Avelina Tortosa and Pepita Gim\u00e9nez-Bonaf\u00e9)\n\t\t\t\t\t
Selected Publications<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t

Gonz\u00e1lez Vaca J, Hern\u00e1ndez MG, Cobo CS, Melendo Azuela EM, Tortosa Moreno I. Non-pharmacological interventions to reduce pain in dementia: A quasi-experimental study<\/strong>. Appl Nurs Res. 2022;63151546-151546. doi:10.1016\/j.apnr.2021.151546.<\/p>\n

Cabanillas Montferrer T, Gim\u00e9nez Bonaf\u00e9 P. El sesgo de g\u00e9nero en la asistencia sanitaria: definici\u00f3n, causas y consecuencias en los pacientes<\/strong>. MUSAS. 2022;7(1):106-129. doi:10.1344\/musas2022.vol7.num1.6.<\/p>\n

N\u00fa\u00f1ez V\u00e1zquez S, Saura Esteller J, S\u00e1nchez Vera I, Guilbaud E, Cosialls AM, Pons G, Ricci JE, Iglesias Serret D, Marchetti S, Gil J. The prohibitin-binding compound fluorizoline inhibits mitophagy in cancer cells<\/strong>. Oncogenesis. 2021;10(9):64-64. doi:10.1038\/s41389-021-00352-9.<\/p>\n

Saura Esteller J, Sanchez Vera I, Nunez Vazquez S, Cosialls AM, Gama Perez P, Bhosale G, Mendive Tapia L, Lavilla R, Pons G, Garcia Roves PM, Duchen MR, Iglesias Serret D, Gil J. Activation of the Integrated Stress Response and ER Stress Protect from Fluorizoline-Induced Apoptosis in HEK293T and U2OS Cell Lines<\/strong>. Int. J. Mol. Sci. 2021;22(11):doi:10.3390\/ijms22116117.<\/p>\n

Stanzani E, Pedrosa L, Bourmeau G, Anezo O, Noguera Castells A, Esteve Codina A, Passoni L, Matteoli M, de la Iglesia N, Seano G, Martinez Soler F, Tortosa A. Dual Role of Integrin Alpha-6 in Glioblastoma: Supporting Stemness in Proneural Stem-Like Cells While Inducing Radioresistance in Mesenchymal Stem-Like Cells<\/strong>. Cancers. 2021;13(12):doi:10.3390\/cancers13123055.<\/p>\n

 <\/p>\n\t\t\t\t\tSelected Projects<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t

– PID2020-120537RB-I00. Mecanismos de control de la apoptosis por prohibitina en c\u00e9lulas tumorales. Ministerio de Ciencia e Innovaci\u00f3n. IP: Joan Gil Santano. (Universitat de Barcelona). 01\/10\/2021-31\/9\/2024. 181.500 \u20ac.<\/p>\n

– PIFIISC19\/24. Desarrollo y evaluaci\u00f3n de una intervenci\u00f3n sobre Atenci\u00f3n Centrada en la Persona y Alfabetizaci\u00f3n Digital en Salud en C\u00e1ncer de Mama. Fundaci\u00f3n Canaria Instituto de Investigaci\u00f3n Sanitaria de Canarias (FIISC). IP: Yolanda Alvarez Perez. (Servicio de Evaluaci\u00f3n del Servicio Canario de la Salud). Participaci\u00f3: Pepita Gim\u00e9nez Bonaf\u00e9. 01\/01\/2020-31\/12\/2022. Import concedit: 17.419.61\u20ac.<\/p>\n

– Grup consolidat de l’AGAUR “Apoptosi i c\u00e1ncer”. IP: Joan Gil Santano<\/p>\n\t\t\t\t\tMore Information<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\tDoctoral Thesis:
\nSonia N\u00fa\u00f1ez-V\u00e1zquez.<\/strong> Molecular mechanisms of apoptosis induction and mitophagy inhibition by fluorizoline: tageting prohibitins as a new strategy for cancer treatment.<\/em> 2020
\nDepartment of Physiological Sciences
\nUniversity of Barcelona\n\t\t\t\t\"Joan-Gil-santano22\"\n

\n\t\tGil Santano, Joan\n\t<\/h4>\n

\n\t\t\n\t\tjgil@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n

\n\t\tPrincipal investigators\n\t<\/h2>\n\t\t\t\t\"Joan-Gil-santano22\"\n

\n\t\tGil Santano, Joan\n\t<\/h4>\n

\n\t\t\n\t\tjgil@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\"Pepita-Gimenez-Bonafe\"\n

\n\t\tGim\u00e9nez Bonafe, Pepita\n\t<\/h4>\n

\n\t\t\n\t\tpgimenez@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\"Avelina-Tortosa\"\n

\n\t\tTortosa Moreno, Avelina\n\t<\/h4>\n

\n\t\t\n\t\tatortosa@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\"Gabriel-Pons-Irazazabal\"\n

\n\t\tPons Irazaz\u00e1bal, Gabriel\n\t<\/h4>\n

\n\t\t\n\t\tgpons@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n

\n\t\tRELATED LINKS\n\t<\/h4>\n

\n\t\t\n\t\tDepartamento de Ciencias de la Salud – UB\n\t\t<\/a>\n\t<\/h4>\n

\n\t\t\n\t\tApored\n\t\t<\/a>\n\t<\/h4>\n

\n\t\t\n\t\t@AvelinaTortosa\n\t\t<\/a>\n\t<\/h4>\n

\n\t\tTeam\n\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\tGroup leaders\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPrincipal investigators \t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPostdoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tScientific support\t\t\t\t<\/a>\n\t\t\t\t\t\tGroup leaders\n\t\t\t\t\t\t\t\t\t\t\t