{"id":1761,"date":"2019-09-17T22:53:58","date_gmt":"2019-09-17T20:53:58","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=1761"},"modified":"2023-06-21T09:51:15","modified_gmt":"2023-06-21T07:51:15","slug":"apoptosis-and-cancer","status":"publish","type":"page","link":"https:\/\/idibell.cat\/en\/research\/cancer-area\/molecular-mechanisms-and-experimental-therapy-in-oncology-program-oncobell\/apoptosis-and-cancer\/","title":{"rendered":"Apoptosis and Cancer"},"content":{"rendered":"\n
The Apoptosis and Cancer group studies the mechanism of action of fluorizoline, a fluorate thiazoline compound, which is part of a new class of proapoptotic compounds and candidates to become anticancer agents, which have been discovered and reported by the group. The group also works towards evaluating the role of tumour stem cells in the therapeutic resistance of human glioblastoma and ovarian cancer at the cell and molecular mechanism level.<\/p>\n
Gonz\u00e1lez Vaca J, Hern\u00e1ndez MG, Cobo CS, Melendo Azuela EM, Tortosa Moreno I. Non-pharmacological interventions to reduce pain in dementia: A quasi-experimental study<\/strong>. Appl Nurs Res. 2022;63151546-151546. doi:10.1016\/j.apnr.2021.151546.<\/p>\n Cabanillas Montferrer T, Gim\u00e9nez Bonaf\u00e9 P. El sesgo de g\u00e9nero en la asistencia sanitaria: definici\u00f3n, causas y consecuencias en los pacientes<\/strong>. MUSAS. 2022;7(1):106-129. doi:10.1344\/musas2022.vol7.num1.6.<\/p>\n N\u00fa\u00f1ez V\u00e1zquez S, Saura Esteller J, S\u00e1nchez Vera I, Guilbaud E, Cosialls AM, Pons G, Ricci JE, Iglesias Serret D, Marchetti S, Gil J. The prohibitin-binding compound fluorizoline inhibits mitophagy in cancer cells<\/strong>. Oncogenesis. 2021;10(9):64-64. doi:10.1038\/s41389-021-00352-9.<\/p>\n Saura Esteller J, Sanchez Vera I, Nunez Vazquez S, Cosialls AM, Gama Perez P, Bhosale G, Mendive Tapia L, Lavilla R, Pons G, Garcia Roves PM, Duchen MR, Iglesias Serret D, Gil J. Activation of the Integrated Stress Response and ER Stress Protect from Fluorizoline-Induced Apoptosis in HEK293T and U2OS Cell Lines<\/strong>. Int. J. Mol. Sci. 2021;22(11):doi:10.3390\/ijms22116117.<\/p>\n Stanzani E, Pedrosa L, Bourmeau G, Anezo O, Noguera Castells A, Esteve Codina A, Passoni L, Matteoli M, de la Iglesia N, Seano G, Martinez Soler F, Tortosa A. Dual Role of Integrin Alpha-6 in Glioblastoma: Supporting Stemness in Proneural Stem-Like Cells While Inducing Radioresistance in Mesenchymal Stem-Like Cells<\/strong>. Cancers. 2021;13(12):doi:10.3390\/cancers13123055.<\/p>\n <\/p>\n\t\t\t\t\tSelected Projects<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t – PID2020-120537RB-I00. Mecanismos de control de la apoptosis por prohibitina en c\u00e9lulas tumorales. Ministerio de Ciencia e Innovaci\u00f3n. IP: Joan Gil Santano. (Universitat de Barcelona). 01\/10\/2021-31\/9\/2024. 181.500 \u20ac.<\/p>\n – PIFIISC19\/24. Desarrollo y evaluaci\u00f3n de una intervenci\u00f3n sobre Atenci\u00f3n Centrada en la Persona y Alfabetizaci\u00f3n Digital en Salud en C\u00e1ncer de Mama. Fundaci\u00f3n Canaria Instituto de Investigaci\u00f3n Sanitaria de Canarias (FIISC). IP: Yolanda Alvarez Perez. (Servicio de Evaluaci\u00f3n del Servicio Canario de la Salud). Participaci\u00f3: Pepita Gim\u00e9nez Bonaf\u00e9. 01\/01\/2020-31\/12\/2022. Import concedit: 17.419.61\u20ac.<\/p>\n – Grup consolidat de l’AGAUR “Apoptosi i c\u00e1ncer”. IP: Joan Gil Santano<\/p>\n\t\t\t\t\tMore Information<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\tDoctoral Thesis: Apoptosis and Cancer Summary The Apoptosis and Cancer group studies the mechanism of action of fluorizoline, a fluorate thiazoline compound, which is part of a new class of proapoptotic compounds and candidates to become anticancer agents, which have been discovered and reported by the group. The group also works towards evaluating the role of tumour […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":448,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"publishpress_future_action":{"enabled":false,"date":"2024-05-04 07:19:03","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/1761"}],"collection":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/comments?post=1761"}],"version-history":[{"count":5,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/1761\/revisions"}],"predecessor-version":[{"id":22748,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/1761\/revisions\/22748"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/448"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media?parent=1761"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nSonia N\u00fa\u00f1ez-V\u00e1zquez.<\/strong> Molecular mechanisms of apoptosis induction and mitophagy inhibition by fluorizoline: tageting prohibitins as a new strategy for cancer treatment.<\/em> 2020
\nDepartment of Physiological Sciences
\nUniversity of Barcelona\n\t\t\t\t\n\n\t\tGil Santano, Joan\n\t<\/h4>\n
\n\t\t\n\t\tjgil@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tPrincipal investigators\n\t<\/h2>\n\t\t\t\t\n
\n\t\tGil Santano, Joan\n\t<\/h4>\n
\n\t\t\n\t\tjgil@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tGim\u00e9nez Bonafe, Pepita\n\t<\/h4>\n
\n\t\t\n\t\tpgimenez@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tTortosa Moreno, Avelina\n\t<\/h4>\n
\n\t\t\n\t\tatortosa@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tPons Irazaz\u00e1bal, Gabriel\n\t<\/h4>\n
\n\t\t\n\t\tgpons@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tRELATED LINKS\n\t<\/h4>\n
\n\t\t\n\t\tDepartamento de Ciencias de la Salud – UB\n\t\t<\/a>\n\t<\/h4>\n
\n\t\t\n\t\tApored\n\t\t<\/a>\n\t<\/h4>\n
\n\t\t\n\t\t@AvelinaTortosa\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tTeam\n\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\tGroup leaders\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPrincipal investigators \t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tPostdoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tScientific support\t\t\t\t<\/a>\n\t\t\t\t\t\tGroup leaders\n\t\t\t\t\t\t\t\t\t\t\t
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\n\t\tRelated news\n\t<\/h2>\n\t\t\n\t\t\t\t<\/a>\n\t\t\tThe ability to inhibit mitophagy converts fluorizoline into a promising antitumor agent<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t07\/10\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tUB researchers synthetize a molecule that opens new pathways for cancer treatment and drug discovery<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t02\/10\/2014\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tResearcher Joan Gil wins Vald\u00e9s-Salas award in applied biomedicine<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t08\/06\/2011\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tMolecule Nutlin-3a activates a signal inducing cell death and senescence in primary brain tumors<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t20\/04\/2011\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tNew data validate effectiveness of a new treatment for leukaemia<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t04\/11\/2010\t\t\t\t\t\t\t\n\t\t\n\n","protected":false},"excerpt":{"rendered":"