{"id":17548,"date":"2021-06-30T08:07:23","date_gmt":"2021-06-30T06:07:23","guid":{"rendered":"https:\/\/idibell.cat\/en\/?page_id=17548"},"modified":"2024-06-03T14:29:46","modified_gmt":"2024-06-03T12:29:46","slug":"neurodevelopmental-disorders","status":"publish","type":"page","link":"https:\/\/idibell.cat\/en\/research\/neuroscience-area\/neuroscience-program\/neurodevelopmental-disorders\/","title":{"rendered":"Neurodevelopmental disorders"},"content":{"rendered":"\n<h1>\n\t\tNeurodevelopmental disorders\n\t<\/h1>\n<h3>\n\t\tSummary\n\t<\/h3>\n\t<p>The development of the central nervous system is strictly modulated by genetic and environmental factors in a spatial-temporal fashion. Even mild disturbances in genes and\/or environmental cues during critical periods of the pre- and post-natal development, lead to morphological and functional anomalies that will compromise the normal behaviour and cognitive function. By identifying risk factors and investigating their role in the central nervous system development, utilizing cutting-edge in vitro and in vivo technologies, we aim to design new and more effective strategies for therapeutic intervention.<\/p>\n<h2>85<\/h2>\n<h2>Publications<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2021\/06\/Neurodevelopmental-disorders2.jpg\" alt=\"Neurodevelopmental-disorders2\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"Neurodevelopmental-disorders2\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">Strategic lines<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\"><i>Expand<\/i><\/a>\n\t\t\t\t\t&#8211; Functional neurogenomics<br \/>\n&#8211; Biomimetic strategies for driving neural development and regeneration<br \/>\n&#8211; Human modeling of neurological disorders\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Selected Publications<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Alvarez,Z;Ortega,JA;Sato,K;Sasselli,IR;Kolberg Edelbrock,AN;Qiu,RM;Marshall,KA et al, <strong>Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons<\/strong>, Cell Stem Cell, 2023;30(2):219-doi:10.1016\/j.stem.2022.12.010<\/li>\n<li>SMITH, C. S., \u00c1LVAREZ, Z., QIU, R., SASSELLI, I. R., CLEMONS, T., ORTEGA, J. A., VILELA-PICOS, M., WELLMAN, H., KISKINIS, E. &amp; STUPP, S. I. 2023. <strong>Enhanced Neuron Growth and Electrical Activity by a Supramolecular Netrin-1 Mimetic Nanofiber<\/strong>. ACS Nano, 17, 19887-19902<\/li>\n<li>Ortega JA, Sasselli IR, Boccitto M, Fleming AC, Fortuna TR, Li Y, Sato K, Clemons TD, Mckenna ED, Nguyen TP, Anderson EN, Asin J, Ichida JK, Pandey UB, Wolin SL, Stupp SI, Kiskinis E. <strong>CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against C9ORF72 ALS\/FTD poly-GR pathophysiology<\/strong>. Sci Adv. 2023 Nov 10;9(45):eadf7997. doi: 10.1126\/sciadv.adf7997<\/li>\n<li>Musokhranova,U;Grau,C;Vergara,C;Rodr\u00edguez Pascau,L;Xiol,C;Castells,AA;Alc\u00e1ntara,S et al, <strong>Mitochondrial modulation with leriglitazone as a potential treatment for Rett syndrome<\/strong>., J. Transl. Med., 2023;21(1):756-756, doi:10.1186\/s12967-023-04622-5<\/li>\n<li>Garcia Gonzalez,L;Marti Sarrias,A;Puertas,MC;Bayon Gil,A;Resa Infante,P;Martinez Picado,J;Navarro,A et al, <strong>Understanding the neurological implications of acute and long COVID using brain organoids, Dis. Model<\/strong>. Mech., 2023;16(7):doi:10.1242\/dmm.050049<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Selected Projects<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>PUB22026. <strong>INVESTIGO 2022<\/strong>. SERVICIO PUBLICO DE EMPLEO ESTATAL SEPE. Budget: 66.217,68\u20ac. 2022 &#8211; . PI: Ortega Cano, Juan Alberto.<\/li>\n<li>INT23001. <strong>theALSmatrisome: Defining the contribution of ALS-associated alterations in motor neuron microenvironment to disease pathogenesis<\/strong>. ASSOCIATION FRAN\u00c7AISE CONTRE LES MYOPATHIES (FRENCH MUSCULAR DYSTROPHY ASSOCIATION) AFM-T\u00c9L\u00c9THON.\u00a0Budget: 30.000,00\u20ac. 2023-2025. PI: Ortega Cano, Juan Alberto.<\/li>\n<\/ul>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/11\/Soledad-Alcantara22-150x150.jpg\" alt=\"Soledad-Alcantara22\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Soledad-Alcantara22\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tAlc\u00e1ntara Horrillo, Soledad\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:salcantara@idibell.cat\" title=\"salcantara@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tsalcantara@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tPrincipal investigators\n\t<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/11\/Soledad-Alcantara22-150x150.jpg\" alt=\"Soledad-Alcantara22\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Soledad-Alcantara22\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tAlc\u00e1ntara Horrillo, Soledad\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:salcantara@idibell.cat\" title=\"salcantara@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tsalcantara@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2021\/06\/Sandra-Acosta-Verdugo-150x150.jpg\" alt=\"Sandra-Acosta-Verdugo\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Sandra-Acosta-Verdugo\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tAcosta Verdugo, Sandra\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2021\/06\/J-Alberto-Ortega-Cano-150x150.jpg\" alt=\"J-Alberto-Ortega-Cano\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"J-Alberto-Ortega-Cano\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tOrtega Cano, Alberto\n\t<\/h4>\n<h4>\n\t\tRELATED LINKS\n\t<\/h4>\n<h4>\n\t\t<a href=\"http:\/\/www.neurociencies.ub.edu\/neurodevelopmental-disorders\/\" title=\"Institute of Neurosciencies UB\" target=\"_blank\" rel=\"noopener\">\n\t\tInstitute of Neurosciencies UB\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/www.ub.edu\/portal\/web\/dp-patologia-terapeutica\/laboratori-de-desenvolupament-neural-ndlab-\" title=\"Soledad Alc\u00e1ntara - NDLab\" target=\"_blank\" rel=\"noopener\">\n\t\tSoledad Alc\u00e1ntara &#8211; NDLab\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"www.acostalab.cat\" title=\"Acosta Lab\" target=\"_blank\" rel=\"noopener\">\n\t\tAcosta Lab\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/sacostav\" title=\"@sacostav\" target=\"_blank\" rel=\"noopener\">\n\t\t@sacostav\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tTeam\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tGroup Leaders\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPrincipal Investigators\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPostdoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tPredoctoral researchers\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-4\" data-index=\"4\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-4\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tScientific support\t\t\t\t<\/a>\n\t\t\t\t\t\tGroup Leaders\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Alc\u00e1ntara Horrillo, Soledad<\/li>\n<\/ul>\n\t\t\t\t\t\tPrincipal Investigators\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Acosta Verdugo, Sandra<\/li>\n<li>Ortega Cano, Alberto<\/li>\n<\/ul>\n\t\t\t\t\t\tPostdoctoral researchers\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Garc\u00eda Gonz\u00e1lez, Laura<\/li>\n<\/ul>\n\t\t\t\t\t\tPredoctoral researchers\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Soriano Esque, Jos\u00e9 Pablo<\/li>\n<li>Soares de Aguiar, Gisele Priscila<\/li>\n<li>Mart\u00ed Sarrias, Andrea<\/li>\n<li>Turpin Moreno, Isabel<\/li>\n<\/ul>\n\t\t\t\t\t\tScientific support\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Cuenca Medina, Marta<\/li>\n<\/ul>\n<h2>\n\t\tRelated news\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/21412\" content=\"Organoids from the research group of Dr. Sandra Acosta exhibited at the CCCB exposition Cervells(s)\" \/><meta itemprop=\"datePublished\" content=\"2022-10-26\" \/><meta itemprop=\"dateModified\" content=\"2022-10-26\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/05\/Marca-B-e1651478109730.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\" \/><meta itemprop=\"name\" content=\"comunicacio\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/en\/wp-content\/uploads\/sites\/2\/2022\/10\/NO97-Expo-CCCB_Cervells-Imatge-noti.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2022\/10\/organoids-from-the-research-group-of-dr-sandra-acosta-exhibited-at-the-cccb-exposition-cervellss\/\" title=\"Organoids from the research group of Dr. Sandra Acosta exhibited at the CCCB exposition Cervells(s)\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/en\/2022\/10\/organoids-from-the-research-group-of-dr-sandra-acosta-exhibited-at-the-cccb-exposition-cervellss\/\" title=\"Organoids from the research group of Dr. Sandra Acosta exhibited at the CCCB exposition Cervells(s)\">Organoids from the research group of Dr. Sandra Acosta exhibited at the CCCB exposition Cervells(s)<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/en\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t26\/10\/2022\t\t\t\t\t\t\t\n\t\t<!-- .pp-content-posts -->\n\n","protected":false},"excerpt":{"rendered":"<p>Neurodevelopmental disorders Summary The development of the central nervous system is strictly modulated by genetic and environmental factors in a spatial-temporal fashion. Even mild disturbances in genes and\/or environmental cues during critical periods of the pre- and post-natal development, lead to morphological and functional anomalies that will compromise the normal behaviour and cognitive function. By [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":503,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-17548","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2024-12-25 08:41:30","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/17548","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/comments?post=17548"}],"version-history":[{"count":8,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/17548\/revisions"}],"predecessor-version":[{"id":24212,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/17548\/revisions\/24212"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/pages\/503"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media?parent=17548"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}