How do tumor cells exploit the microenvironment to promote cancer progression? Over the last decades, our understanding of cancer has undeniably evolved from a tumor cell centric view towards a more comprehensive \u201ctissue-like\u201d picture integrating extrinsic cues from the surrounding tumor microenvironment (TME) to shape a local ecosystem that favors the acquisition of the so called \u201challmarks of cancer\u201d. This has fueled the idea that deciphering the TME signals cancer cells rely on, could help unravel tumor vulnerabilities and pave the way to new treatment opportunities. These niche-dependencies do not follow a \u201cone size fits all\u201d pattern but are rather \u201cmade to tailor\u201d as they can be highly dependent on the cancer type, disease stage, organ site as well as dynamically evolving niche functions (e.g., due to ageing). The Medyouf lab is mapping and leveraging organ specific TME contributions that specifically hinder the early steps of the \u201ccancer immunity cycle\u201d thereby promoting immune evasion and limiting the therapeutic benefit of adaptive immune checkpoint therapies. The group is also actively exploring the impact of age-related niche changes on cancer evolution, to uncover new means for early disease interception and the rational design of new therapeutic combinations.<\/p>\n
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