{"id":24059,"date":"2024-05-15T08:30:40","date_gmt":"2024-05-15T06:30:40","guid":{"rendered":"https:\/\/idibell.cat\/en\/?post_type=agenda&#038;p=24059"},"modified":"2024-05-15T08:30:40","modified_gmt":"2024-05-15T06:30:40","slug":"idibellseminars-seeing-is-believing-visualising-the-heterogeneous-metabolism-of-breast-cancer","status":"publish","type":"agenda","link":"https:\/\/idibell.cat\/en\/agenda\/idibellseminars-seeing-is-believing-visualising-the-heterogeneous-metabolism-of-breast-cancer\/","title":{"rendered":"#IDIBELLseminars &#8211; Seeing is Believing: Visualising the Heterogeneous Metabolism of Breast Cancer"},"content":{"rendered":"<p>Tumours undergo constant Darwinian evolution and clonal diversification, the net result of which tends to be increased aggressiveness and invasiveness. These incipient clones can differ significantly in their metabolic needs, however the precise analysis thereof poses significant challenges due to the ephemeral nature of many metabolites and the fact that analysis is usually carried out in bulk. Using a suit of Mass Spectrometric Imaging techniques, we identify pantothenic acid (Vitamin B5) as a key metabolite required for tumour progression mediated by the oncogene Myc. Areas of high Myc expression showed increased pantothenic acid uptake, resulting in higher levels of CoA and increased Krebs cycle activity. Importantly, its deprivation reversed many of the metabolic changes mediated by Myc, and reduced tumour growth in both murine tumours as well as patient derived xenografts.<\/p>\n<p><em>Hosted by Andr\u00e9s M\u00e9ndez Lucas &#8211; Nutrition, metabolism and Gene Therapy group<\/em><\/p>\n","protected":false},"featured_media":24060,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"tags":[323],"class_list":["post-24059","agenda","type-agenda","status-publish","has-post-thumbnail","hentry","tag-translationalmedicine"],"_links":{"self":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/agenda\/24059"}],"collection":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/agenda"}],"about":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/types\/agenda"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media\/24060"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media?parent=24059"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/tags?post=24059"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}