{"id":21883,"date":"2023-02-09T09:24:35","date_gmt":"2023-02-09T08:24:35","guid":{"rendered":"https:\/\/idibell.cat\/en\/?post_type=agenda&#038;p=21883"},"modified":"2023-02-16T09:04:45","modified_gmt":"2023-02-16T08:04:45","slug":"idibellseminars-aging-vascular-dysfunction-at-the-driver-seat","status":"publish","type":"agenda","link":"https:\/\/idibell.cat\/en\/agenda\/idibellseminars-aging-vascular-dysfunction-at-the-driver-seat\/","title":{"rendered":"#IDIBELLseminars: Aging: vascular dysfunction at the driver seat"},"content":{"rendered":"<p>The increase in lifespan witnessed during the last century is unfortunately associated with more years of poor health since healthspan has not improved at the same rythm. Accordingly, current anti-aging interventions aim at delaying the onset of the age-associated diseases and frailties rather than further increasing life expectancy, by targeting age-related cellular pathways identified as \u201challmarks of aging\u201d. Aging manifests differently in our organs and functional deterioration occurs at different paces. Because our organs are interdependent, the deterioration of one usually affects others. But are they equal? We propose a hierarchy in organs aging and that vascular ageing is a critical upstream process driving the deterioration of many other organs. We provide evidence that VEGF-based vascular manipulation that negate ageing-associated microvascular rarefaction is, on its own, sufficient to confer a holistic geroprotection and to increase both lifespan and healthspan \u2026 in mice.<\/p>\n<p><em>Hosted by Carolina Florian, Stem Cell Aging Group<\/em><\/p>\n","protected":false},"featured_media":21884,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}}},"tags":[313],"_links":{"self":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/agenda\/21883"}],"collection":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/agenda"}],"about":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/types\/agenda"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media\/21884"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media?parent=21883"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/tags?post=21883"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}