{"id":16258,"date":"2021-04-06T08:20:10","date_gmt":"2021-04-06T06:20:10","guid":{"rendered":"https:\/\/idibell.cat\/en\/?post_type=agenda&#038;p=16258"},"modified":"2021-04-06T08:20:10","modified_gmt":"2021-04-06T06:20:10","slug":"idibellseminars-epigenetic-reprogramming-of-aging-repurposing-the-biology-of-reproduction-to-reverse-cellular-aging","status":"publish","type":"agenda","link":"https:\/\/idibell.cat\/en\/agenda\/idibellseminars-epigenetic-reprogramming-of-aging-repurposing-the-biology-of-reproduction-to-reverse-cellular-aging\/","title":{"rendered":"#IDIBELLseminars: Epigenetic reprogramming of aging: Repurposing the biology of reproduction to reverse cellular aging"},"content":{"rendered":"<p><strong>Vittorio Sebastiano<\/strong><br \/>\nStanford University, USA<\/p>\n<p>Aging is a complex biological phenomenon resulting in a wide number of distinct outcomes that include aberrant gene regulation, stem cell exhaustion, senescence, and deregulated cell\/tissue homeostasis. Whether these are caused by random and stochastic accumulation of \u201cerrors\u201d or by a species-specific developmental program, aging ultimately results in changes at the epigenetic level that impact cellular physiology and function. Seminal work in my lab has shown that a very tightly controlled and short exogenous expression of mRNAs encoding for OCT4, SOX2, KLF4, C-MYC, LIN-28 and NANOG (OSKMLN) results in a multifaceted reversal of cellular aging in human cells. We named this phenomenon epigenetic reprogramming of aging (ERA), and have consistently showed its efficacy in multiple human somatic and stem cells derived from elderly individuals by demonstrating that ERA affects all the hallmarks of aging with the exception of telomere elongation. Importantly, since we utilize non-integrative mRNAs and the cellular identity is not impacted, ERA could be a safe therapy for amelioration of aging phenotypes of entire tissues and organs. Our findings corroborate and enhance an increasing amount of evidence that transient expression of various combinations of the so called \u201cYamanaka factors\u201d promotes tissue regeneration and reversal of aging phenotypes in animal models. Collectively, this data strongly indicates that ERA is a powerful tool to promote cellular youthfulness and tissue regeneration with strong potential for application to any cell type in the body, thereby promoting tissue, systemic and organismal rejuvenation.<\/p>\n<p><em>Hosted by Carolina Florian<\/em><\/p>\n","protected":false},"featured_media":16259,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}}},"tags":[313],"_links":{"self":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/agenda\/16258"}],"collection":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/agenda"}],"about":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/types\/agenda"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media\/16259"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media?parent=16258"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/tags?post=16258"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}