• Determination of affinity constant (KD), kinetics: association and dissociation constants (kon, koff) in different models (protein-protein, protein-peptide, protein-small molecule, protein-RNA ...)
• Determination of effective concentration and quality control
• Antibody isotyping
• Screening of potential drugs/biosimilars
• Quantification of up to 50 biomarkers in biological fluids and samples in 96-well plate by Luminex
• Ultra-sensitive quantification of up to 4 biomarkers in biological fluids and samples in 96-well plate by SIMOA
• Measure of oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) in 96-well plate (Seahorse): mitohocondrial respiration, glycolysis, ATP production, lipolysis
• Fluorescent Scanning of several formats
• Set up and optimization of experimental conditions
• Scientific-technological support to researchers
• Training of new users in using the equipement

• Biacore T-200 (GE) for SPR analysis of interactions
• Seahorse XFe96 Analyzer (Agilent) for detection of OCR and ECAR in 96-well plate
• Magpix (Luminex) including xPonent 4.2 software for multiplex analysis of up to 50 magnetic beads
• SIMOA SR-X ultra-sensitive biomarker detection System (Quanterix)
• Fluorescence scanner Typhoon FLA9500 (GE) equipped with blue, green and red laser
• ImageQuant TL 7.0 software

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression. Peñuelas-Haro, I., Espinosa-Sotelo, R., Crosas-Molist, E., … Bertran, E. and Fabregat, I. Hepatology 2023, 78, 416-433. (agraïments Seahorse)

A novel family of lysosomotropic tetracyclic compounds for treating leukemia. Carbó, J.M., Cornet-Masana, J.M., .. and Risueño, R.M. Cancers 2023, 15, 1912 (agraïments Seahorse)

Dual and opposite costimulatory targeting with a novel human fusion recombinant protein effectively prevents renal warm ischemia reperfusion injury and allograft rejection in murine models. Guiteras, J, De Ramon, L., Crespo, E, Bolaños, N, Barceló-Batllori, S., et al. International Journal of Molecular Sciences, 2021, 22, 1216

Multi-laboratory experiment PME11 for the standardization of phosphoproteome analysis. Colomé, N., Abián, J., Aloria, K., Arizmendi, JM., Barceló-Batllori, S., et al. Journal of Proteomics, 2022, 251, 104409

Urinary cytokines reflect renal inflammation in acute tubulointerstitial nephritis: A multiplex bead-based assay assessment. Martinez Valenzulea, L., Draibe, J., Bestard, O., Fulladosa, X., et al. Journal of Clinical Medicine, 2021, 10, 2986 (agraïments Luminex)

Immunodominant proteins P1 and P40/P90 from human pathogen Mycoplasma pneumoniae. Vizarraga, D., Kawamoto, A., Matsumoto J, Illanes, R., Pérez-Luque, R., et al. Nature Communications, 2020, 11, 5188 (agraïments Biacore)

SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-kB pathway.
Santos-Barriopedro, I., Bosch-Presegué, L., Marazuela-Duque, A., de la Torre, C., Colomer, C., Vazquez, B.N., Fuhrmann, T., Martínez-Pastor, B., Lu, W., Braun, T., Bober, E., Jenuwein, T., Serrano, L., Esteller, M., Cheng, Z., Barceló-Batllori, S., Mostoslavsky, R., Espinosa, Ll., & Vaquero, A.
Nature communications, 2018, 9:101. doi: 10.1038/s41467-017-02586

KAT6B is a tumor suppressor histone H3 lysine 23 acetyltransferase undergoing genomic loss in small cell lung cancer.
Simó-Riudalbas, L., Pérez-Salvia, M., Setien F., Villanueva, A., Moutinho, C., Martínez-Cardús, A., Moran, S., Berdasco, M., Gomez, A., Vidal, E., Soler, M., Heyn, H., Vaquero, A., de la Torre, C., Barceló-Batllori S, … et Esteller, M
Cancer Research 2015, 75, 3936-3945

Integration of DIGE and bioinformatics analyses reveals a role of the anti-obesity agent tungstate in redox and energy homeostasis pathways in brown adipose tissue.
Barceló-Batllori, S., Esteban, Y. Moreno, S., Kalko, S. and Gomis, R.
Molecular and Cellular Proteomics, 2008, 7, 378-393