Neuropathology

Summary

The Neuropathology research group focusses on identifying new brain pathways, networks and clusters which change with age and in the initial stages of common neurodegenerative diseases, in order to understand the pathogenic factors which, occur during involution of the brain and in the initial stages of neurodegenerative diseases in old age, as well as identifying putative treatments for therapeutic prevention.

1161

Publications

Strategic lines

Selected Publications

Schmitz,M;Villar Piqué,A;Hermann,P;Escaramís,G;Calero,M;Chen,C;Kruse,N et al, Diagnostic accuracy of cerebrospinal fluid biomarkers in genetic prion diseases., Brain, 2022;145(2):700-712, doi:10.1093/brain/awab350

Hermann,P;Villar Piqué,A;Schmitz,M;Schmidt,C;Varges,D;Goebel,S;Bunck,T et al, Plasma Lipocalin 2 in Alzheimer's disease: potential utility in the differential diagnosis and relationship with other biomarkers., Alzheimers Res. Ther., 2022;14(1):9-9, doi:10.1186/s13195-021-00955-9

Ferrer,I, Hypothesis review: Alzheimer's overture guidelines., Brain Pathol., 2022;33(1):doi:10.1111/bpa.13122,

Parameswaran,J; Goicoechea,L;Planas Serra,L; Pastor,A; Ruiz,M; Calingasan,NY; Guilera,C et al, Activating cannabinoid receptor 2 preserves axonal health through GSK-3ß/NRF2 axis in adrenoleukodystrophy., Acta Neuropathol., 2022;144(2):241-258, doi:10.1007/s00401-022-02451-2

Thom,T;Schmitz,M;Fischer,AL;Correia,A;Correia,S;Llorens,F;Pique,AV et al, Cellular Prion Protein Mediates alpha-Synuclein Uptake, Localization, and Toxicity In Vitro and In Vivo, Mov Disord, 2022;37(1):39-51, doi:10.1002/mds.28774

Selected Projects

19PSJ012. Modulation of Tau seeding and pathology in tauopathies by BBB-nanocarriers, epitope selective vaccination and ectoPrP Tau receptor bodies. FUNDACIÓ "LA CAIXA". Budget: 312950. 2019-2022. PI: Ferrer Abizanda, Isidre.

20AGA001. Development and validation of new-generation fluid biomarker platforms for diagnosis, prognosis and disease monitoring of neurodegenerative dementias. Generalitat de Catalunya- Departament de Salut. Budget: 144300. 2020-2022. PI: Llorens Torres, Francesc.

20FIS023. Marcadores epigenéticos en depresión mayor: Efectos en fenotipos neurocognitivos, la evolución clínica y la resistencia terapeútica. Instituto de Salud Carlos III (ISCIII). Budget: 93170. 2020-2024. PI: Soria Tomas, Virginia; Barrachina Castillo, Marta.

Technology transfer

More Information

PROJECTS

Title: Modulation of Tau seeding and pathology in tauopathies by BBB-nanocarriers, epitope selective vaccination and ectoPrP Tau receptor bodies
PI: Ferrer Abizanda, Isidre
Coordinator: Institut de Bioenginyeria de Catalunya - IBEC (Project Leader: Dr. José Antonio Del Río Fernández)
Call reference Health Research 2018 Call for proposals, expediente: HR18-00452
Funder: Fundació “la Caixa”

Proyectos financiados por el Instituto de Salud Carlos III (ISCIII) y cofinanciados por el Fondo Europeo de Desarrollo Regional (FEDER):

Interactomas y marcadores para discriminar factores de vulnerabilidad neuronal regional en la neurodegeneración asociada al envejecimiento normal y patológico en el SNC

PI14/00757. 01/2015-12/2017. 152.000 €. IP: Isidre Ferrer Abizanda.

Análisis de las modificaciones en epigenomas, transcriptomas y proteomas en regiones cerebrales seleccionadas por su variable grado de vulnerabilidad de individuos de edades entre 35 y 75 años para identificar cambios degenerativos relacionados con envejecimiento normal y envejecimiento patológico. Identificación dirigida de proteínas como marcadores en el líquido cefalorraquídeo de los mismos individuos. Identificación de posibles dianas de terapias preventivas y análisis de tratamientos en modelos murinos.

Epigenetic and environmental factors bracing cognitive impairment and late-onset depression in elderly and early stages of Alzheimer disease

PIE14/00034. 01/2015-05/2019. 550.000 €. IP: Isidre Ferrer Abizanda.

Late-onset depression and cognitive impairment are very common in the elderly and cause a great deal of misery, in addition to representing a social and economic concern. Many of these individuals develop dementia of Alzheimer type and there is the suspicion that late-depression and mild cognitive impairment are linked by the same pathogenic process. The present project plans to study epigenetic, transcriptomic, proteomic, metabolomic, and bioinformatic systems processing in individual neurons and astrocytes obtained by laser microdissection of the locus coeruleus in cases with and without early Alzheimer’s disease-related pathology, and also their effects in the projection areas of the hippocampus and caudate putamen in the same cases.