Neurodevelopmental disorders

Summary

The development of the central nervous system is strictly modulated by genetic and environmental factors in a spatial-temporal fashion. Even mild disturbances in genes and/or environmental cues during critical periods of the pre- and post-natal development, lead to morphological and functional anomalies that will compromise the normal behaviour and cognitive function. By identifying risk factors and investigating their role in the central nervous system development, utilizing cutting-edge in vitro and in vivo technologies, we aim to design new and more effective strategies for therapeutic intervention.

85 Publications

Strategic lines

Selected Publications

Alvarez,Z;Ortega,JA;Sato,K;Sasselli,IR;Kolberg Edelbrock,AN;Qiu,RM;Marshall,KA et al, Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons, Cell Stem Cell, 2023;30(2):219-doi:10.1016/j.stem.2022.12.010
SMITH, C. S., ÁLVAREZ, Z., QIU, R., SASSELLI, I. R., CLEMONS, T., ORTEGA, J. A., VILELA-PICOS, M., WELLMAN, H., KISKINIS, E. & STUPP, S. I. 2023. Enhanced Neuron Growth and Electrical Activity by a Supramolecular Netrin-1 Mimetic Nanofiber. ACS Nano, 17, 19887-19902
Ortega JA, Sasselli IR, Boccitto M, Fleming AC, Fortuna TR, Li Y, Sato K, Clemons TD, Mckenna ED, Nguyen TP, Anderson EN, Asin J, Ichida JK, Pandey UB, Wolin SL, Stupp SI, Kiskinis E. CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against C9ORF72 ALS/FTD poly-GR pathophysiology. Sci Adv. 2023 Nov 10;9(45):eadf7997. doi: 10.1126/sciadv.adf7997
Musokhranova,U;Grau,C;Vergara,C;Rodríguez Pascau,L;Xiol,C;Castells,AA;Alcántara,S et al, Mitochondrial modulation with leriglitazone as a potential treatment for Rett syndrome., J. Transl. Med., 2023;21(1):756-756, doi:10.1186/s12967-023-04622-5
Garcia Gonzalez,L;Marti Sarrias,A;Puertas,MC;Bayon Gil,A;Resa Infante,P;Martinez Picado,J;Navarro,A et al, Understanding the neurological implications of acute and long COVID using brain organoids, Dis. Model. Mech., 2023;16(7):doi:10.1242/dmm.050049

Selected Projects

PUB22026. INVESTIGO 2022. SERVICIO PUBLICO DE EMPLEO ESTATAL SEPE. Budget: 66.217,68€. 2022 - . PI: Ortega Cano, Juan Alberto.
INT23001. theALSmatrisome: Defining the contribution of ALS-associated alterations in motor neuron microenvironment to disease pathogenesis. ASSOCIATION FRANÇAISE CONTRE LES MYOPATHIES (FRENCH MUSCULAR DYSTROPHY ASSOCIATION) AFM-TÉLÉTHON. Budget: 30.000,00€. 2023-2025. PI: Ortega Cano, Juan Alberto.