Head and neck diseases

• Recurrent respiratory papillomatosis. etiologic, clinic and treatment aspects, vaccine effects on the evolution and control of this desease.
• The new era of ear surgery : endoscopic ear surgery, safe techniques and results.
• Impacts of body composition in head and neck cancer
• New techniques for the surgical management of hereditary hemorragic telangiectasia (rendu-osler-weber disease)
• The effects of biologic treatments in chronic rhinosinusitis with polyposis.
• Radiomics and head and neck tumors
• The implementation of artificial intelligence in the diagnosis and management of head and neck tumors
• CT evaluation of sinonasal anatomy to improve the results and safeness of functional endoscopic sinonasal surgery
• Robotic surgery implementation and results in head and nceck cancer
• HPV and head and neck cancer

Haddad,RI;Harrington,K;Tahara,M;Ferris,RL;Gillison,M;Fayette,J;Daste,A et al, Nivolumab Plus Ipilimumab Versus EXTREME Regimen as First-Line Treatment for Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck: The Final Results of CheckMate 651., J. Clin. Oncol., 2022;doi:10.1200/JCO.22.00332,

Salawu,A;Hernando Calvo,A;Chen,RY;Araujo,DV;Oliva,M;Liu,ZA;Siu,LL, Impact of pharmacodynamic biomarkers in immuno-oncology phase 1 clinical trials., Eur. J. Cancer, 2022;173167-177, doi:10.1016/j.ejca.2022.06.045,

Hernando Calvo,A;Salawu,A;Chen,RY;Araujo,DV;Oliva,M;Liu,ZA;Siu,LL, A risk stratification model for toxicities in phase 1 immunotherapy trials., Eur. J. Cancer, 2022;17511-18, doi:10.1016/j.ejca.2022.08.003,

Arribas,L;Sabaté Llobera,A;Domingo,MC;Taberna,M;Sospedra,M;Martin,L;González Tampán,AR et al, Assessing dynamic change in muscle during treatment of patients with cancer: Precision testing standards., Clin. Nutr., 2022;41(5):1059-1065, doi:10.1016/j.clnu.2022.03.016,

Pons Escoda,A;Garcia Ruiz,A;Naval Baudin,P;Grussu,F;Fernandez,JJS;Simo,AC;Sarro,NV et al, Voxel-level analysis of normalized DSC-PWI time-intensity curves: a potential generalizable approach and its proof of concept in discriminating glioblastoma and metastasis., Eur Radiol, 2022;32(6):3705-3715, doi:10.1007/s00330-021-08498-1,

20ACL093. A RANDOMIZED, DOUBLE-BLIND, ADAPTIVE, PHASE II/III STUDY OF GSK3359609 OR PLACEBO IN COMBINATION WITH PEMBROLIZUMAB FOR FIRST-LINE TREATMENT OF PD-L1 POSITIVE RECURRENT/METASTATIC HEAD AND NECK SQUAMOUS CELL CARCINOMA. Budget: 236335,84. 2020- . PI: Plana Serrahima, María.

21ACL104. A RANDOMIZED, DOUBLE-BLIND PLACEBOCONTROLLED, PHASE 3 STUDY OF DEBIO 1143 IN COMBINATION WITH PLATINUM-BASED CHEMOTHERAPY AND STANDARD FRACTIONATION INTENSITY-MODULATED RADIOTHERAPY IN PATIENTS WITH LOCALLY ADVANCED SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK, SUITABLE FOR DEFINITIVE CHEMORADIOTHERAPY (TRILYNX). Budget: 173660,76. 2021- . PI: Oliva Bernal, Marc.

2022-232-1. A Phase 1 Study of SGN-PDL1V in Advanced Solid Tumors. Seagen Inc. Budget: 171306,45. 2022- . PI: Oliva Bernal, Marc.

20ACL181. ESTUDIO DE FASE II, ABIERTO Y MULTICÉNTRICO DE AL101 EN PACIENTES CON CARCINOMA ADENOIDE QUÍSTICO (ACC) CON MUTACIONES ACTIVADORAS NOTCH. Budget: 97497. 2020- . PI: Oliva Bernal, Marc.

PSJ22006. MoleculaR profiling and ImmunophEnotyping as preDictors of outcomE in non-metastatic SalIvary Gland carciNomas (REDESIGN). Grupo Español de Tratamiento de Tumores de Cabeza y Cuello (TTCC). Budget: 80000. 2022-2024. PI: Oliva Bernal, Marc.

Other Research Lines: The role of HPV on benign nasal disorders; TC evaluation of nasosinusal anatomy and its surgical implications; Genetic disorder and surgical treatment for patients with Rendu Osler Weber disease; Impact of body composition in head and neck cancer oncospecific treatments.