Colorectal Cancer

Molecular characterisation of gastrointestinal tumours through genomic, transcriptomic and proteomic analysis (R. Salazar, V. Moreno).
Construction of molecular signatures for predicting colorectal cancer prognosis (R. Salazar).
Predictions of therapeutic response based on molecular tumour detection and subtype classification (R. Salazar)
New experimental therapeutic strategies to overcome resistance in colorectal cancer treatment (R. Salazar).
Research, evaluation and validation of new diagnostic biomarkers in colorectal cancer (V. Moreno).
Genetic and epigenetic determinants of susceptibility to CRC and chemotherapy toxicity (V. Moreno).
Improvement in cancer precision medication and biomarker identification using computational analysis and large-scale integration of molecular data. (X. Solé).
Stratification of CRC patients based on molecular characteristics and the level of immune-cell infiltration of their tumours (R. Sanz-Pamplona).
Microbiome-host interactions and colorectal cancer (V. Pimenoff, M. Obon, V. Moreno)

Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk

Thomas, Minta; Sakoda, Lori C.; Hoffmeister, Michael; Rosenthal, Elisabeth A.; Lee, Jeffrey K.; van Duijnhoven, Franzel J. B.; Platz, Elizabeth A.; Wu, Anna H.; Dampier, Christopher H.; de la Chapelle, Albert; Wolk, Alicja; Joshi, Amit D.; Burnett-Hartman, Andrea; Gsur, Andrea; Lindblom, Annika; Castells, Antoni; Win, Aung Ko; Namjou, Bahram; Van Guelpen, Bethany; Tangen, Catherine M.; He, Qianchuan; Li, Christopher, I; Schafmayer, Clemens; Joshu, Corinne E.; Ulrich, Cornelia M.; Bishop, D. Timothy; Buchanan, Daniel D.; Schaid, Daniel; Drew, David A.; Muller, David C.; Duggan, David; Crosslin, David R.; Albanes, Demetrius; Giovannucci, Edward L.; Larson, Eric; Qu, Flora; Mentch, Frank; Giles, Graham G.; Hakonarson, Hakon; Hampel, Heather; Stanaway, Ian B.; Figueiredo, Jane C.; Huyghe, Jeroen R.; Minnier, Jessica; Chang-Claude, Jenny; Hampe, Jochen; Harley, John B.; Visvanathan, Kala; Curtis, Keith R.; Offit, Kenneth; Li, Li; Le Marchand, Loic; Vodickova, Ludmila; Gunter, Marc J.; Jenkins, Mark A.; Slattery, Martha L.; Lemire, Mathieu; Woods, Michael O.; Song, Mingyang; Murphy, Neil; Lindor, Noralane M.; Dikilitas, Ozan; Pharoah, Paul D. P.; Campbell, Peter T.; Newcomb, Polly A.; Milne, Roger L.; MacInnis, Robert J.; Castellvi-Bel, Sergi; Ogino, Shuji; Berndt, Sonja, I; Bezieau, Stephane; Thibodeau, Stephen N.; Gallinger, Steven J.; Zaidi, Syed H.; Harrison, Tabitha A.; Keku, Temitope O.; Hudson, Thomas J.; Vymetalkova, Veronika; Moreno, Victor; Martin, Vicente; Arndt, Volker; Wei, Wei-Qi; Chung, Wendy; Su, Yu-Ru; Hayes, Richard B.; White, Emily; Vodicka, Pavel; Casey, Graham; Gruber, Stephen B.; Schoen, Robert E.; Chan, Andrew T.; Potter, John D.; Brenner, Hermann; Jarvik, Gail P.; Corley, Douglas A.; Peters, Ulrike; Hsu, Li
AMERICAN JOURNAL OF HUMAN GENETICS. 2020, doi: 10.1016/j.ajhg.2020.07.006

Lymphocytic infiltration in stage II microsatellite stable colorectal tumors: A retrospective prognosis biomarker analysis

Sanz-Pamplona, Rebeca; Melas, Marilena; Maoz, Asaf; Schmit, Stephanie L.; Rennert, Hedy; Lejbkowicz, Flavio; Greenson, Joel K.; Sanjuan, Xavier; Lopez-Zambrano, Maria; Henar Alonso, M.; Qu, Chenxu; McDonnell, Kevin J.; Idos, Gregory E.; Vignali, Marissa; Emerson, Ryan; Fields, Paul; Guino, Elisabet; Santos, Cristina; Salazar, Ramon; Robins, Harlan S.; Rennert, Gad; Gruber, Stephen B.; Moreno, Victor
PLOS MEDICINE. 2020, doi: 10.1371/journal.pmed.1003292

Risk of colorectal cancer in users of bisphosphonates: analysis of population-based electronic health records

Ibanez-Sanz, Gemma; Guino, Elisabet; Pontes, Caridad; Morros, Rosa; de la Pena-Negro, Luisa C.; Angeles Quijada-Manuitt, Ma; Moreno, Victor
EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2020, doi: 10.1007/s10654-019-00584-5

Genomewide Association Study of Severe Covid-19 with Respiratory Failure

Ellinghaus, David; Degenhardt, Frauke; Bujanda, Luis; Buti, Maria; Albillos, Agustin; Invernizzi, Pietro; Fernandez, Javier; Prati, Daniele; Baselli, Guido; Asselta, Rosanna; Grimsrud, Marit M.; Milani, Chiara; Aziz, Fatima; Kassens, Jan; May, Sandra; Wendorff, Mareike; Wienbrandt, Lars; Uellendahl-Werth, Florian; Zheng, Tenghao; Yi, Xiaoli; de Pablo, Raul; Chercoles, Adolfo G.; Palom, Adriana; Garcia-Fernandez, Alba-Estela; Rodriguez-Frias, Francisco; Zanella, Alberto; Bandera, Alessandra; Protti, Alessandro; Aghemo, Alessio; Lleo, Ana; Biondi, Andrea; Caballero-Garralda, Andrea; Gori, Andrea; Tanck, Anja; Nolla, Anna Carreras; Latiano, Anna; Fracanzani, Anna Ludovica; Peschuck, Anna; Julia, Antonio; Pesenti, Antonio; Voza, Antonio; Jimenez, David; Mateos, Beatriz; Jimenez, Beatriz Nafria; Quereda, Carmen; Paccapelo, Cinzia; Gassner, Christoph; Angelini, Claudio; Cea, Cristina; Solier, Aurora; Pestana, David; Muniz-Diaz, Eduardo; Sandoval, Elena; Paraboschi, Elvezia M.; Navas, Enrique; Sanchez, Felix Garcia; Ceriotti, Ferruccio; Martinelli-Boneschi, Filippo; Peyvandi, Flora; Blasi, Francesco; Tellez, Luis; Blanco-Grau, Albert; Hemmrich-Stanisak, Georg; Grasselli, Giacomo; Costantino, Giorgio; Cardamone, Giulia; Foti, Giuseppe; Aneli, Serena; Kurihara, Hayato; ElAbd, Hesham; My, Ilaria; Galvan-Femenia, Ivan; Martin, Javier; Erdmann, Jeanette; Ferrusquia-Acosta, Jose; Garcia-Etxebarria, Koldo; Izquierdo-Sanchez, Laura; Bettini, Laura R.; Sumoy, Lauro; Terranova, Leonardo; Moreira, Leticia; Santoro, Luigi; Scudeller, Luigia; Mesonero, Francisco; Roade, Luisa; Ruhlemann, Malte C.; Schaefer, Marco; Carrabba, Maria; Riveiro-Barciela, Mar; Basso, Maria E. Figuera; Valsecchi, Maria G.; Hernandez-Tejero, Maria; Acosta-Herrera, Marialbert; D'Angio, Mariella; Baldini, Marina; Cazzaniga, Marina; Schulzky, Martin; Cecconi, Maurizio; Wittig, Michael; Ciccarelli, Michele; Rodriguez-Gandia, Miguel; Bocciolone, Monica; Miozzo, Monica; Montano, Nicola; Braun, Nicole; Sacchi, Nicoletta; Martinez, Nilda; Ozer, Onur; Palmieri, Orazio; Faverio, Paola; Preatoni, Paoletta; Bonfanti, Paolo; Omodei, Paolo; Tentorio, Paolo; Castro, Pedro; Rodrigues, Pedro M.; Blandino, Aaron; de Cid, Rafael; Ferrer, Ricard; Gualtierotti, Roberta; Nieto, Rosa; Goerg, Siegfried; Badalamenti, Salvatore; Marsal, Sara; Matullo, Giuseppe; Pelusi, Serena; Juzenas, Simonas; Aliberti, Stefano; Monzani, Valter; Moreno, Victor; Wesse, Tanja; Lenz, Tobias L.; Pumarola, Tomas; Rimoldi, Valeria; Bosari, Silvano; Albrecht, Wolfgang; Peter, Wolfgang; Romero-Gomez, Manuel; D'Amato, Mauro; Duga, Stefano; Banales, Jesus M.; Hov, Johannes R.; Folseraas, Trine; Valenti, Luca; Franke, Andre; Karlsen, Tom H.
NEW ENGLAND JOURNAL OF MEDICINE. 2020, doi: 10.1056/NEJMoa2020283

Clinical Portrait of the SARS-CoV-2 Epidemic in European Patients with Cancer

Pinato, David J.; Zambelli, Alberto; Aguilar-Company, Juan; Bower, Mark; Sng, Christopher C. T.; Salazar, Ramon; Bertuzzi, Alexia; Brunet, Joan; Mesia, Ricard; Segui, Elia; Biello, Federica; Generali, Daniele; Grisanti, Salvatore; Rizzo, Gianpiero; Libertini, Michela; Maconi, Antonio; Harbeck, Nadia; Vincenzi, Bruno; Bertulli, Rossella; Ottaviani, Diego; Carbo, Anna; Bruna, Riccardo; Benafif, Sarah; Marrari, Andrea; Wuerstlein, Rachel; Carmona-Garcia, M. Carmen; Chopra, Neha; Tondini, Carlo; Mirallas, Oriol; Tovazzi, Valeria; Betti, Marta; Provenzano, Salvatore; Fotia, Vittoria; Cruz, Claudia Andrea; Dalla Pria, Alessia; D'Avanzo, Francesca; Evans, Joanne S.; Saoudi-Gonzalez, Nadia; Felip, Eudald; Galazi, Myria; Garcia-Fructuoso, Isabel; Lee, Alvin J. X.; Newsom-Davis, Thomas; Patriarca, Andrea; Garcia-Illescas, David; Reyes, Roxana; Dileo, Palma; Sharkey, Rachel; Wong, Yien Ning Sophia; Ferrante, Daniela; Marco-Hernandez, Javier; Sureda, Anna; Maluquer, Clara; Ruiz-Camps, Isabel; Gaidano, Gianluca; Rimassa, Lorenza; Chiudinelli, Lorenzo; Izuzquiza, Macarena; Cabirta, Alba; Franchi, Michela; Santoro, Armando; Prat, Aleix; Tabernero, Josep; Gennari, Alessandra

CANCER DISCOVERY. 2020, doi: 10.1158/2159-8290.CD-20-0773

Personalised surveillance for serrated polyposis syndrome: results from a prospective 5-year international cohort study

Bleijenberg, Arne G. C.; IJspeert, Joep E. G.; van Herwaarden, Yasmijn J.; Carballal, Sabela; Pellise, Maria; Jung, Gerhard; Bisseling, Tanya M.; Nagetaal, Iris D.; van Leerdam, Monique E.; van Lelyveld, Niels; Bessa, Xavier; Rodriguez-Moranta, Francisco; Bastiaansen, Barbara; de Klaver, Willemijn; Rivero, Liseth; Spaander, Manon C. W.; Koornstra, Jan Jacob; Bujanda, Luis; Balaguer, Francesc; Dekker, Evelien

GUT 19,819. 2020, doi: 10.1136/gutjnl-2018-318134

Genetic and metabolomics screening towards the precision medicine in cancer prevention

Moreno Aguado, Victor Raul (Principal investigator (PI))

Funder:

• ASOCIACION ESPAÑOLA CONTRA EL CANCER

2018-2023

New therapeutic strategies for resistant colorectal cancer

Salazar Soler, Ramon (Principal investigator (PI))

Funder:

• ASOCIACION ESPAÑOLA CONTRA EL CANCER

2015-2022

Estudio de las interacciones microbioma-anfitrión para la prevención del cáncer colorrectal (Colonbiome)

Moreno Aguado, Victor Raul (Principal investigator (PI))

Funder reference:

• FIS-Instituto de Salud Carlos III

2018-2022

Using functional genomics to inform gene environment interactions for colorectal cancer

Moreno Aguado, Victor Raul (Principal investigator (PI))

Funder:

• FRED HUTCHINSON CANCER RESEARCH CENTER

2016-2021

Refining the consensus molecular subtypes classification: prognostic and therapeutic implications in stage II colon cancer.

Salazar Soler, Ramon (Principal investigator (PI))

Funder:

• FIS-Instituto de Salud Carlos III

2020-2022

MECoCaM:Human gut Microbiome, gene Expression and Colorectal Cancer: Assigning causal roles from a novel Mendelian randomization perspective

Carreras Torres, Robert (Principal investigator (PI))

Funder:

• COMUNITAT EUROPEA

2018-2020

METODO PARA DETERMINAR EL RIESGO DE DESARROLLAR METASTASIS CEREBRAL Y UN KIT PARA LLEVAR A CABO DICHO PROCEDIMIENTO

SANZ PAMPLONA REBECA (Inventores-as/autores-as/obtentores-as); SIERRA JIMENEZ ANGELS (Inventores-as/autores-as/obtentores-as); OLIVA MIGUEL BALDOMERO (Inventores-as/autores-as/obtentores-as); MORENO AGUADO VICTOR RAUL (Inventores-as/autores-as/obtentores-as); GIL GIL JUAN MIGUEL (Inventores-as/autores-as/obtentores-as)

METHOD FOR DETERMINING THE RISK OF DEVELOPING BRAIN METASTASIS, AND A KIT TO CARRY OUT SAID METHOD

Sanz Pamplona, Rebeca (Inventores-as/autores-as/obtentores-as); SIERRA JIMENEZ, Angels (Inventores-as/autores-as/obtentores-as); OLIVA MIGUEL, Baldomero (Inventores-as/autores-as/obtentores-as); Moreno Aguado, Victor Raul (Inventores-as/autores-as/obtentores-as); Gil Gil, Juan Miguel (Inventores-as/autores-as/obtentores-as)

See full list

Participation in international consortiums: MOTRICOLOR (Molecularly guided trials with specific treatment strategies in patients with advanced newly molecular defined subtypes of colorectal cancer) and FIGI (Using functional genomics to inform gene environment interactions for CRC).
Colonomics as a platform for biomarker discovery and characterisation of CRC.
Clinical validation of ColoPrint®, a phase II prognostic genetic signature and new consensus on molecular subtype classification (CMS 1-4)