Apoptosis and Cancer

Summary

The Apoptosis and Cancer group studies the mechanism of action of fluorizoline, a fluorate thiazoline compound, which is part of a new class of proapoptotic compounds and candidates to become anticancer agents, which have been discovered and reported by the group. The group also works towards evaluating the role of tumour stem cells in the therapeutic resistance of human glioblastoma and ovarian cancer at the cell and molecular mechanism level.

232 Publications

Strategic lines

Selected Publications

GRP94 promotes brain metastasis by engaging pro-survival autophagy

Santana-Codina, Naiara; Muixi, Laia; Foj, Ruben; Sanz-Pamplona, Rebeca; Badia-Villanueva, Miriam; Abramowicz, Agata; Marce-Grau, Anna; Maria Cosialls, Ana; Gil, Joan; Archilla, Ivan; Pedrosa, Leire; Gonzalez, Josep; Aldecoa, Iban; Sierra, Angels

NEURO-ONCOLOGY. 2020, doi: 10.1093/neuonc/noz198

Lysosomal degradation ensures accurate chromosomal segregation to prevent chromosomal instability

Almacellas, Eugenia; Pelletier, Joffrey; Day, Charles; Ambrosio, Santiago; Tauler, Albert; Mauvezin, Caroline

AUTOPHAGY. 2020, doi: 10.1080/15548627.2020.1764727

The BCL-2 family members NOXA and BIM mediate fluorizoline-induced apoptosis in multiple myeloma cells

Cosialls, Ana M.; Sanchez-Vera, Ismael; Pomares, Helena; Perramon-Andujar, Judit; Sanchez-Esteban, Sandra; Palmeri, Claudia M.; Iglesias-Serret, Daniel; Saura-Esteller, Jose; Nunez-Vazquez, Sonia; Lavilla, Rodolfo; Gonzalez-Barca, Eva M.; Pons, Gabriel; Gil, Joan

BIOCHEMICAL PHARMACOLOGY. 2020, doi: 10.1016/j.bcp.2020.114198

NOXA upregulation by the prohibitin-binding compound fluorizoline is transcriptionally regulated by integrated stress response-induced ATF3 and ATF4

Nunez-Vazquez, Sonia; Sanchez-Vera, Ismael; Saura-Esteller, Jose; Cosialls, Ana M.; Noisier, Anais F. M.; Albericio, Fernando; Lavilla, Rodolfo; Pons, Gabriel; Iglesias-Serret, Daniel; Gil, Joan

FEBS JOURNAL. 2020, doi: 10.1111/febs.15480

Selected Projects