Pancreas Regeneration: Pancreatic Progenitors And Their Niche
Type 1 diabetes is caused by an autoimmune destruction of pancreatic β cells. These cells are the source of insulin, a hormone required for the regulation of blood glucose levels. One approach to recovering glucose homeostasis would be to induce restoration of β-cell mass, either by replacement with exogenous cells or by regeneration from endogenous progenitors, but the existence of such progenitors is still controversial. Rovira’s group is focused in the role of ductal cells as pancreatic progenitors in order to develop new therapies for diabetes treatment. On the other hand the lab is also studying the niche required for pancreatic progenitor maintenance.