Gene Regulation of Cell Identity Group
Hosted by Angel Raya
Single-cell transcriptomics has revolutionized the way we can study the dynamics of gene regulation and its impact in cell proliferation and differentiation. In a single-cell transcriptomics experiment, we sequence the gene repertoire of thousands of cells simultaneously. By comparing the transcriptomic profiles of all these cells computationally, we can capture the dynamics of any given cellular process and understand its dynamics.
In this talk, I will give a brief overview of several projects in which we have used single-cell transcriptomics to understand gene regulation at different levels including (1) how to perform a cell atlas and reconstruct computationally cellular lineage trees; (2) study the dynamics of post-transcriptional regulation during cell cycle progression; and (3) characterize the differentiation of mouse embryonic stem cells to neurons.
About the speaker
Dr. Mireya Plass studied a BS in Biology (2005) and holds a PhD in Health and Life Sciences (2011) from Pompeu Fabra University (Barcelona, Spain). She pursued postdoctoral training abroad first at the University of Copenhagen (Krogh Lab, 2011-2015) and later at the Berlin Institute for Medical Systems Biology (N. Rajewsky Lab, 2016-2019) before returning to Spain to complete her post-doctoral training at the Center for Genomic Regulation with a Marie Sklodowska-Curie Fellowship (Irimia Lab, 2019). In October 2019, she joined the CMRB as independent group leader.
Throughout her career, Dr. Plass has been interested in understanding how post-transcriptional regulatory mechanisms, such as splicing and alternative polyadenylation, shape gene expression from an evolutionary and systems biology perspective. Recently, her work has pioneered the use of single-cell transcriptomics to understand how gene expression drives cellular differentiation. As independent group leader, she wants to investigate the function of post-transcriptional regulation in gene expression and cell differentiation, and in particular its contribution to the development of neurodevelopmental and neurodegenerative diseases.