Hepato-biliary-pancreatic pathology

Summary

This group’s main area of interest is the study of diseases associated with the liver, in particular complications involving liver transplants, cirrhosis, hepatitis B and C, liver and pancreatic cancer.
The approach is mainly of a clinical nature, with patient studies and epidemiological (populational) studies on the characteristics that correlate with the prognoses, and the causes of treatment complications. The relevance of the group’s research is clear. On the one hand, pancreatic cancer has one of the worst prognoses due to it being difficult to diagnose, and on the other hand, due to the central position of the liver metabolism in the human body.

1344

Publications

Strategic lines

Selected Publications

Loras C, Andújar X, Gornals JB, Sanchiz V, Brullet E, Sicilia B, Martín Arranz MD, Naranjo A, Barrio J, Dueñas C, Foruny JR, Busquets D, Monfort D, Pineda JR, González Huix F, Pérez Roldán F, Pons V, González B, Reyes Moreno J, Sainz E, Guardiola J, Bosca Watts MM, Fernández Bañares F, Mayor V, Esteve M, Grupo Español de Trabajo de la Enfermedad de Crohn Colitis Ulcerosa (GETECCU) Y. Self-expandable metal stents versus endoscopic balloon dilation for the treatment of strictures in Crohn's disease (ProtDilat study): an open-label, multicentre, randomised trial. Lancet Gastroenterol. Hepatol. 2022;7(4):332-341. doi:10.1016/S2468-1253(21)00386-1.

Favà A, Donadeu L, Jouve T, Gonzalez Costello J, Lladó L, Santana C, Toapanta N, Lopez M, Pernin V, Facundo C, Cabañas NS, Thaunat O, Crespo M, Llinàs L, Revuelta I, Sabé N, Rombauts A, Calatayud L, Ardanuy C, Esperalba J, Fernandez C, Lozano JJ, Preyer R, Strecker K, Couceiro C, García Romero E, Cachero A, Meneghini M, Torija A, Le Quintrec M, Melilli E, Cruzado JM, Polo C, Moreso F, Crespo E, Bestard O. A comprehensive assessment of long-term SARS-CoV-2-specific adaptive immune memory in convalescent COVID-19 Solid Organ Transplant recipients. Kidney Int. 2022;101(5):1027-1038. doi:10.1016/j.kint.2021.12.029.

Riera Mestre A, Cerdà P, Guzmán YC, Iriarte A, Torroella A, Mora Luján JM, Castellote J, Hessheimer A, Fondevila C, Lladó L. Perioperative Complications and Long-Term Follow-Up of Liver Transplantation in Hemorrhagic Hereditary Telangiectasia: Report of Three Cases and Systematic Review. J. Clin. Med. 2022;11(19):doi:10.3390/jcm11195624.

Hessheimer AJ, de la Rosa G, Gastaca M, Ruíz P, Otero A, Gómez M, Alconchel F, Ramírez P, Bosca A, López Andújar R, Atutxa L, Royo Villanova M, Sánchez B, Santoyo J, Marín LM, Gómez Bravo MÁ, Mosteiro F, Villegas Herrera MT, Villar Del Moral J, González Abos C, Vidal B, López Domínguez J, Lladó L, Roldán J, Justo I, Jiménez C, López Monclús J, Sánchez Turrión V, Rodríguez Laíz G, Velasco Sánchez E, López Baena JÁ, Caralt M, Charco R, Tomé S, Varo E, Martí Cruchaga P, Rotellar F, Varona MA, Barrera M, Rodríguez Sanjuan JC, Briceño J, López D, Blanco G, Nuño J, Pacheco D, Coll E, Domínguez Gil B, Fondevila C. Abdominal normothermic regional perfusion in controlled donation after circulatory determination of death liver transplantation: Outcomes and risk factors for graft loss. Am. J. Transplant. 2022;22(4):1169-1181. doi:10.1111/ajt.16899.

Rudler M, Hernández Gea V, Procopet BD, Giráldez A, Amitrano L, Villanueva C, Ibañez L, Silva Junior G, Genesca J, Bureau C, Trebicka J, Bañares R, Krag A, Llop E, Laleman W, Palazon JM, Castellote J, Rodrigues S, Gluud LL, Noronha Ferreira C, Canete N, Rodríguez M, Ferlitsch A, Mundi JL, Gronbaek H, Hernandez Guerra M, Sassatelli R, Dell'era A, Senzolo M, Abraldes JG, Romero Gómez M, Zipprich A, Casas M, Masnou H, Larrue H, Primignani M, Nevens F, Calleja JL, Schwarzer R, Jansen C, Robic MA, Conejo I, Martínez Gonzalez J, Catalina MV, Albillos A, Alvarado E, Guardascione MA, Mallet M, Tripon S, Casanovas G, Bosch J, Garcia Pagan JC, Thabut D, for International Variceal Bleeding Observational Study Group: a Baveno Coopera . Hepatic encephalopathy is not a contraindication to pre-emptive TIPS in high-risk patients with cirrhosis with variceal bleeding. Gut. 2022;doi:10.1136/gutjnl-2022-326975. I

Selected Projects

18ACL021. EFECTOS SOBRE LA MORTALIDAD DE LA ADMINISTRACIÓN DE ALBÚMINA EN PACIENTES CON CIRROSIS Y ENCEFALOPATIA HEPÁTICA . Budget: 3475. 2018-2022. PI: Castellote Alonso, José.

19ACL227. ESTUDIO EN FASE II CON DOBLE ENMASCARAMIENTO, ALEATORIZADO DE GRUPOS PARALELOS PARA EVALUAR LA EFICACIA, LA SEGURIDAD Y LA TOLERABILIDAD DEL ÁCIDO OBETICÓLICO CUANDO SE ADMINISTRA EN COMBINACIÓN CON BEZAFIBRATO EN SUJETOS CON COLANGITIS BILIAR PRIMARIA QUE TUVIERON UNA RESPUESTA INSUFICIENTE AL ÁCIDO URSODESOXICÓLICO O QUE NO PUDIERON TOLERARLO . Budget: 48956,4. 2019-2022. PI: Castellote Alonso, José.

MAR21016. Functional Immune-Monitoring of Virus-specific T and B-cell Responses in Solid Organ Transplant Recipients receiving SARS-CoV-2 Vaccination (MoniToR). Fundació La Marató de TV3. Budget: 31250. 2021-2023. PI: Lladó Garriga, Laura.