Cellular and Molecular Neurobiology

Summary

The Cellular and Molecular Neurobiology group investigates the molecular mechanisms that control neurotransmission. We are interested in all aspects related to the cell biology of synapses, paying particular attention to events related to the trafficking of synaptic vesicles. The group has its origins in the use of toxins, particularly neurotoxins, to study cellular and tissular processes related to regulated secretion (neurotransmitters, hormones). Our findings have a broad translational interest and are particullarly relevant to synaptopathies, which are diseases that cause synaptic disfunctions and include, for example, autism spectrum disorder, schizophrenia or many neurodegenerative diseases.

349 Publications

Strategic lines

Selected Publications

Gao L, Meiring JCM, Varady A, Ruider IE, Heise C, Wranik M, Velasco CD, Taylor JA, Terni B, Weinert T, Standfuss J, Cabernard CC, Llobet A, Steinmetz MO, Bausch AR, Distel M, Thorn Seshold J, Akhmanova A, Thorn Seshold O. In Vivo Photocontrol of Microtubule Dynamics and Integrity, Migration and Mitosis, by the Potent GFP-Imaging-Compatible Photoswitchable Reagents SBTubA4P and SBTub2M. J Am Chem Soc. 2022;144(12):5614-5628. doi:10.1021/jacs.2c01020.
Terni B, Llobet A. Axon terminals control endolysosome diffusion to support synaptic remodelling. Life Sci Alliance. 2021;4(8):doi:10.26508/lsa.202101105.

Dorca Arévalo J, Gómez de Aranda I, Blasi J. New Mutants of Epsilon Toxin from Clostridium perfringens with an Altered Receptor-Binding Site and Cell-Type Specificity. Toxins (Basel). 2022;14(4):doi:10.3390/toxins14040288.

Ortiz Miguel S, Miguel Perez M, Navarro J, Moller I, Perez Bellmunt A, Agullo JL, Ortiz Sagrista J, Blasi J, Martinoli C. Compartments of the antebrachial fascia of the forearm: clinically relevant ultrasound, anatomical and histological findings. SURG RADIOL ANAT. 2021;43(10):1569-1579. doi:10.1007/s00276-021-02736-3.

Rodriguez Martinez A, Trapero C, Vidal A, Piulats JM, de Aranda IG, Sevigny J, Fernandez Montoli ME, Ponce J, Matias Guiu X, Martin Satue M. Characterization of the Endometrial MSC Marker Ectonucleoside Triphosphate Diphosphohydrolase-2 (NTPDase2/CD39L1) in Low- and High-Grade Endometrial Carcinomas: Loss of Stromal Expression in the Invasive Phenotypes. J Pers Med. 2021;11(5):doi:10.3390/jpm11050331.

Selected Projects