The grant will go thyroid abnormalities research in rare childhood diseases.
By studying the role of lysosomes in mitosis, an IDIBELL and UB group discovers that alterations in the separation of chromosomes cause a detectable nucleus morphology once mitosis has finished. This morphology would be useful to identify cells that have chromosomal instability inherent in cancer cells.
The study, published in the Nature Communications journal, and led by the Netherlands Cancer Institute (NKI), has had the collaboration of researchers from IDIBELL/ICO and HUB.
This study demonstrates the beneficial effect of treatment with a cocktail drug at low doses to block a single signaling pathway in a lung cancer type.
The study shows that the involvement of certain genes that predispose to cancer also affects the immune system, which could facilitate tumor growth.
In the specific case of breast cancer, the involvement of the SH2B3 gene, corresponding to a lymphocyte protein, increases the predisposition to develop cancer.