Apoptosis and cancer

Summary

The Apoptosis and Cancer group studies the mechanism of action of fluorizoline, a fluorate thiazoline compound, which is part of a new class of proapoptotic compounds and candidates to become anticancer agents, which have been discovered and reported by the group. The group also works towards evaluating the role of tumour stem cells in the therapeutic resistance of human glioblastoma and ovarian cancer at the cell and molecular mechanism level.

232 Publications

Strategic lines

Selected Publications

Espinosa Sotelo,R;Fuste,NP;Penuelas Haro,I;Alay,A;Pons,G;Almodovar,X;Albaladejo,J et al, Dissecting the role of the NADPH oxidase NOX4 in TGF-beta signaling in hepatocellular carcinoma, Redox Biol., 2023;65102818-102818, doi:10.1016/j.redox.2023.102818
Pedrosa,L;Bedia,C;Diao,DL;Mosteiro,A;Ferres,A;Stanzani,E;Martinez Soler,F et al, Preclinical Studies with Glioblastoma Brain Organoid Co-Cultures Show Efficient 5-ALA Photodynamic Therapy, Cells, 2023;12(8):doi:10.3390/cells12081125
Sánchez Vera,I;Saura Esteller,J;Núñez Vázquez,S;Cosialls,AM;Ghashghaei,O;Lavilla,R;Pons,G et al, The prohibitin-binding compound fluorizoline induces the pro-inflammatory cytokines interleukin-8 and interleukin-6 through the activation of JNK and p38 MAP kinases, Biochem. Pharmacol., 2023;218115860-115860, doi:10.1016/j.bcp.2023.115860
Sanchez Vera,I;Nunez Vazquez,S;Saura Esteller,J;Cosialls,AM;Heib,J;Rodriguez,PN;Ghashghaei,O et al, The Prohibitin-Binding Compound Fluorizoline Activates the Integrated Stress Response through the eIF2 alpha Kinase HRI, Int. J. Mol. Sci., 2023;24(9):doi:10.3390/ijms24098064
Cabrero,EL;Robledo,RT;Cuñado,AC;Sardelli,DG;López,CH;Formatger,DG;Perez,LL et al, Risk factors of catheter- associated bloodstream infection: Systematic review and meta-analysis, PLoS One, 2023;18(3):doi:10.1371/journal.pone.0282290

Selected Projects

- FIS22046. Desarrollo de estrategias terapéuticas para disminuir la resistencia a tratamientos convencionales en cáncer de pulmón. Instituto de Salud Carlos III (ISCIII). Budget: 141.570€. 2023-2025. PI: Soto Cerrato, Vanessa.

- PID2020-120537RB-I00. Mecanismos de control de la apoptosis por prohibitina en células tumorales. Ministerio de Ciencia e Innovación. IP: Joan Gil Santano. (Universitat de Barcelona). 01/10/2021-31/9/2024. 181.500 €.

- PIFIISC19/24. Desarrollo y evaluación de una intervención sobre Atención Centrada en la Persona y Alfabetización Digital en Salud en Cáncer de Mama. Fundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC). IP: Yolanda Alvarez Perez. (Servicio de Evaluación del Servicio Canario de la Salud). Participació: Pepita Giménez Bonafé. 01/01/2020-31/12/2022. Import concedit: 17.419.61€.

- Grup consolidat de l’AGAUR “Apoptosi i cáncer”. IP: Joan Gil Santano

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