Epidemiology of bacterial infections. Research on pathogenesis and molecular basis of antimicrobial resistance

Summary

This group’s research covers various lines of clinical and microbiological research, and includes multiple-antibiotic-resistant bacterial infectious, which are a large cause of morbidity and mortality. The study of risk factors and clinical characteristics in hospital-acquired infections, as well as the knowledge of genotypes, virulence factors and mechanisms of antibiotic resistance of bacterial pathogens, are essential for controlling epidemic outbreaks due to multi-resistant bacteria.

758 Publications

Strategic lines

Clinical and molecular epidemiology of pneumococcal disease
Clinical and molecular epidemiology of bacteraemia/sepsis
Clinical and molecular epidemiology of methicillin-resistant S. aureus infections.
Dynamic of microbial populations in exacerbations of chronic obstructive pulmonary disease.
Molecular characterisation of invasive strains of S. pyogenes.
Antimicrobial resistance: phenotype characterisation and study of molecular bases.
New techniques in microbiological diagnosis.
Application of atomic force microscopy in the study of oral biofilm.

Selected Publications

Grillo,S;Pujol,M;Miró,JM;López Contreras,J;Euba,G;Gasch,O;Boix Palop,L et al, Cloxacillin plus fosfomycin versus cloxacillin alone for methicillin-susceptible Staphylococcus aureus bacteremia: a randomized trial, Nat. Med., 2023;29(10):2518-2525, doi:10.1038/s41591-023-02569-0
Laporte Amargos,J;Ulldemolins,M;Puig Asensio,M;Tebe,C;Castro,S;Carratala,J;Gudiol,C, Prolonged vs short-term infusion of beta-lactam antibiotics for the treatment of febrile neutropenia: A systematic review and meta-analysis, J. Infect., 2023;87(3):190-198, doi:10.1016/j.jinf.2023.06.023
Badia,JM;Arroyo Garcia,N;Vazquez,A;Almendral,A;Gomila Grange,A;Fraccalvieri,D;Pares,D et al, Leveraging a nationwide infection surveillance program to implement a colorectal surgical site infection reduction bundle: a pragmatic, prospective, and multicenter cohort study, Int. J. Surg., 2023;109(4):737-751, doi:10.1097/JS9.0000000000000277
Pérez Galera,S;Bravo Ferrer,JM;Paniagua,M;Kostyanev,T;de Kraker,M;Feifel,J;Sojo Dorado,J et al, Risk factors for infections caused by carbapenem-resistant Enterobacterales: an international matched case-control-control study (EURECA)., EClinicalMedicine, 2023;57101871-101871, doi:10.1016/j.eclinm.2023.101871
Troeman,DPR;Hazard,D;Timbermont,L;Malhotra Kumar,S;van Werkhoven,CH; Wolkewitz,M; Ruzin,A et al, Postoperative Staphylococcus aureus Infections in Patients With and Without Preoperative Colonization, JAMA Netw. Open, 2023;6(10):doi:10.1001/jamanetworkopen.2023.39793

Selected Projects

19FIS023. Impacto del genoma accesorio de Streptococcus pneumoniae en la resistencia y la patogenia de la enfermedad. Instituto de Salud Carlos III (ISCIII). Budget: 147.620€. 2019-2023. PI: ARDANUY TISAIRE, MARIA CARMEN.
FIS21052. Una perspectiva global de las enfermedades neumocócicas y la resistencia en tiempos de pandemia por COVID-19 y vacunación universal en pediatría. Instituto de Salud Carlos III (ISCIII). Budget: 91.960€. 2022-2024. PI: ARDANUY TISAIRE, MARIA CARMEN.
INT22008. Streptococcus pneumoniae and SARS-CoV-2. Revisiting the interactions between pneumococcus and viruses. MERCK SHARP & DOHME LLC. Budget: 67.536,84€. 2023-2025. PI: ARDANUY TISAIRE, MARIA CARMEN.
AGA23012. Programa Investigo de contractació de persones joves demandants d’ocupació en la realització d’iniciatives de recerca i innovació (INVESTIGO 2023). AGENCIA GESTIO D'AJUTS UNIV. I RECERCA. Budget: 66.217,84€. 2023-2025. PI: Puig Asensio, Mireia.
FIS23057. CONTRATO INTENSIFICACION ISCIII. Instituto de Salud Carlos III (ISCIII). Budget: 30.000€. 2023- . PI: Puig Asensio, Mireia.